FI98932B - Menetelmä monistetun DNA-näytteen aiheuttaman kontaminaation pienentämiseksi amplifikaatiomenetelmässä - Google Patents
Menetelmä monistetun DNA-näytteen aiheuttaman kontaminaation pienentämiseksi amplifikaatiomenetelmässäInfo
- Publication number
- FI98932B FI98932B FI916171A FI916171A FI98932B FI 98932 B FI98932 B FI 98932B FI 916171 A FI916171 A FI 916171A FI 916171 A FI916171 A FI 916171A FI 98932 B FI98932 B FI 98932B
- Authority
- FI
- Finland
- Prior art keywords
- dna sample
- amplified dna
- contamination caused
- reducing contamination
- amplification method
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 230000003321 amplification Effects 0.000 title 1
- 238000011109 contamination Methods 0.000 title 1
- 238000003199 nucleic acid amplification method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6862—Ligase chain reaction [LCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Microwave Amplifiers (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51763190A | 1990-05-01 | 1990-05-01 | |
| US51763190 | 1990-05-01 | ||
| US68647891A | 1991-04-19 | 1991-04-19 | |
| US68647891 | 1991-04-19 | ||
| PCT/US1991/003052 WO1991017270A1 (en) | 1990-05-01 | 1991-04-30 | Method for reducing carryover contamination in an amplification procedure |
| US9103052 | 1991-04-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI916171A0 FI916171A0 (fi) | 1991-12-31 |
| FI98932B true FI98932B (fi) | 1997-05-30 |
| FI98932C FI98932C (fi) | 1997-09-10 |
Family
ID=27059197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI916171A FI98932C (fi) | 1990-05-01 | 1991-12-31 | Menetelmä monistetun DNA-näytteen aiheuttaman kontaminaation pienentämiseksi amplifikaatiomenetelmässä |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5427929A (fi) |
| EP (1) | EP0481069A4 (fi) |
| JP (2) | JPH04506906A (fi) |
| KR (1) | KR920702726A (fi) |
| CN (1) | CN1059562A (fi) |
| BR (1) | BR9105737A (fi) |
| CA (1) | CA2063432A1 (fi) |
| FI (1) | FI98932C (fi) |
| HU (1) | HU218095B (fi) |
| IE (1) | IE911456A1 (fi) |
| IL (1) | IL97981A (fi) |
| NO (1) | NO305962B1 (fi) |
| NZ (1) | NZ237996A (fi) |
| PT (1) | PT97534B (fi) |
| WO (1) | WO1991017270A1 (fi) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5035996A (en) * | 1989-06-01 | 1991-07-30 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
| US5683896A (en) * | 1989-06-01 | 1997-11-04 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
| US5516663A (en) * | 1990-01-26 | 1996-05-14 | Abbott Laboratories | Ligase chain reaction with endonuclease IV correction and contamination control |
| US5516292A (en) * | 1991-05-02 | 1996-05-14 | The Research Foundation Of State University Of New York | Primer directed nucleic acid amplification including the addition of specific template DNA inactivating enzyme |
| US6180338B1 (en) | 1992-08-04 | 2001-01-30 | Beckman Coulter, Inc. | Method, reagent and kit for the detection and amplification of nucleic acid sequences |
| US6207368B1 (en) | 1992-08-04 | 2001-03-27 | Beckman Coulter, Inc. | Methods and reagents for controlling chain extension and ligation chain reactions |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| US5591575A (en) * | 1993-04-07 | 1997-01-07 | Amersham International Plc | Subtraction hybridization employing aziridinylbenoquinone cross-linking agents |
| US5462854A (en) * | 1993-04-19 | 1995-10-31 | Beckman Instruments, Inc. | Inverse linkage oligonucleotides for chemical and enzymatic processes |
| US5605796A (en) * | 1994-07-19 | 1997-02-25 | Behringwerke Ag | Method for preventing amplification of nucleic acid contaminants in amplification mixtures using nuclease-receptor conjugates |
| ZA956776B (en) | 1994-08-25 | 1996-03-20 | Akzo Nobel Nv | A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay |
| US5843650A (en) * | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
| US5830655A (en) * | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5932450A (en) * | 1995-06-07 | 1999-08-03 | Gen-Probe Incorporated | Enzymatic synthesis of oligonucleotides using digestible templates |
| CA2223050A1 (en) * | 1995-06-07 | 1996-12-19 | Abbott Laboratories | Probe masking method of reducing background in an amplification reaction |
| US5916777A (en) * | 1995-06-07 | 1999-06-29 | Gen-Probe Incorporated | Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers |
| SE504798C2 (sv) * | 1995-06-16 | 1997-04-28 | Ulf Landegren | Immunanalys och testkit med två reagens som kan tvärbindas om de adsorberats till analyten |
| CA2270132A1 (en) * | 1996-11-06 | 1998-05-14 | Sequenom, Inc. | Dna diagnostics based on mass spectrometry |
| WO1998026095A1 (en) * | 1996-12-10 | 1998-06-18 | Genetrace Systems Inc. | Releasable nonvolatile mass-label molecules |
| IL121312A (en) * | 1997-07-14 | 2001-09-13 | Technion Res & Dev Foundation | Microelectronic components, their manufacture and electronic networks containing them |
| CA2307177C (en) | 1997-10-23 | 2004-06-29 | Exact Laboratories, Inc. | Methods for detecting contamination in molecular diagnostics using pcr |
| US6818404B2 (en) | 1997-10-23 | 2004-11-16 | Exact Sciences Corporation | Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples |
| US6437099B1 (en) * | 1998-01-07 | 2002-08-20 | Hamamatsu Photonics K.K. | Fluorescene—activating antisera and IgG fraction therefrom |
| US6019839A (en) * | 1998-04-17 | 2000-02-01 | Applied Materials, Inc. | Method and apparatus for forming an epitaxial titanium silicide film by low pressure chemical vapor deposition |
| US20030203394A1 (en) * | 1998-05-04 | 2003-10-30 | Yoav Eichen | Detection of a target in a sample |
| WO2000006779A1 (en) | 1998-07-31 | 2000-02-10 | Gen-Probe Incorporated | Reversible inhibiting probes |
| IL126776A (en) | 1998-10-27 | 2001-04-30 | Technion Res & Dev Foundation | A method of investing gold |
| AU773978B2 (en) * | 1999-04-07 | 2004-06-10 | Dennis Michael Connolly | High resolution DNA detection methods and devices |
| US6232104B1 (en) | 1999-08-17 | 2001-05-15 | Dade Behring Inc. | Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration |
| US6383755B1 (en) * | 1999-09-08 | 2002-05-07 | Clontech Laboratories, Inc. | Methods and kits for determining the fidelity of polymerase chain reaction conditions |
| US6692918B2 (en) * | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| US6251639B1 (en) | 1999-09-13 | 2001-06-26 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences, using a RNA-DNA composite primer |
| US7364920B2 (en) * | 1999-10-27 | 2008-04-29 | Technion Research And Development Foundation Ltd. | Method for gold deposition |
| EP1152058A1 (en) * | 2000-05-03 | 2001-11-07 | Institut Curie | Methods and compositions for effecting homologous recombination |
| WO2001096607A2 (en) | 2000-06-13 | 2001-12-20 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
| JP2004513617A (ja) * | 2000-06-26 | 2004-05-13 | ニューゲン テクノロジーズ, インコーポレイテッド | 転写に基づく核酸増幅のための方法および組成物 |
| US7846733B2 (en) * | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| CA2389310A1 (en) * | 2000-08-30 | 2002-03-07 | Sanko Junyaku Co., Ltd. | Method of detecting gene |
| JP2004537257A (ja) | 2000-10-06 | 2004-12-16 | ニューゲン テクノロジーズ, インコーポレイテッド | 核酸配列の検出および/または定量のための、方法およびプローブ |
| AU2002228974A1 (en) | 2000-12-13 | 2002-06-24 | Nugen Technologies, Inc | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
| US6946251B2 (en) | 2001-03-09 | 2005-09-20 | Nugen Technologies, Inc. | Methods and compositions for amplification of RNA sequences using RNA-DNA composite primers |
| CA2439074A1 (en) * | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| US20030203384A1 (en) * | 2002-03-08 | 2003-10-30 | Chafin David R. | Multiplex detection of biological materials in a sample |
| US7176025B2 (en) * | 2002-03-11 | 2007-02-13 | Nugen Technologies, Inc. | Methods for generating double stranded DNA comprising a 3′ single stranded portion and uses of these complexes for recombination |
| EP1573056A4 (en) * | 2002-05-17 | 2007-11-28 | Nugen Technologies Inc | METHODS FOR FRAGMENTATION, LABELING AND IMMOBILIZATION OF NUCLEIC ACIDS |
| EP1587940A4 (en) * | 2002-12-20 | 2006-06-07 | Caliper Life Sciences Inc | SINGLE MOLECULAR AMPLIFICATION AND DNA PROOF |
| WO2004092418A2 (en) * | 2003-04-14 | 2004-10-28 | Nugen Technologies, Inc. | Global amplification using a randomly primed composite primer |
| WO2005065321A2 (en) | 2003-12-29 | 2005-07-21 | Nugen Technologies, Inc. | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
| EP1781813B1 (en) * | 2004-06-17 | 2010-01-27 | Epigenomics AG | Compositions and methods for preventing carry-over contamination in nucleic acid amplification reactions |
| EP1929046B1 (en) * | 2005-09-07 | 2012-07-11 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US7833716B2 (en) | 2006-06-06 | 2010-11-16 | Gen-Probe Incorporated | Tagged oligonucleotides and their use in nucleic acid amplification methods |
| US20100022403A1 (en) * | 2006-06-30 | 2010-01-28 | Nurith Kurn | Methods for fragmentation and labeling of nucleic acids |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
| US20090203531A1 (en) * | 2008-02-12 | 2009-08-13 | Nurith Kurn | Method for Archiving and Clonal Expansion |
| WO2009117698A2 (en) | 2008-03-21 | 2009-09-24 | Nugen Technologies, Inc. | Methods of rna amplification in the presence of dna |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| WO2012054639A2 (en) | 2010-10-22 | 2012-04-26 | T2 Biosystems, Inc. | Nmr systems and methods for the rapid detection of analytes |
| CN102827828B (zh) * | 2011-06-16 | 2014-06-11 | 华东医学生物技术研究所 | 一种基于IIs型限制性内切酶消除PCR扩增产物污染的方法 |
| SG11201401628WA (en) | 2011-10-19 | 2014-05-29 | Nugen Technologies Inc | Compositions and methods for directional nucleic acid amplification and sequencing |
| SG10201504490QA (en) | 2012-01-26 | 2015-07-30 | Nugen Technologies Inc | Compositions And Methods For Targeted Nucleic Acid Sequence Enrichment And High Efficiency Library Generation |
| US9957549B2 (en) | 2012-06-18 | 2018-05-01 | Nugen Technologies, Inc. | Compositions and methods for negative selection of non-desired nucleic acid sequences |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| US20140274738A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
| WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
| WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| CN112301102B (zh) * | 2019-07-31 | 2024-06-25 | 华南师范大学 | 一种高特异性的环介导等温扩增方法及其应用 |
| US12059674B2 (en) | 2020-02-03 | 2024-08-13 | Tecan Genomics, Inc. | Reagent storage system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4876187A (en) * | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| CA1323293C (en) * | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| DE68928853T2 (de) * | 1988-05-20 | 1999-08-05 | Cetus Corp., Emeryville, Calif. | Befestigung von sequenzspezifischen proben |
| US5035996A (en) * | 1989-06-01 | 1991-07-30 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
| FR2649122B1 (fr) * | 1989-07-03 | 1991-10-18 | Pasteur Institut | Perfectionnements apportes aux techniques d'amplification par reaction de polymerisation en chaine (pcr) |
| DK0415755T3 (da) * | 1989-09-01 | 1996-01-22 | Life Technologies Inc | Fremgangsmåde til bekæmpelse af kontaminering af oligonukleotidafhængige nukleinsyreamplifikationsreaktioner |
| WO1991006665A1 (en) * | 1989-10-26 | 1991-05-16 | Isaacs Stephen T | Activation compounds and methods for nucleic acid sterilization |
| WO1992018521A1 (en) * | 1991-04-10 | 1992-10-29 | Life Technologies, Inc. | Method for amplifying and altering an rna sequence |
-
1991
- 1991-04-19 HU HU9200301A patent/HU218095B/hu not_active IP Right Cessation
- 1991-04-28 IL IL9798191A patent/IL97981A/en not_active IP Right Cessation
- 1991-04-30 BR BR919105737A patent/BR9105737A/pt not_active Application Discontinuation
- 1991-04-30 WO PCT/US1991/003052 patent/WO1991017270A1/en not_active Ceased
- 1991-04-30 IE IE145691A patent/IE911456A1/en unknown
- 1991-04-30 CA CA002063432A patent/CA2063432A1/en not_active Abandoned
- 1991-04-30 NZ NZ237996A patent/NZ237996A/en unknown
- 1991-04-30 JP JP3509972A patent/JPH04506906A/ja active Pending
- 1991-04-30 PT PT97534A patent/PT97534B/pt active IP Right Grant
- 1991-04-30 CN CN91103775A patent/CN1059562A/zh active Pending
- 1991-04-30 KR KR1019910702023A patent/KR920702726A/ko not_active Abandoned
- 1991-04-30 EP EP19910910428 patent/EP0481069A4/en not_active Withdrawn
- 1991-12-30 NO NO915136A patent/NO305962B1/no not_active IP Right Cessation
- 1991-12-31 FI FI916171A patent/FI98932C/fi active
-
1993
- 1993-05-03 US US08/057,192 patent/US5427929A/en not_active Expired - Lifetime
-
1995
- 1995-01-23 US US08/376,762 patent/US5876976A/en not_active Expired - Fee Related
- 1995-01-23 US US08/376,763 patent/US6037152A/en not_active Expired - Fee Related
-
1999
- 1999-12-08 JP JP11348822A patent/JP2000125890A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HU9200301D0 (en) | 1992-04-28 |
| JP2000125890A (ja) | 2000-05-09 |
| US6037152A (en) | 2000-03-14 |
| FI916171A0 (fi) | 1991-12-31 |
| IE911456A1 (en) | 1991-11-06 |
| EP0481069A1 (en) | 1992-04-22 |
| BR9105737A (pt) | 1992-08-18 |
| WO1991017270A1 (en) | 1991-11-14 |
| IL97981A (en) | 1996-06-18 |
| AU636499B2 (en) | 1993-04-29 |
| US5876976A (en) | 1999-03-02 |
| HU218095B (hu) | 2000-05-28 |
| HUT60331A (en) | 1992-08-28 |
| NZ237996A (en) | 1993-11-25 |
| NO305962B1 (no) | 1999-08-23 |
| IL97981A0 (en) | 1992-06-21 |
| CN1059562A (zh) | 1992-03-18 |
| EP0481069A4 (en) | 1992-06-24 |
| NO915136L (no) | 1992-02-28 |
| NO915136D0 (no) | 1991-12-30 |
| FI98932C (fi) | 1997-09-10 |
| AU7987191A (en) | 1991-11-27 |
| PT97534A (pt) | 1993-09-30 |
| CA2063432A1 (en) | 1991-11-02 |
| JPH04506906A (ja) | 1992-12-03 |
| PT97534B (pt) | 1998-11-30 |
| KR920702726A (ko) | 1992-10-06 |
| US5427929A (en) | 1995-06-27 |
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