ES398222A1 - Benzodiazepine derivatives and a process for the manjfacture thereof - Google Patents
Benzodiazepine derivatives and a process for the manjfacture thereofInfo
- Publication number
- ES398222A1 ES398222A1 ES398222A ES398222A ES398222A1 ES 398222 A1 ES398222 A1 ES 398222A1 ES 398222 A ES398222 A ES 398222A ES 398222 A ES398222 A ES 398222A ES 398222 A1 ES398222 A1 ES 398222A1
- Authority
- ES
- Spain
- Prior art keywords
- same meaning
- general formula
- compound
- formula
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of henzodiazepine derivatives of the general formula ** (See formula) ** in which R, R1 and R2 represent hydrogen or lower alkyl and R3 represents hydrogen or halogen whose process comprises a) hydrolyze a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before and R4 and R5 represent a fraction capable of being removed by hydrolyzation, or b) reacting a benzophenone of the general formula ** (See formula) ** in which R, R1 and R3 have the same meaning as before, with an alpha-amino acid of the general formula ** (See formula) ** in which R2 has the same meaning as before, or a respective ester, or c) removing N-oxide from a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before, with a reducing agent, or d) dehydrating a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before, or e) converting a compound of the general formula in which R, R1, R2 and R3 have the same meaning as before, and X represents arylsulfonyl, arylsulfonyloxy, alkylsulfonyl, alkylsulfonyloxy, lower alkanoyl or lower alkanoyloxy, in the corresponding 4,5-dehydro derivative, and f) isomerizing a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before, by basic treatment, or g) for the preparation of compounds of the formula I, wherein R2 is hydrogen, hydrolyze a compound of the general formula ** (See formula) ** in which R, R1 and R3 have the same meaning as before and R6 represents lower alkyl, under acidic conditions, h) reducing a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before, to effect conversion into the corresponding 4,5-dehydro derivative, or i) dehydrogenating or oxidizing a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before, in position 4,5, or j) oxidizing a compound of the general formula ** (See formula) ** in which R, R1, R2 and R3 have the same meaning as before and B represents carbonyl or methylene, or a respective 4,5-dihydro derivative. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10118370A | 1970-12-23 | 1970-12-23 | |
| US10111770A | 1970-12-23 | 1970-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES398222A1 true ES398222A1 (en) | 1975-06-01 |
Family
ID=26797912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398222A Expired ES398222A1 (en) | 1970-12-23 | 1971-12-22 | Benzodiazepine derivatives and a process for the manjfacture thereof |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5610310B1 (en) |
| AR (1) | AR193632A1 (en) |
| AT (2) | AT322556B (en) |
| AU (1) | AU458983B2 (en) |
| BE (2) | BE777098A (en) |
| BG (1) | BG17804A3 (en) |
| BR (1) | BR7108411D0 (en) |
| CA (2) | CA935157A (en) |
| CH (2) | CH582162A5 (en) |
| DD (1) | DD95384A5 (en) |
| DE (2) | DE2163642A1 (en) |
| ES (1) | ES398222A1 (en) |
| FR (2) | FR2154391B1 (en) |
| GB (1) | GB1321938A (en) |
| HU (1) | HU164249B (en) |
| IL (1) | IL38234A0 (en) |
| LU (1) | LU64491A1 (en) |
| NL (3) | NL7117480A (en) |
| PL (1) | PL83080B1 (en) |
| RO (1) | RO70586A (en) |
| YU (1) | YU35004B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100932093B1 (en) | 2006-09-27 | 2009-12-16 | 주식회사종근당 | Benzophenone Derivatives Useful as Inhibitors of Microtubule Formation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4833759A (en) * | 1971-09-01 | 1973-05-12 |
-
1971
- 1971-11-26 IL IL38234A patent/IL38234A0/en unknown
- 1971-11-30 CH CH1740171A patent/CH582162A5/xx not_active IP Right Cessation
- 1971-12-03 CH CH1761371A patent/CH565775A5/xx not_active IP Right Cessation
- 1971-12-03 CA CA129226A patent/CA935157A/en not_active Expired
- 1971-12-20 BR BR8411/71A patent/BR7108411D0/en unknown
- 1971-12-20 NL NL7117480A patent/NL7117480A/xx not_active Application Discontinuation
- 1971-12-21 DE DE19712163642 patent/DE2163642A1/en active Pending
- 1971-12-21 AU AU37153/71A patent/AU458983B2/en not_active Expired
- 1971-12-21 DE DE19712163522 patent/DE2163522A1/en active Pending
- 1971-12-21 LU LU64491A patent/LU64491A1/xx unknown
- 1971-12-21 JP JP10401571A patent/JPS5610310B1/ja active Pending
- 1971-12-21 RO RO7169138A patent/RO70586A/en unknown
- 1971-12-21 CA CA130,660A patent/CA948629A/en not_active Expired
- 1971-12-22 BE BE777098A patent/BE777098A/en unknown
- 1971-12-22 AR AR239761A patent/AR193632A1/en active
- 1971-12-22 ES ES398222A patent/ES398222A1/en not_active Expired
- 1971-12-22 AT AT1105071A patent/AT322556B/en not_active IP Right Cessation
- 1971-12-22 AT AT847174*1A patent/AT325628B/en not_active IP Right Cessation
- 1971-12-22 DD DD159822A patent/DD95384A5/xx unknown
- 1971-12-22 BE BE777097A patent/BE777097A/en unknown
- 1971-12-23 FR FR7146456A patent/FR2154391B1/fr not_active Expired
- 1971-12-23 YU YU3235/71A patent/YU35004B/en unknown
- 1971-12-23 GB GB5998071A patent/GB1321938A/en not_active Expired
- 1971-12-23 BG BG019309A patent/BG17804A3/en unknown
- 1971-12-23 HU HUHO1442A patent/HU164249B/hu unknown
- 1971-12-23 FR FR7146455A patent/FR2119070A1/en not_active Withdrawn
- 1971-12-23 NL NL7117762A patent/NL7117762A/xx unknown
- 1971-12-23 NL NL7117760A patent/NL7117760A/xx unknown
- 1971-12-23 PL PL1971152445A patent/PL83080B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2119070A1 (en) | 1972-08-04 |
| YU323571A (en) | 1979-12-31 |
| FR2154391A1 (en) | 1973-05-11 |
| JPS5610310B1 (en) | 1981-03-06 |
| FR2154391B1 (en) | 1975-03-14 |
| IL38234A0 (en) | 1972-01-27 |
| YU35004B (en) | 1980-06-30 |
| PL83080B1 (en) | 1975-12-31 |
| CH582162A5 (en) | 1976-11-30 |
| GB1321938A (en) | 1973-07-04 |
| NL7117762A (en) | 1972-06-27 |
| DD95384A5 (en) | 1973-02-05 |
| BE777098A (en) | 1972-06-22 |
| AT325628B (en) | 1975-10-27 |
| DE2163522A1 (en) | 1972-07-13 |
| CA948629A (en) | 1974-06-04 |
| AR193632A1 (en) | 1973-05-11 |
| AU3715371A (en) | 1973-06-28 |
| BE777097A (en) | 1972-06-22 |
| RO70586A (en) | 1981-07-30 |
| LU64491A1 (en) | 1973-07-16 |
| NL7117480A (en) | 1972-06-27 |
| AU458983B2 (en) | 1975-03-13 |
| HU164249B (en) | 1974-01-28 |
| CA935157A (en) | 1973-10-09 |
| BR7108411D0 (en) | 1973-06-14 |
| BG17804A3 (en) | 1973-12-25 |
| DE2163642A1 (en) | 1972-07-13 |
| NL7117760A (en) | 1972-06-27 |
| AT322556B (en) | 1975-05-26 |
| CH565775A5 (en) | 1975-08-29 |
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