FR2162562A1 - Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydride - Google Patents

Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydride

Info

Publication number
FR2162562A1
FR2162562A1 FR7243651A FR7243651A FR2162562A1 FR 2162562 A1 FR2162562 A1 FR 2162562A1 FR 7243651 A FR7243651 A FR 7243651A FR 7243651 A FR7243651 A FR 7243651A FR 2162562 A1 FR2162562 A1 FR 2162562A1
Authority
FR
France
Prior art keywords
reaction
prepn
pyrrolidinylmethylamine
pyrrolidinylmethyl
benzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7243651A
Other languages
French (fr)
Other versions
FR2162562B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COFIMED ETS
Original Assignee
COFIMED ETS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COFIMED ETS filed Critical COFIMED ETS
Publication of FR2162562A1 publication Critical patent/FR2162562A1/en
Application granted granted Critical
Publication of FR2162562B1 publication Critical patent/FR2162562B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for the prepn. of the compounds of formula (I) by the reaction: (I) is known to have antipsychotic properties and also to be useful in the treatment of gastroduodenal ulcers, vertigo, and migraine of digestive origin. The process gives better yields of purer product than the known process described in FR. 1,472,025. The product is sufficiently pure to be used for pharmaceutical purposes after one recrystallisation. Temp. is pref. below 5 degrees C and suitable solvents are benzene and acetone. (II) is prepd by treatment of 2-methoxy-5-sulphamoylbenzoic acid (IV) with ethyl chloroformate (V) in the presence of an HCl acceptor, and is used for the reaction with (III) without purification, other than the elimination of the hydrochloride salt of the base used as acid acceptor.
FR7243651A 1971-12-09 1972-12-07 Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydride Granted FR2162562A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3218171 1971-12-09

Publications (2)

Publication Number Publication Date
FR2162562A1 true FR2162562A1 (en) 1973-07-20
FR2162562B1 FR2162562B1 (en) 1976-07-02

Family

ID=11234973

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7243651A Granted FR2162562A1 (en) 1971-12-09 1972-12-07 Pyrrolidinylmethyl benzamide prepn - by reaction of a pyrrolidinylmethylamine with a benzoic acid mixed anhydride

Country Status (3)

Country Link
JP (1) JPS4864066A (en)
ES (1) ES408918A1 (en)
FR (1) FR2162562A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1472025A (en) * 1964-01-13 1967-03-10 Merck & Co Inc Manufacturing process of new heterocyclic benzamides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1472025A (en) * 1964-01-13 1967-03-10 Merck & Co Inc Manufacturing process of new heterocyclic benzamides

Also Published As

Publication number Publication date
FR2162562B1 (en) 1976-07-02
ES408918A1 (en) 1975-10-16
JPS4864066A (en) 1973-09-05

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Legal Events

Date Code Title Description
ST Notification of lapse