BRPI0315228A8 - Polypeptide vaccines for broad protection against hypervirulent meningococcal strains - Google Patents

Polypeptide vaccines for broad protection against hypervirulent meningococcal strains

Info

Publication number
BRPI0315228A8
BRPI0315228A8 BRPI0315228A BR0315228A BRPI0315228A8 BR PI0315228 A8 BRPI0315228 A8 BR PI0315228A8 BR PI0315228 A BRPI0315228 A BR PI0315228A BR 0315228 A BR0315228 A BR 0315228A BR PI0315228 A8 BRPI0315228 A8 BR PI0315228A8
Authority
BR
Brazil
Prior art keywords
protein
protection against
antigens
broad protection
polypeptide vaccines
Prior art date
Application number
BRPI0315228A
Other languages
Portuguese (pt)
Other versions
BR0315228A (en
Inventor
Pizza Mariagrazia
Original Assignee
Chiron Srl
Novartis Vaccines & Diagnostics S R L
Gsk Vaccines S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0223741A external-priority patent/GB0223741D0/en
Priority claimed from GB0305831A external-priority patent/GB0305831D0/en
Priority claimed from GB0309115A external-priority patent/GB0309115D0/en
Application filed by Chiron Srl, Novartis Vaccines & Diagnostics S R L, Gsk Vaccines S R L filed Critical Chiron Srl
Publication of BR0315228A publication Critical patent/BR0315228A/en
Publication of BRPI0315228A8 publication Critical patent/BRPI0315228A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

VACINAS DE POLIPEPTÍDEO PARA AMPLA PROTEÇÃO CONTRA LINHAGENS MENINGOCÓCICAS HIPERVIRULENTAS. Um pequeno número de antígenos definido pode fornecer ampla proteção contra infecção meningocócica, e a invenção fornece uma composição que, após a administração a um indivíduo, é capaz de induzir uma resposta de anticorpo naquele indivíduo, onde a resposta do anticorpo é bactericida contra duas ou mais linhagens hipervirulentas A4, ET5 e a linhagem 3 de N. meningitidis do sorogrupo B. Em vez de consistir de um antígeno único, a composição compreende uma mistura de 10 ou menos antígenos purificados, e não deve incluir misturas complexas ou não definidas de antígenos tais como vesículas de membrana externa. Cinco antígenos de proteína são usados, particularmente: (1) uma proteína 'NadA'; (2) uma proteína'741' ; (3) uma proteína '936'; (4) uma proteína '953'; e (5) uma proteína '287'.POLYPEPTIDE VACCINES FOR BROAD PROTECTION AGAINST HYPERVIRUENT MENINGOCOCCAL LINEAGES. A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, upon administration to an individual, is capable of eliciting an antibody response in that individual, where the antibody response is bactericidal against two or more plus hypervirulent strains A4, ET5, and serogroup B N. meningitidis strain 3. Rather than consisting of a single antigen, the composition comprises a mixture of 10 or fewer purified antigens, and should not include complex or undefined mixtures of antigens such as outer membrane vesicles. Five protein antigens are used, particularly: (1) a 'NadA' protein; (2) a '741' protein; (3) a '936' protein; (4) a '953' protein; and (5) a '287' protein.

BRPI0315228A 2002-10-11 2003-10-02 Polypeptide vaccines for broad protection against hypervirulent meningococcal strains BRPI0315228A8 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0223741A GB0223741D0 (en) 2002-10-11 2002-10-11 Composition with five meningococcal antigens
GB0305831A GB0305831D0 (en) 2003-03-13 2003-03-13 Broad protection meningococcal vaccines
GB0309115A GB0309115D0 (en) 2003-04-22 2003-04-22 Broad protection meningococcal vaccines
PCT/IB2003/004848 WO2004032958A1 (en) 2002-10-11 2003-10-02 Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages

Publications (2)

Publication Number Publication Date
BR0315228A BR0315228A (en) 2006-04-11
BRPI0315228A8 true BRPI0315228A8 (en) 2018-04-03

Family

ID=32096623

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0315228A BRPI0315228A8 (en) 2002-10-11 2003-10-02 Polypeptide vaccines for broad protection against hypervirulent meningococcal strains

Country Status (22)

Country Link
US (2) US8663656B2 (en)
EP (3) EP2351579B1 (en)
JP (4) JP4697706B2 (en)
CN (1) CN1809380B (en)
AT (1) ATE492288T1 (en)
AU (1) AU2003274511B2 (en)
BE (1) BE2013C042I2 (en)
BR (1) BRPI0315228A8 (en)
CA (1) CA2501812C (en)
CY (4) CY1111341T1 (en)
DE (1) DE60335477D1 (en)
DK (3) DK1549338T3 (en)
ES (2) ES2775098T3 (en)
FR (1) FR13C0040I2 (en)
HU (3) HUE047780T2 (en)
LU (1) LU92241I2 (en)
MX (1) MXPA05003863A (en)
NL (1) NL300604I2 (en)
NZ (1) NZ562998A (en)
PT (3) PT2353608T (en)
SI (3) SI2353608T1 (en)
WO (1) WO2004032958A1 (en)

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