FR13C0040I1 - - Google Patents
Info
- Publication number
- FR13C0040I1 FR13C0040I1 FR13C0040C FR13C0040I1 FR 13C0040 I1 FR13C0040 I1 FR 13C0040I1 FR 13C0040 C FR13C0040 C FR 13C0040C FR 13C0040 I1 FR13C0040 I1 FR 13C0040I1
- Authority
- FR
- France
- Prior art keywords
- protein
- antigens
- nada
- subject
- antibody response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, after administration to a subject, is able to induce an antibody response in that subject, wherein the antibody response is bactericidal against two or three of hypervirulent lineages A4, ET 5 and lineage 3 of N.meningitidis serogroup B. Rather than consisting of a single antigen, the composition comprises a mixture of 10 or fewer purified antigens, and should not include complex or undefined mixtures of antigens such as outer membrane vesicles. Five protein antigens are used in particular: (1) a 'NadA' protein; (2) a '741' protein; (3) a '936' protein; (4) a '953' protein; and (5) a '287' protein. Oligomeric 'NadA' is particularly useful.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0223741A GB0223741D0 (en) | 2002-10-11 | 2002-10-11 | Composition with five meningococcal antigens |
GB0305831A GB0305831D0 (en) | 2003-03-13 | 2003-03-13 | Broad protection meningococcal vaccines |
GB0309115A GB0309115D0 (en) | 2003-04-22 | 2003-04-22 | Broad protection meningococcal vaccines |
PCT/IB2003/004848 WO2004032958A1 (en) | 2002-10-11 | 2003-10-02 | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
Publications (2)
Publication Number | Publication Date |
---|---|
FR13C0040I1 true FR13C0040I1 (en) | 2013-08-23 |
FR13C0040I2 FR13C0040I2 (en) | 2014-05-16 |
Family
ID=32096623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR13C0040C Active FR13C0040I2 (en) | 2002-10-11 | 2013-07-11 | POLYPEPTIDE VACCINES OFFERING BROAD PROTECTION AGAINST HYPERVIRULENT MENINGOCOCCAL LINES |
Country Status (22)
Country | Link |
---|---|
US (2) | US8663656B2 (en) |
EP (3) | EP2351579B1 (en) |
JP (4) | JP4697706B2 (en) |
CN (1) | CN1809380B (en) |
AT (1) | ATE492288T1 (en) |
AU (1) | AU2003274511B2 (en) |
BE (1) | BE2013C042I2 (en) |
BR (1) | BRPI0315228A8 (en) |
CA (1) | CA2501812C (en) |
CY (4) | CY1111341T1 (en) |
DE (1) | DE60335477D1 (en) |
DK (3) | DK2351579T3 (en) |
ES (2) | ES2775098T3 (en) |
FR (1) | FR13C0040I2 (en) |
HU (3) | HUE031886T2 (en) |
LU (1) | LU92241I2 (en) |
MX (1) | MXPA05003863A (en) |
NL (1) | NL300604I2 (en) |
NZ (1) | NZ562998A (en) |
PT (3) | PT2353608T (en) |
SI (3) | SI2351579T1 (en) |
WO (1) | WO2004032958A1 (en) |
Families Citing this family (95)
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US10967045B2 (en) * | 1998-11-02 | 2021-04-06 | Secretary of State for Health and Social Care | Multicomponent meningococcal vaccine |
PT1228217E (en) | 1999-04-30 | 2013-01-28 | Novartis Vaccines & Diagnostic | Conserved neisserial antigens |
CA2929348A1 (en) * | 1999-05-19 | 2000-11-30 | Novartis Vaccines And Diagnostics S.R.L. | Combination neisserial compositions |
ES2564463T3 (en) | 1999-10-29 | 2016-03-22 | Glaxosmithkline Biologicals S.A. | Neisserial antigenic peptides |
GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
BRPI0107679B8 (en) | 2000-01-17 | 2021-05-25 | Chiron Spa | composition comprising Neisseria meningitidis serum group b outer membrane vesicles and an inorganic component and use thereof |
CN100339482C (en) | 2000-02-28 | 2007-09-26 | 启龙股份公司 | Hybrid expression of neisserial proteins |
AU2001280883A1 (en) * | 2000-07-27 | 2002-02-13 | The Children's Hospital & Research Center At Oakland | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
BR0211494A (en) | 2001-07-27 | 2004-08-17 | Chiron Srl | Meningococcal adhesins nothing, app and orf 40 |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
MX339524B (en) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
JP4646516B2 (en) * | 2002-02-20 | 2011-03-09 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Fine particles with adsorbed polypeptide-containing molecules |
NZ574530A (en) * | 2002-08-02 | 2010-12-24 | Glaxosmithkline Biolog Sa | Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB-neisseria minigitidis |
EP2351579B1 (en) | 2002-10-11 | 2016-09-21 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
ATE552844T1 (en) | 2003-01-30 | 2012-04-15 | Novartis Ag | INJECTABLE VACCINE AGAINST MULTIPLE MENINGOCOCC SEROGROUPES |
BR122017002991B1 (en) | 2003-10-02 | 2023-01-10 | Novartis Vaccines And Diagnostics S.R.L. | AQUEOUS IMMUNOGENIC COMPOSITIONS FOR MULTIPLE MENINGOCOCCAL SEROGROUPS |
AU2011224064A1 (en) * | 2003-10-02 | 2011-10-06 | Novartis Vaccines And Diagnostics S.R.L. | Liquid vaccines for multiple meningococcal serogroups |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
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GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
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