FR2160716A1 - Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin - Google Patents
Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycinInfo
- Publication number
- FR2160716A1 FR2160716A1 FR7141849A FR7141849A FR2160716A1 FR 2160716 A1 FR2160716 A1 FR 2160716A1 FR 7141849 A FR7141849 A FR 7141849A FR 7141849 A FR7141849 A FR 7141849A FR 2160716 A1 FR2160716 A1 FR 2160716A1
- Authority
- FR
- France
- Prior art keywords
- duborimycin
- adriamycin
- daunorubicin
- antibiotics
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HJEZFVLKJYFNQW-PRFXOSGESA-N (13S)-13-dihydrodaunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)[C@H](C)O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 HJEZFVLKJYFNQW-PRFXOSGESA-N 0.000 title abstract 4
- HJEZFVLKJYFNQW-UHFFFAOYSA-N Daunorubicinol Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)O)CC1OC1CC(N)C(O)C(C)O1 HJEZFVLKJYFNQW-UHFFFAOYSA-N 0.000 title abstract 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title abstract 4
- 229950000950 daunorubicinol Drugs 0.000 title abstract 4
- 239000003242 anti bacterial agent Substances 0.000 title abstract 3
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 title abstract 2
- 229940009456 adriamycin Drugs 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title abstract 2
- 229960000975 daunorubicin Drugs 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 3
- 230000000259 anti-tumor effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 241000699670 Mus sp. Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000006268 Sarcoma 180 Diseases 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- NKZRZOVSJNSBFR-FEMMEMONSA-N doxorubicinol Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)[C@@H](O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 NKZRZOVSJNSBFR-FEMMEMONSA-N 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7141849A FR2160716A1 (en) | 1971-11-23 | 1971-11-23 | Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin |
| IE74/72A IE35993B1 (en) | 1971-01-20 | 1972-01-19 | Process for the preparation of antibiotics 20,798 rp and 27,706 rp and the antibiotic 27,706 rp |
| AU38090/72A AU453869B2 (en) | 1971-01-20 | 1972-01-19 | Process forthe preparation of antibiotics 20, 798 rp and 27, 706 rp andthe antibiotic 27, 706 rp |
| US05/219,065 US3970641A (en) | 1971-01-20 | 1972-01-19 | Antibiotic 27,706 RP and salt thereof |
| JP47007005A JPS5233639B1 (https=) | 1971-01-20 | 1972-01-19 | |
| DK27472AA DK128114B (da) | 1971-01-20 | 1972-01-19 | Fremgangsmåde til fremstilling af et antibiotikum. |
| SE7200606A SE400975B (sv) | 1971-01-20 | 1972-01-19 | Forfarande for framstellning av ett nytt antibiotikum, benemnt 27 706 rp |
| GB258172A GB1322872A (en) | 1971-01-20 | 1972-01-19 | Process for the preparation of antibiotics |
| ES399063A ES399063A1 (es) | 1971-01-20 | 1972-01-20 | Procedimiento para la obtencion de antibioticos con propie-dades antitumorales. |
| DE2202690A DE2202690C3 (de) | 1971-01-20 | 1972-01-20 | Antibiotikum 27 706 RP, Verfahren zu dessen Herstellung und Arzneimittel |
| AT47672A AT311553B (de) | 1971-01-20 | 1972-01-20 | Verfahren zur Herstellung von Antibiotika |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7141849A FR2160716A1 (en) | 1971-11-23 | 1971-11-23 | Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2160716A1 true FR2160716A1 (en) | 1973-07-06 |
| FR2160716B1 FR2160716B1 (https=) | 1975-02-07 |
Family
ID=9086188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7141849A Granted FR2160716A1 (en) | 1971-01-20 | 1971-11-23 | Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2160716A1 (https=) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE713773A (fr) * | 1967-04-18 | 1968-10-17 | Farmaceutici Italia | Substance antibiotique, ses derives et leur procede de preparation |
| BE731398A (fr) * | 1968-04-12 | 1969-10-13 | Procédé de préparation de l'adriamycine et de l'adriamycinone |
-
1971
- 1971-11-23 FR FR7141849A patent/FR2160716A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE713773A (fr) * | 1967-04-18 | 1968-10-17 | Farmaceutici Italia | Substance antibiotique, ses derives et leur procede de preparation |
| BE731398A (fr) * | 1968-04-12 | 1969-10-13 | Procédé de préparation de l'adriamycine et de l'adriamycinone |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2160716B1 (https=) | 1975-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |