GB1463520A
(en)
*
|
1974-09-06 |
1977-02-02 |
Pfizer Ltd |
Process for the production of imidazolines
|
JPS5373571A
(en)
*
|
1976-12-10 |
1978-06-30 |
Otsuka Pharmaceut Co Ltd |
Carbostyril derivatives
|
US4188393A
(en)
|
1977-04-22 |
1980-02-12 |
Sandoz Ltd. |
Treating spastic conditions or relaxing muscles
|
US4145421A
(en)
|
1977-04-22 |
1979-03-20 |
Sandoz Ltd. |
Treating spastic conditions
|
FR2449087A2
(fr)
*
|
1979-02-16 |
1980-09-12 |
Rhone Poulenc Ind |
Nouveaux derives de l'isoquinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent
|
US4486432A
(en)
*
|
1982-09-30 |
1984-12-04 |
Eli Lilly And Company |
Quinoxalinedione leukotriene release inhibitors
|
FR2541680B1
(fr)
*
|
1983-02-24 |
1985-06-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'amino-5 dithiole-1,2 one-3, leur preparation et les compositions medicinales qui les contiennent
|
JPS6118950U
(ja)
*
|
1984-07-10 |
1986-02-03 |
財団法人鉄道総合技術研究所 |
トロリ線の給油装置
|
JPS63296814A
(ja)
*
|
1987-05-29 |
1988-12-02 |
Ishigaki Kiko Kk |
集塵装置における濾材の目詰り除去装置
|
GB8827820D0
(en)
*
|
1988-11-29 |
1988-12-29 |
Janssen Pharmaceutica Nv |
(1h-azol-1-ylmethyl)substituted quinoline derivatives
|
US5281591A
(en)
*
|
1989-05-22 |
1994-01-25 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
US5180721A
(en)
*
|
1989-05-22 |
1993-01-19 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
US5204347A
(en)
*
|
1989-10-12 |
1993-04-20 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
|
US5077292A
(en)
*
|
1989-10-12 |
1991-12-31 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
|
US5112822A
(en)
*
|
1989-10-12 |
1992-05-12 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
|
US5326763A
(en)
*
|
1989-10-12 |
1994-07-05 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5198442A
(en)
*
|
1989-10-12 |
1993-03-30 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
|
US5231096A
(en)
*
|
1989-10-12 |
1993-07-27 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5021416A
(en)
*
|
1989-10-31 |
1991-06-04 |
Allergan, Inc. |
Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
|
US5215991A
(en)
*
|
1990-01-26 |
1993-06-01 |
Allergan, Inc. |
Combination of selective alpha-adrenergic agonists and Na+ /H+ ex
|
US5130441A
(en)
*
|
1990-02-06 |
1992-07-14 |
Allergan, Inc. |
Method for producing amino-2-imidazoline derivatives
|
US5237072A
(en)
*
|
1990-02-06 |
1993-08-17 |
Allergan, Inc. |
Method for producing amino-2-imidazoline derivatives
|
US5252595A
(en)
*
|
1990-02-28 |
1993-10-12 |
Allergan, Inc. |
Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
|
US5091528A
(en)
*
|
1990-09-12 |
1992-02-25 |
Allergan, Inc. |
6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
|
US6323204B1
(en)
*
|
1993-10-13 |
2001-11-27 |
Allergan |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
EP1285657A3
(en)
*
|
1993-10-13 |
2003-08-20 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5580892A
(en)
*
|
1993-10-22 |
1996-12-03 |
Allergan |
Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
|
US5478858A
(en)
*
|
1993-12-17 |
1995-12-26 |
The Procter & Gamble Company |
5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
|
ATE194771T1
(de)
*
|
1993-12-17 |
2000-08-15 |
Procter & Gamble |
6-(2-imidazolinylamino) chinoxalin-verbindungen als alpha-2-adrenorezeptoragonisten
|
US5578607A
(en)
*
|
1993-12-17 |
1996-11-26 |
The Procter & Gamble Company |
6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
NZ333370A
(en)
*
|
1993-12-17 |
2001-03-30 |
Procter & Gamble |
6-(2-Imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
US5576437A
(en)
*
|
1993-12-17 |
1996-11-19 |
The Procter & Gamble Company |
7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
|
AU677513B2
(en)
*
|
1994-02-08 |
1997-04-24 |
Alcon Laboratories, Inc. |
Novel process for preparation of clonidine derivatives
|
EP0775134A4
(en)
*
|
1994-08-04 |
1997-08-13 |
Synaptic Pharma Corp |
NEW BENZIMIDAZOLE DERIVATIVES
|
US6294563B1
(en)
|
1994-10-27 |
2001-09-25 |
Allergan Sales, Inc. |
Combinations of prostaglandins and brimonidine or derivatives thereof
|
US6194415B1
(en)
|
1995-06-28 |
2001-02-27 |
Allergan Sales, Inc. |
Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
|
US5916900A
(en)
*
|
1995-06-29 |
1999-06-29 |
The Procter & Gamble Company |
7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
TR199901885T2
(xx)
*
|
1996-11-25 |
1999-10-21 |
The Procter & Gamble Company |
Alfa-2 adrenosept�r agonistleri olarak yararl� 2-imidazolinilaminoindol bile�ikleri.
|
US6172095B1
(en)
|
1996-11-25 |
2001-01-09 |
The Procter & Gamble Company |
Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
|
AU736992B2
(en)
*
|
1996-11-25 |
2001-08-09 |
Procter & Gamble Company, The |
2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
|
AU5433898A
(en)
*
|
1996-11-25 |
1998-06-22 |
Procter & Gamble Company, The |
2-imidazolinylaminobenzothiazole compounds useful as alpha-2 adrenoceptor agonists
|
US6306877B1
(en)
|
1999-08-09 |
2001-10-23 |
The Procter & Gamble Co. |
Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
|
JP2001506600A
(ja)
|
1996-11-25 |
2001-05-22 |
ザ プロクター アンド ギャンブル カンパニー |
α―2アドレナリン受容体作動薬として有用なグアニジニル複素環式化合物
|
US6495583B1
(en)
|
1997-03-25 |
2002-12-17 |
Synaptic Pharmaceutical Corporation |
Benzimidazole derivatives
|
KR20010032435A
(ko)
|
1997-11-24 |
2001-04-25 |
데이비드 엠 모이어 |
5-(2-이미다졸리닐아미노)벤즈이미다졸 유도체, 그의 제조및 대사 안정성이 개선된 알파-아드레날린수용체아고니스트로서의 그의 용도
|
WO2004073708A1
(en)
|
1998-12-17 |
2004-09-02 |
Dean Thomas R |
Brinzolamide and brimonidine for treating ocular conditions
|
US8858961B2
(en)
|
2000-07-14 |
2014-10-14 |
Allergan, Inc. |
Compositions containing alpha-2-adrenergic agonist components
|
JP2004503593A
(ja)
|
2000-07-14 |
2004-02-05 |
アラーガン、インコーポレイテッド |
増大した溶解度を持つ治療活性成分を含む組成物
|
US20050026924A1
(en)
*
|
2000-07-14 |
2005-02-03 |
Allergan, Inc. |
Compositions containing alpha-2-adrenergic agonist components
|
IL151530A0
(en)
|
2000-07-14 |
2003-04-10 |
Allergan Sales Inc |
Compositions containing alpha-2-adrenergic agonist components
|
US20040214829A1
(en)
*
|
2000-07-14 |
2004-10-28 |
Allergan, Inc. |
Compositions containing alpha-2-adrenergic agonist components
|
DE10161767A1
(de)
*
|
2001-12-15 |
2003-06-26 |
Merck Patent Gmbh |
2-Guanidino-4-heterocyclyl-chinazoline
|
US7030149B2
(en)
|
2002-04-19 |
2006-04-18 |
Allergan, Inc. |
Combination of brimonidine timolol for topical ophthalmic use
|
US7642258B2
(en)
*
|
2002-04-19 |
2010-01-05 |
Allergan, Inc. |
Combination of brimonidine and timolol for topical ophthalmic use
|
PL216373B1
(pl)
*
|
2002-10-08 |
2014-03-31 |
Allergan Inc |
Zastosowanie selektywnego agonisty receptora α 2B adrenergicznego lub α 2B/2C adrenergicznego
|
KR20050056235A
(ko)
*
|
2002-10-08 |
2005-06-14 |
알러간, 인코포레이티드 |
(2-이미다졸린-2-일아미노)퀴녹살린을 사용하여 치매 및파킨슨병을 처치하는 방법
|
US20040191332A1
(en)
*
|
2003-03-27 |
2004-09-30 |
Allergan, Inc. |
Preserved ophthalmic compositions
|
US8410102B2
(en)
|
2003-05-27 |
2013-04-02 |
Galderma Laboratories Inc. |
Methods and compositions for treating or preventing erythema
|
US7439241B2
(en)
|
2003-05-27 |
2008-10-21 |
Galderma Laboratories, Inc. |
Compounds, formulations, and methods for treating or preventing rosacea
|
WO2005014046A2
(en)
*
|
2003-08-07 |
2005-02-17 |
Allergan, Inc. |
Compositions for delivery of therapeutics into the eyes and methods for making and using the same
|
US7501427B2
(en)
|
2003-08-14 |
2009-03-10 |
Array Biopharma, Inc. |
Quinazoline analogs as receptor tyrosine kinase inhibitors
|
ES2399427T3
(es)
*
|
2003-08-14 |
2013-04-01 |
Array Biopharma, Inc. |
Análogos de quinazolina como inhibidores de los receptores de la tirosina-quinasa
|
WO2005039567A1
(en)
*
|
2003-10-08 |
2005-05-06 |
Allergan, Inc. |
Pharmaceutical compositions comprising alpha-2-adrenergics and trefoil factor family peptides
|
PL1761266T3
(pl)
|
2004-05-25 |
2013-09-30 |
Galderma Pharma Sa |
Związki, preparaty i sposoby leczenia lub zapobiegania procesom zapalnym skóry
|
US7534795B2
(en)
*
|
2005-10-25 |
2009-05-19 |
Allergan, Inc. |
Compounds and their use related to compositions for treating disease
|
CN101355876B
(zh)
|
2005-11-09 |
2012-09-05 |
康宾纳特克斯公司 |
一种适用于眼部给药的组合物
|
CN102887891B
(zh)
|
2005-11-15 |
2016-03-09 |
阿雷生物药品公司 |
N4-苯基-喹唑啉-4-胺衍生物和相关化合物
|
WO2008074068A1
(en)
*
|
2006-12-20 |
2008-06-26 |
Prana Biotechnology Limited |
Substituted quinoline derivatives as antiamyloidogeneic agents
|
WO2008144399A1
(en)
*
|
2007-05-18 |
2008-11-27 |
Bausch & Lomb Incorporated |
COMPLEXES COMPRISING α2-ADRENERGIC RECEPTOR AGONISTS AND COMPOSITIONS
|
US7842714B2
(en)
|
2008-03-03 |
2010-11-30 |
Allergan, Inc. |
Ketorolac tromethamine compositions for treating ocular pain
|
US9192571B2
(en)
*
|
2008-03-03 |
2015-11-24 |
Allergan, Inc. |
Ketorolac tromethamine compositions for treating or preventing ocular pain
|
AU2010303545B2
(en)
|
2009-10-06 |
2016-05-12 |
Allergan, Inc. |
2H-pyrrol-5-amine derivatives as alpha adrenergic receptor modulators
|
EP2329849B1
(en)
|
2009-11-18 |
2015-04-29 |
Galderma Research & Development |
Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder
|
US8394800B2
(en)
|
2009-11-19 |
2013-03-12 |
Galderma Laboratories, L.P. |
Method for treating psoriasis
|
US9522153B2
(en)
|
2009-12-22 |
2016-12-20 |
Allergan, Inc. |
Compositions and methods for lowering intraocular pressure
|
DK2552449T3
(en)
|
2010-03-26 |
2017-06-19 |
Galderma Res & Dev |
COMPOSITIONS INCLUDING BRIMONIDINE FOR TREATMENT OF ERYTHEM
|
KR20150058551A
(ko)
|
2010-03-26 |
2015-05-28 |
갈데르마 리써어치 앤드 디벨로프먼트 |
모세혈관 확장증의 안전하고 유효한 치료를 위한 개선된 방법 및 조성물
|
EP2555750A2
(en)
|
2010-04-07 |
2013-02-13 |
Allergan, Inc. |
Combinations of preservative compositions for ophthalmic formulations
|
JP2013523828A
(ja)
|
2010-04-07 |
2013-06-17 |
アラーガン インコーポレイテッド |
眼科用組成物のための保存剤の組み合わせ
|
DK2598119T3
(en)
|
2010-07-29 |
2019-01-07 |
Allergan Inc |
CONSERVATIVE-FREE BRIMONIDINE AND TIMOLOL SOLUTIONS
|
CA2814952C
(en)
|
2010-10-21 |
2016-05-10 |
Galderma S.A. |
Brimonidine gel compositions and methods of use
|
US8053427B1
(en)
|
2010-10-21 |
2011-11-08 |
Galderma R&D SNC |
Brimonidine gel composition
|
US8815861B2
(en)
*
|
2011-07-25 |
2014-08-26 |
Allergan, Inc. |
N-(imidazolidin-2-ylidene)quinoline derivatives as modulators of alpha 2 adrenergic receptors
|
GR1009419B
(el)
|
2017-11-07 |
2018-12-14 |
Φαρματεν Αβεε |
Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου
|