FR2152441A1 - N-piperazinobarbituric acids - with analgesic and hypotensive activity - Google Patents
N-piperazinobarbituric acids - with analgesic and hypotensive activityInfo
- Publication number
- FR2152441A1 FR2152441A1 FR7133237A FR7133237A FR2152441A1 FR 2152441 A1 FR2152441 A1 FR 2152441A1 FR 7133237 A FR7133237 A FR 7133237A FR 7133237 A FR7133237 A FR 7133237A FR 2152441 A1 FR2152441 A1 FR 2152441A1
- Authority
- FR
- France
- Prior art keywords
- analgesic
- cpds
- piperazinobarbituric
- acids
- hypotensive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Abstract
Cpds. of formula (I): (where R1 = H, Et; R2 = H, Me or phenyl; R3 = pyrrolidino, morpholino, isopropylamin, dimethylamino, cyclohexyloxy; n = 0 or 1) are prepd. from semicarbazides of formula: (where R3 and n are as in I). The cpds. I are hypotensive and analgesic agents, the analgesic dose in mice being about 100 mg/kg orally and the hypotensive dose 0.5-2 mg/kg i.v. in rats. Cpds. (II) are intermediates prepared by reaction of the corresponding 1-amino-piperazines with KCNO. II are converted into I by reaction with the appropriate beta-dicarboxylic esters in presence of sodium ethoxide or sodium hydride.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7133237A FR2152441A1 (en) | 1971-09-15 | 1971-09-15 | N-piperazinobarbituric acids - with analgesic and hypotensive activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7133237A FR2152441A1 (en) | 1971-09-15 | 1971-09-15 | N-piperazinobarbituric acids - with analgesic and hypotensive activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2152441A1 true FR2152441A1 (en) | 1973-04-27 |
FR2152441B1 FR2152441B1 (en) | 1975-08-01 |
Family
ID=9082975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7133237A Granted FR2152441A1 (en) | 1971-09-15 | 1971-09-15 | N-piperazinobarbituric acids - with analgesic and hypotensive activity |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2152441A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002051836A1 (en) * | 2000-12-27 | 2002-07-04 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
-
1971
- 1971-09-15 FR FR7133237A patent/FR2152441A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002051836A1 (en) * | 2000-12-27 | 2002-07-04 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
Also Published As
Publication number | Publication date |
---|---|
FR2152441B1 (en) | 1975-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |