FR2105603A5 - Corticosteroids microbiological 1,2-dehydrogenation - Google Patents
Corticosteroids microbiological 1,2-dehydrogenationInfo
- Publication number
- FR2105603A5 FR2105603A5 FR7033275A FR7033275A FR2105603A5 FR 2105603 A5 FR2105603 A5 FR 2105603A5 FR 7033275 A FR7033275 A FR 7033275A FR 7033275 A FR7033275 A FR 7033275A FR 2105603 A5 FR2105603 A5 FR 2105603A5
- Authority
- FR
- France
- Prior art keywords
- dehydrogenation
- steroid
- induction
- culture
- corticosteroids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/02—Dehydrogenating; Dehydroxylating
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
In a process for 1,2-dehydrogenation of corticosteroids with Arthrobacter or Corynebacterium species involving enzyme-induction subsequent to cultivation but prior to dehydrogenation, the induction of the steroid 1,2-dehydrogenase is begun by addition of 0.02-0.2 mg/ml of a steroid of the androstane or pregnane series only after the growth of the bacteria in the stationary phase of the culture, an amount of a C- and /or N-source such as to give a 0.01-0.1% concentration being simultaneously added to the culture so as to give rise to a secondary growth. A 1,2-satd. corticosteroid is added to the resulting highly active culture (which can be diluted before the addition), the dehydrogenation and the isolation of the product being effected in a conventional manner. The new method of induction gives very high enzyme levels, and the dehydrogenation proceeds extremely rapidly and is unaccompanied by steroid degradation or reduction.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7033275A FR2105603A5 (en) | 1970-09-14 | 1970-09-14 | Corticosteroids microbiological 1,2-dehydrogenation |
| NLAANVRAGE7013857,A NL173068C (en) | 1970-09-14 | 1970-09-18 | METHOD FOR MICROBIOLOGICAL DEHYDROGENATION OF CORTICOSTEROIDS IN PLACE 1: 2. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7033275A FR2105603A5 (en) | 1970-09-14 | 1970-09-14 | Corticosteroids microbiological 1,2-dehydrogenation |
| NLAANVRAGE7013857,A NL173068C (en) | 1970-09-14 | 1970-09-18 | METHOD FOR MICROBIOLOGICAL DEHYDROGENATION OF CORTICOSTEROIDS IN PLACE 1: 2. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2105603A5 true FR2105603A5 (en) | 1972-04-28 |
Family
ID=34913615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7033275A Expired FR2105603A5 (en) | 1970-09-14 | 1970-09-14 | Corticosteroids microbiological 1,2-dehydrogenation |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR2105603A5 (en) |
| NL (1) | NL173068C (en) |
-
1970
- 1970-09-14 FR FR7033275A patent/FR2105603A5/en not_active Expired
- 1970-09-18 NL NLAANVRAGE7013857,A patent/NL173068C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7013857A (en) | 1972-03-21 |
| NL173068C (en) | 1983-12-01 |
| NL173068B (en) | 1983-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |