WO2002034773A3 - Streptococcal genes - Google Patents

Streptococcal genes Download PDF

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Publication number
WO2002034773A3
WO2002034773A3 PCT/GB2001/004749 GB0104749W WO0234773A3 WO 2002034773 A3 WO2002034773 A3 WO 2002034773A3 GB 0104749 W GB0104749 W GB 0104749W WO 0234773 A3 WO0234773 A3 WO 0234773A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
streptococcal genes
vaccines
peptides
streptococcal
Prior art date
Application number
PCT/GB2001/004749
Other languages
French (fr)
Other versions
WO2002034773A2 (en
Inventor
David William Holden
Jeremy Stuart Brown
Original Assignee
Imp College Innovations Ltd
David William Holden
Jeremy Stuart Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0026231A external-priority patent/GB0026231D0/en
Priority claimed from GB0028345A external-priority patent/GB0028345D0/en
Priority claimed from GB0102666A external-priority patent/GB0102666D0/en
Application filed by Imp College Innovations Ltd, David William Holden, Jeremy Stuart Brown filed Critical Imp College Innovations Ltd
Priority to CA002426738A priority Critical patent/CA2426738A1/en
Priority to EP01976527A priority patent/EP1330473A2/en
Priority to US10/415,478 priority patent/US20040116661A1/en
Priority to JP2002537762A priority patent/JP4183504B2/en
Priority to AU2001295795A priority patent/AU2001295795A1/en
Publication of WO2002034773A2 publication Critical patent/WO2002034773A2/en
Publication of WO2002034773A3 publication Critical patent/WO2002034773A3/en
Priority to US11/941,513 priority patent/US20090280141A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Peptides derived from S. pneumoniae are identified as virulence determinants and may be useful in the preparation of vaccines for the treatment of infection. The peptides may be used as antigens or in the preparation of attenuated microorganisms for use as live oral vaccines.
PCT/GB2001/004749 2000-10-26 2001-10-26 Streptococcal genes WO2002034773A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002426738A CA2426738A1 (en) 2000-10-26 2001-10-26 Streptococcal genes
EP01976527A EP1330473A2 (en) 2000-10-26 2001-10-26 Streptococcal genes
US10/415,478 US20040116661A1 (en) 2000-10-26 2001-10-26 Streptococcal genes
JP2002537762A JP4183504B2 (en) 2000-10-26 2001-10-26 Streptococcus gene
AU2001295795A AU2001295795A1 (en) 2000-10-26 2001-10-26 Streptococcal genes
US11/941,513 US20090280141A1 (en) 2000-10-26 2007-11-16 Streptococcal Genes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0026231.1 2000-10-26
GB0026231A GB0026231D0 (en) 2000-10-26 2000-10-26 Streptococcal genes
GB0028345.7 2000-11-21
GB0028345A GB0028345D0 (en) 2000-11-21 2000-11-21 Streptococcal genes
GB0102666.5 2001-02-02
GB0102666A GB0102666D0 (en) 2001-02-02 2001-02-02 Streptococcal Genes
US28811801P 2001-05-02 2001-05-02
US60/288,118 2001-05-02

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/941,513 Continuation US20090280141A1 (en) 2000-10-26 2007-11-16 Streptococcal Genes

Publications (2)

Publication Number Publication Date
WO2002034773A2 WO2002034773A2 (en) 2002-05-02
WO2002034773A3 true WO2002034773A3 (en) 2003-03-13

Family

ID=27447899

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/004749 WO2002034773A2 (en) 2000-10-26 2001-10-26 Streptococcal genes

Country Status (4)

Country Link
EP (1) EP1330473A2 (en)
AU (1) AU2001295795A1 (en)
CA (1) CA2426738A1 (en)
WO (1) WO2002034773A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0208499D0 (en) * 2002-04-12 2002-05-22 Microscience Ltd Streptococcal genes
EP1670505B1 (en) 2003-09-18 2012-11-14 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Dna promoters and anthrax vaccines
US8729013B2 (en) 2004-08-26 2014-05-20 The University Of Western Ontario Methods of inhibiting staphylobactin-mediated iron uptake in S. aureus
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
AU2009222105B2 (en) 2008-03-03 2012-05-17 Novartis Ag Compounds and compositions as TLR activity modulators
RU2556813C2 (en) * 2009-02-20 2015-07-20 Острэйлиан Паултри Срс Пти Лимитед Live attenuated vaccines
US9517263B2 (en) 2009-06-10 2016-12-13 Glaxosmithkline Biologicals Sa Benzonaphthyridine-containing vaccines
JO3257B1 (en) 2009-09-02 2018-09-16 Novartis Ag Compounds and compositions as tlr activity modulators
CN102844047B (en) 2009-09-02 2017-04-05 诺华股份有限公司 Immunogenic composition containing TLR active regulators
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
JP5814933B2 (en) 2009-12-15 2015-11-17 ノバルティス アーゲー Homogeneous suspension of immune enhancing compounds and uses thereof
KR101853513B1 (en) 2010-03-23 2018-04-30 노파르티스 아게 Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.
US20150132339A1 (en) 2012-03-07 2015-05-14 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
CA2899787A1 (en) 2013-02-01 2014-08-07 Glaxosmithkline Biologicals Sa Intradermal delivery of immunological compositions comprising toll-like receptor agonists
US11098349B2 (en) * 2015-11-04 2021-08-24 The Translational Genomics Research Institute Systems and methods of diagnosing and characterizing infections
JP7362667B2 (en) 2018-02-12 2023-10-17 イニミューン・コーポレーション Toll-like receptor ligand
JP2023547677A (en) 2020-11-04 2023-11-13 エリゴ・バイオサイエンス Cutibacterium acnes recombinant phage, its production method and use
GB2600962A (en) * 2020-11-12 2022-05-18 Ucl Business Plc Live attenuated strain of Streptococcus pneumoniae and pharmaceutical compositions comprising a live attenuated strain of S. pneumoniae

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998023631A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Corporation Novel bacterial polypeptides and polynucleotides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434065A (en) * 1993-05-06 1995-07-18 President And Fellows Of Harvard College In vivo selection of microbial virulence genes
WO1998006734A1 (en) * 1996-08-16 1998-02-19 Smithkline Beecham Corporation Novel prokaryotic polynucleotides, polypeptides and their uses
WO1998018930A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
WO1998023631A1 (en) * 1996-11-27 1998-06-04 Smithkline Beecham Corporation Novel bacterial polypeptides and polynucleotides

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BROWN J S ET AL: "A STREPTOCOCCUS PNEUMONIAE PATHOGENICITY ISLAND ENCODING AN ABC TRANSPORTER INVOLVED IN IRON UPTAKE AND VIRULENCE", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, VOL. 40, NR. 3, PAGE(S) 572-585, ISSN: 0950-382X, XP001057233 *
DATABASE EMBL 17 October 1998 (1998-10-17), XP002191216 *
DATABASE EMBL 3 February 1992 (1992-02-03), XP002191215 *
DATABASE EMBL 31 July 2001 (2001-07-31), XP002191217 *
DATABASE EMBL XP002198687 *
FONTAN P A ET AL: "B-437. A CHOLINE TRANSPORTER AS A VIRULENCE DETERMINANT OF STREPTOCOCCUS PNEUMONIAE", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, VOL. 97, NR. 97, PAGE(S) 103, ISSN: 0067-2777, XP000892162 *
SPELLERBERG B ET AL: "PYRUVATE OXIDASE, AS A DETERMINANT OF VIRULENCE IN STREPTOCOCCUS PNEUMONIAE", MOLECULAR MICROBIOLOGY, BLACKWELL SCIENTIFIC, OXFORD, GB, VOL. 19, NR. 4, PAGE(S) 803-813, ISSN: 0950-382X, XP002070537 *

Also Published As

Publication number Publication date
WO2002034773A2 (en) 2002-05-02
CA2426738A1 (en) 2002-05-02
EP1330473A2 (en) 2003-07-30
AU2001295795A1 (en) 2002-05-06

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