CA1016165A - 3'-deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof - Google Patents

3'-deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof

Info

Publication number
CA1016165A
CA1016165A CA187,726A CA187726A CA1016165A CA 1016165 A CA1016165 A CA 1016165A CA 187726 A CA187726 A CA 187726A CA 1016165 A CA1016165 A CA 1016165A
Authority
CA
Canada
Prior art keywords
neamine
production
deoxy derivatives
aminoglycosidic antibiotics
aminoglycosidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA187,726A
Other versions
CA187726S (en
Inventor
Osamu Tsuchiya
Sumio Umezawa
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of CA1016165A publication Critical patent/CA1016165A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA187,726A 1972-12-08 1973-12-07 3'-deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof Expired CA1016165A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12243672A JPS57876B2 (en) 1972-12-08 1972-12-08

Publications (1)

Publication Number Publication Date
CA1016165A true CA1016165A (en) 1977-08-23

Family

ID=14835788

Family Applications (1)

Application Number Title Priority Date Filing Date
CA187,726A Expired CA1016165A (en) 1972-12-08 1973-12-07 3'-deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof

Country Status (10)

Country Link
JP (1) JPS57876B2 (en)
AR (1) AR201932A1 (en)
AT (1) AT332543B (en)
BE (1) BE808393A (en)
CA (1) CA1016165A (en)
DE (2) DE2366288C3 (en)
ES (1) ES421251A1 (en)
FR (1) FR2209745B1 (en)
GB (1) GB1426910A (en)
NL (1) NL164040C (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116642A (en) * 1974-08-01 1976-02-10 Meiji Seika Co 3** deokishineamin oyobi sonokanrenkoseibutsushitsuno seizoho
FR2290908A1 (en) * 1974-11-13 1976-06-11 Roussel Uclaf NEW AMINOGLYCOSIDIC DERIVATIVE AND ITS SALTS, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2358156A1 (en) * 1976-03-31 1978-02-10 Roussel Uclaf Antibacterial 2-desoxy-streptamine derivs. - prepd. from methyl-4,6-benzylidene-3-ethoxy:carbonylamino 3-desoxy-gluco:pyranoside
JPS5663993A (en) * 1979-10-30 1981-05-30 Microbial Chem Res Found Novel preparation of tobramycin
JPS6140297A (en) * 1984-08-02 1986-02-26 Microbial Chem Res Found 3'-fluoro-3'-deoxykanamycin a
US4661474A (en) * 1984-12-15 1987-04-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 2',3'-dideoxy-2'-fluorokanamycin A and 1-N-(α-hydroxy-ω-aminoalkanoyl) derivatives thereof
JPH0544930Y2 (en) * 1986-01-24 1993-11-16
JPH01157976A (en) * 1987-12-16 1989-06-21 Towa Kasei Kogyo Kk (4s, 5s)-4,5-cyclohexylidenedioxy-2-cyclopenten-1-one, enantiomer and synthetic intermediate thereof and production thereof

Also Published As

Publication number Publication date
JPS57876B2 (en) 1982-01-08
AR201932A1 (en) 1975-04-30
NL164040B (en) 1980-06-16
ES421251A1 (en) 1976-04-01
DE2366288B2 (en) 1981-07-02
DE2366288C3 (en) 1982-03-18
DE2361159A1 (en) 1974-06-20
ATA1031873A (en) 1976-01-15
DE2361159C3 (en) 1982-04-29
GB1426910A (en) 1976-03-03
BE808393A (en) 1974-03-29
NL164040C (en) 1980-11-17
AT332543B (en) 1976-10-11
FR2209745A1 (en) 1974-07-05
JPS4980038A (en) 1974-08-02
NL7316777A (en) 1974-06-11
FR2209745B1 (en) 1977-09-23
DE2361159B2 (en) 1981-07-02

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