FR2081401A1 - Antiviral bis-benzimidazole derivs - Google Patents

Antiviral bis-benzimidazole derivs

Info

Publication number
FR2081401A1
FR2081401A1 FR7046228A FR7046228A FR2081401A1 FR 2081401 A1 FR2081401 A1 FR 2081401A1 FR 7046228 A FR7046228 A FR 7046228A FR 7046228 A FR7046228 A FR 7046228A FR 2081401 A1 FR2081401 A1 FR 2081401A1
Authority
FR
France
Prior art keywords
antiviral
bis
och3
derivs
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7046228A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of FR2081401A1 publication Critical patent/FR2081401A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Antiviral bis-benzimidazole derivs Title cpds. of formula (I) (where R is 1-4C alkoxy, R1 is H or OCH3 and R2 is H, OH or 1-4C alkyl; R1 not being OCH3 where R is OH) are useful for the treatment or prevention of infections by picorna viruses. (i.e. rhino-, Coxsackie and polio) and influenza viruses. They are prepd by reaction of corr. subst. o-phenylenediamines with dibasic acids in hydrochloric acid solution.
FR7046228A 1969-12-29 1970-12-22 Antiviral bis-benzimidazole derivs Withdrawn FR2081401A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88890269A 1969-12-29 1969-12-29

Publications (1)

Publication Number Publication Date
FR2081401A1 true FR2081401A1 (en) 1971-12-03

Family

ID=25394139

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7046228A Withdrawn FR2081401A1 (en) 1969-12-29 1970-12-22 Antiviral bis-benzimidazole derivs

Country Status (4)

Country Link
CH (1) CH535771A (en)
DE (1) DE2063856A1 (en)
FR (1) FR2081401A1 (en)
ZA (1) ZA708089B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019772A1 (en) * 1994-01-20 1995-07-27 The University Of North Carolina At Chapel Hill Use of bis(amidinobenzimidazoles) in the manufacture of medicament for inhibiting retroviral integrase
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2593737A (en) * 2020-03-31 2021-10-06 Sumitomo Chemical Co Polymer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019772A1 (en) * 1994-01-20 1995-07-27 The University Of North Carolina At Chapel Hill Use of bis(amidinobenzimidazoles) in the manufacture of medicament for inhibiting retroviral integrase
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US5843980A (en) * 1995-11-16 1998-12-01 Georgia State University Research Foundation, Inc. Benzamidoxime prodrugs as antipneumocystic agents
US6025398A (en) * 1995-11-16 2000-02-15 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US6423737B2 (en) 1995-11-16 2002-07-23 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Also Published As

Publication number Publication date
DE2063856A1 (en) 1971-07-01
CH535771A (en) 1973-04-15
ZA708089B (en) 1971-08-25

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Legal Events

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ST Notification of lapse