FR2133503A1 - 2-(1-phenylpyrazol-4-yl)propionic acids - with antiinflammatory analgesic and antirheumatic activity - Google Patents
2-(1-phenylpyrazol-4-yl)propionic acids - with antiinflammatory analgesic and antirheumatic activityInfo
- Publication number
- FR2133503A1 FR2133503A1 FR7113296A FR7113296A FR2133503A1 FR 2133503 A1 FR2133503 A1 FR 2133503A1 FR 7113296 A FR7113296 A FR 7113296A FR 7113296 A FR7113296 A FR 7113296A FR 2133503 A1 FR2133503 A1 FR 2133503A1
- Authority
- FR
- France
- Prior art keywords
- phenylpyrazol
- propionic acids
- antiinflammatory
- cpds
- antiinflammatory analgesic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cpds. are of formula (I): (where X is H, halogen, alkyl, OH, alkoxy; R is H or phenyl opt. substd. by X), and salts of (I), with organic and inorganic bases. The cpds. have antiinflammatory and analgesic activity and may be used for treatment of rheumatic diseases at 100-1000 mg/day in man. They are prepd. by alpha-methylation of esters of the corresp. acetic acids using methyl iodide in presence of sodamide and hydrolysing the resulting propionic acid ester.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7113296A FR2133503A1 (en) | 1971-04-15 | 1971-04-15 | 2-(1-phenylpyrazol-4-yl)propionic acids - with antiinflammatory analgesic and antirheumatic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7113296A FR2133503A1 (en) | 1971-04-15 | 1971-04-15 | 2-(1-phenylpyrazol-4-yl)propionic acids - with antiinflammatory analgesic and antirheumatic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2133503A1 true FR2133503A1 (en) | 1972-12-01 |
FR2133503B1 FR2133503B1 (en) | 1974-08-30 |
Family
ID=9075312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7113296A Granted FR2133503A1 (en) | 1971-04-15 | 1971-04-15 | 2-(1-phenylpyrazol-4-yl)propionic acids - with antiinflammatory analgesic and antirheumatic activity |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2133503A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4325962A (en) * | 1969-09-12 | 1982-04-20 | Byk-Gulden Lomberg Chemische Fabrik Gmbh | Pharmaceutical compositions comprising a pyrazole derivative and method of use |
EP0299504A1 (en) * | 1987-07-17 | 1989-01-18 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | A process for the preparation of 1-phenyl-3-(4-chlorophenyl)-pyrazol-4-ylacetic acid and its calcium salt |
-
1971
- 1971-04-15 FR FR7113296A patent/FR2133503A1/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4325962A (en) * | 1969-09-12 | 1982-04-20 | Byk-Gulden Lomberg Chemische Fabrik Gmbh | Pharmaceutical compositions comprising a pyrazole derivative and method of use |
EP0299504A1 (en) * | 1987-07-17 | 1989-01-18 | SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu | A process for the preparation of 1-phenyl-3-(4-chlorophenyl)-pyrazol-4-ylacetic acid and its calcium salt |
Also Published As
Publication number | Publication date |
---|---|
FR2133503B1 (en) | 1974-08-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO891523D0 (en) | ALFA-SUBSTITUTED 4- (QUINOLIN-2-YL-METOXY) PHENYL-ACETIC ACID ROG ESTERS. | |
SE8101064L (en) | TOPICAL PHARMACEUTICAL PREPARATIONS CONTAINING SALTS OF ALKANO CARBON ACIDS AND NEW CARBON ACID SALTS AND PROCEDURES FOR PREPARING THEREOF | |
FI920732A (en) | 2-SUBSTITUERADE KINOLINER, FOERFARANDE FOER FRAMSTAELLNING AV DESSA OCH ANVAENDNING AV DESSA I CEILING MODEL | |
ES346582A1 (en) | Substituted phenylacetic acids and esters thereof | |
FR2133503A1 (en) | 2-(1-phenylpyrazol-4-yl)propionic acids - with antiinflammatory analgesic and antirheumatic activity | |
ES398803A1 (en) | 2-substituted phenyl propionic acids | |
FR2047882A1 (en) | Analgesic antiinflammatory 4-(2-alkoxy - phenylamino-quinolines and intermediates | |
FR2306690A1 (en) | Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents | |
FR2194422A2 (en) | 3-(Trifluoromethoxy benzoyl) phenyl acetic acids and esters - with analgesic and antiinflammatory activity | |
FR2291745A1 (en) | Anti-inflammatory alpha-methyl-chromone-6-acetic acid derivs - produced by methylation of alpha-unsubstd. cpds. (BE190576) | |
ES435566A1 (en) | Disubstituted xanthone carboxylic acid compounds | |
CH559159A5 (en) | Analgesic anti-inflammatory alpha-phenyl fatty acids | |
FR2143577A1 (en) | 3-(2-chlorobenzamido)benzoic acids and salts - with uricosuric activity | |
FR2310986A2 (en) | D-Carbamylamino acids and D-amino acids useful as intermediates - prepd. by enzymic hydrolysis of substd. phenyl hydantoin and opt. further hydrolysis | |
FR2232305A1 (en) | 3-(4-Biphenylyl)-propionic acids - prepd. by hydrogenation of corresp. unsatd. cpd | |
FR2034121A7 (en) | Substd phenylacetic acid derivs analgesic antipyretic an - tiphlogistic | |
FR2163875A5 (en) | 3-benzoylphenyl acetic and 2-(3-benzoyl phenyl) - propionic acids prepn - for use as anti-inflammatories | |
FR2238485A1 (en) | Anti-inflammatory and analgesic glyceryl esters - of substd 4-phenyl-butyric and 4-phenyl-4-oxobutyric acids | |
FR2368273A1 (en) | Analgesic and antiinflammatory phenyl ethanol derivs. - show reduced irritant effect on mucous membranes | |
ES435672A1 (en) | Xanthone carboxylic acids and derivatives | |
FR2202873A2 (en) | 3-benzoylphenyl acetic and 2-(3-benzoyl phenyl) - propionic acids prepn - for use as anti-inflammatories | |
ES345831A1 (en) | A Process for the Production of Substituted Phenyl Acetic Acids | |
FR2269330A2 (en) | 4-(3-Benzoylphenyl)butyric acids - with antiinflammatory and analgesic activity | |
ES450125A1 (en) | 6,11-dihydro-11 - oxodibenzyloxepinealkanoic acids and esters | |
FR2077856A1 (en) | 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |