FR2151043A1 - 3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum - Google Patents
3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serumInfo
- Publication number
- FR2151043A1 FR2151043A1 FR7230950A FR7230950A FR2151043A1 FR 2151043 A1 FR2151043 A1 FR 2151043A1 FR 7230950 A FR7230950 A FR 7230950A FR 7230950 A FR7230950 A FR 7230950A FR 2151043 A1 FR2151043 A1 FR 2151043A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- alkyl
- isoquinoline
- cholesterol
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 2
- YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical class C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 title 1
- 235000012000 cholesterol Nutrition 0.000 title 1
- 210000002966 serum Anatomy 0.000 title 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002841 Lewis acid Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000005704 oxymethylene group Chemical group [H]C([H])([*:2])O[*:1] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C49/215—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2143744A DE2143744A1 (de) | 1971-09-01 | 1971-09-01 | 3,4-dihydro-2h-isochinolin-1-one und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2151043A1 true FR2151043A1 (en) | 1973-04-13 |
Family
ID=5818353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7230950A Withdrawn FR2151043A1 (en) | 1971-09-01 | 1972-08-31 | 3,4-dihydro-2h-isoquinoline-1-ones - useful for lowering of cholesterol - and triglyceride level in serum |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS4834886A (en:Method) |
| AU (1) | AU4610372A (en:Method) |
| BE (1) | BE788322A (en:Method) |
| BG (3) | BG19375A3 (en:Method) |
| CA (1) | CA983039A (en:Method) |
| DD (1) | DD102147A5 (en:Method) |
| DE (1) | DE2143744A1 (en:Method) |
| FR (1) | FR2151043A1 (en:Method) |
| HU (1) | HU165204B (en:Method) |
| IL (1) | IL40249A0 (en:Method) |
| NL (1) | NL7211626A (en:Method) |
| ZA (1) | ZA725996B (en:Method) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2385720A1 (fr) * | 1977-03-29 | 1978-10-27 | Parcor | Thieno(2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application en therapeutique |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5650682B2 (en:Method) * | 1974-03-25 | 1981-12-01 | ||
| DE2438966A1 (de) * | 1974-08-14 | 1976-03-04 | Hoechst Ag | Basisch substituierte 3,,4-dihydro2h-isochinolin-1-one und verfahren zu ihrer herstellung |
| DE3443994A1 (de) * | 1984-06-14 | 1985-12-19 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von gegebenenfalls substituierten benz(c,d)-indol-2-onen |
| US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CN110452216B (zh) | 2014-04-02 | 2022-08-26 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
-
1971
- 1971-09-01 DE DE2143744A patent/DE2143744A1/de active Pending
-
1972
- 1972-08-09 CA CA148,981A patent/CA983039A/en not_active Expired
- 1972-08-16 DD DD165086A patent/DD102147A5/xx unknown
- 1972-08-25 NL NL7211626A patent/NL7211626A/xx unknown
- 1972-08-28 BG BG023338A patent/BG19375A3/xx unknown
- 1972-08-28 BG BG021265A patent/BG20410A3/xx unknown
- 1972-08-28 BG BG023337A patent/BG19799A3/xx unknown
- 1972-08-29 IL IL40249A patent/IL40249A0/xx unknown
- 1972-08-30 AU AU46103/72A patent/AU4610372A/en not_active Expired
- 1972-08-31 FR FR7230950A patent/FR2151043A1/fr not_active Withdrawn
- 1972-08-31 ZA ZA725996A patent/ZA725996B/xx unknown
- 1972-09-01 JP JP47087840A patent/JPS4834886A/ja active Pending
- 1972-09-01 HU HUHO1512A patent/HU165204B/hu unknown
- 1972-09-01 BE BE788322D patent/BE788322A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2385720A1 (fr) * | 1977-03-29 | 1978-10-27 | Parcor | Thieno(2,3-c) et (3,2-c) pyridines, leur procede de preparation et leur application en therapeutique |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2143744A1 (de) | 1973-03-08 |
| BE788322A (fr) | 1973-03-01 |
| ZA725996B (en) | 1973-06-27 |
| AU4610372A (en) | 1974-03-07 |
| NL7211626A (en:Method) | 1973-03-05 |
| IL40249A0 (en) | 1972-10-29 |
| CA983039A (en) | 1976-02-03 |
| JPS4834886A (en:Method) | 1973-05-22 |
| BG19375A3 (bg) | 1975-06-15 |
| BG20410A3 (bg) | 1975-11-05 |
| HU165204B (en:Method) | 1974-07-27 |
| DD102147A5 (en:Method) | 1973-12-05 |
| BG19799A3 (bg) | 1975-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |