BRPI0315228A8 - Polypeptide vaccines for broad protection against hypervirulent meningococcal strains - Google Patents
Polypeptide vaccines for broad protection against hypervirulent meningococcal strainsInfo
- Publication number
- BRPI0315228A8 BRPI0315228A8 BRPI0315228A BR0315228A BRPI0315228A8 BR PI0315228 A8 BRPI0315228 A8 BR PI0315228A8 BR PI0315228 A BRPI0315228 A BR PI0315228A BR 0315228 A BR0315228 A BR 0315228A BR PI0315228 A8 BRPI0315228 A8 BR PI0315228A8
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- protection against
- antigens
- broad protection
- polypeptide vaccines
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000427 antigen Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 230000005875 antibody response Effects 0.000 abstract 2
- 208000034762 Meningococcal Infections Diseases 0.000 abstract 1
- 241000588650 Neisseria meningitidis Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
VACINAS DE POLIPEPTÍDEO PARA AMPLA PROTEÇÃO CONTRA LINHAGENS MENINGOCÓCICAS HIPERVIRULENTAS. Um pequeno número de antígenos definido pode fornecer ampla proteção contra infecção meningocócica, e a invenção fornece uma composição que, após a administração a um indivíduo, é capaz de induzir uma resposta de anticorpo naquele indivíduo, onde a resposta do anticorpo é bactericida contra duas ou mais linhagens hipervirulentas A4, ET5 e a linhagem 3 de N. meningitidis do sorogrupo B. Em vez de consistir de um antígeno único, a composição compreende uma mistura de 10 ou menos antígenos purificados, e não deve incluir misturas complexas ou não definidas de antígenos tais como vesículas de membrana externa. Cinco antígenos de proteína são usados, particularmente: (1) uma proteína 'NadA'; (2) uma proteína'741' ; (3) uma proteína '936'; (4) uma proteína '953'; e (5) uma proteína '287'.POLYPEPTIDE VACCINES FOR BROAD PROTECTION AGAINST HYPERVIRUENT MENINGOCOCCAL LINEAGES. A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, upon administration to an individual, is capable of eliciting an antibody response in that individual, where the antibody response is bactericidal against two or more plus hypervirulent strains A4, ET5, and serogroup B N. meningitidis strain 3. Rather than consisting of a single antigen, the composition comprises a mixture of 10 or fewer purified antigens, and should not include complex or undefined mixtures of antigens such as outer membrane vesicles. Five protein antigens are used, particularly: (1) a 'NadA' protein; (2) a '741' protein; (3) a '936' protein; (4) a '953' protein; and (5) a '287' protein.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0223741A GB0223741D0 (en) | 2002-10-11 | 2002-10-11 | Composition with five meningococcal antigens |
GB0305831A GB0305831D0 (en) | 2003-03-13 | 2003-03-13 | Broad protection meningococcal vaccines |
GB0309115A GB0309115D0 (en) | 2003-04-22 | 2003-04-22 | Broad protection meningococcal vaccines |
PCT/IB2003/004848 WO2004032958A1 (en) | 2002-10-11 | 2003-10-02 | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0315228A BR0315228A (en) | 2006-04-11 |
BRPI0315228A8 true BRPI0315228A8 (en) | 2018-04-03 |
Family
ID=32096623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0315228A BRPI0315228A8 (en) | 2002-10-11 | 2003-10-02 | Polypeptide vaccines for broad protection against hypervirulent meningococcal strains |
Country Status (22)
Country | Link |
---|---|
US (2) | US8663656B2 (en) |
EP (3) | EP2353608B1 (en) |
JP (4) | JP4697706B2 (en) |
CN (1) | CN1809380B (en) |
AT (1) | ATE492288T1 (en) |
AU (1) | AU2003274511B2 (en) |
BE (1) | BE2013C042I2 (en) |
BR (1) | BRPI0315228A8 (en) |
CA (1) | CA2501812C (en) |
CY (4) | CY1111341T1 (en) |
DE (1) | DE60335477D1 (en) |
DK (3) | DK2353608T3 (en) |
ES (2) | ES2608048T3 (en) |
FR (1) | FR13C0040I2 (en) |
HU (3) | HUE047780T2 (en) |
LU (1) | LU92241I2 (en) |
MX (1) | MXPA05003863A (en) |
NL (1) | NL300604I2 (en) |
NZ (1) | NZ562998A (en) |
PT (3) | PT2353608T (en) |
SI (3) | SI2351579T1 (en) |
WO (1) | WO2004032958A1 (en) |
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ES2563677T3 (en) * | 1999-05-19 | 2016-03-15 | Glaxosmithkline Biologicals Sa | Compositions of combinations of Neisseria |
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NZ521396A (en) | 2000-02-28 | 2004-06-25 | Chiron S | Fusion proteins comprising two or more Neisseria polypeptides |
BRPI0112928B1 (en) * | 2000-07-27 | 2017-08-29 | Children's Hospital & Research Center At Oakland | A composition comprising preparations comprising outer membrane vesicles (OMV), microvesicles (MV) or both MVO and MV |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
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