FI981799A - DNA-molekyylejä, jotka koodaavat CD25 sitovia molekyylejä - Google Patents

DNA-molekyylejä, jotka koodaavat CD25 sitovia molekyylejä Download PDF

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Publication number
FI981799A
FI981799A FI981799A FI981799A FI981799A FI 981799 A FI981799 A FI 981799A FI 981799 A FI981799 A FI 981799A FI 981799 A FI981799 A FI 981799A FI 981799 A FI981799 A FI 981799A
Authority
FI
Finland
Prior art keywords
molecules
antibodies
encoding
binding
dna
Prior art date
Application number
FI981799A
Other languages
English (en)
Swedish (sv)
Other versions
FI104047B (fi
FI981799A0 (fi
FI104047B1 (fi
Inventor
Peter Lloyd Amlot
Arne Nalpon Akbar
Guenther Heinrich
Salvatore Cammisuli
Original Assignee
Novartis Ag
Royal Free Hosp School Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26296798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI981799(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909005962A external-priority patent/GB9005962D0/en
Priority claimed from GB909019323A external-priority patent/GB9019323D0/en
Application filed by Novartis Ag, Royal Free Hosp School Med filed Critical Novartis Ag
Publication of FI981799A0 publication Critical patent/FI981799A0/fi
Publication of FI981799A publication Critical patent/FI981799A/fi
Application granted granted Critical
Publication of FI104047B publication Critical patent/FI104047B/fi
Publication of FI104047B1 publication Critical patent/FI104047B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI981799A 1990-03-16 1998-08-21 DNA-molekyylejä, jotka koodaavat CD25 sitovia molekyylejä FI104047B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9005962 1990-03-16
GB909005962A GB9005962D0 (en) 1990-03-16 1990-03-16 Improvements in or relating to organic compounds
GB9019323 1990-09-05
GB909019323A GB9019323D0 (en) 1990-09-05 1990-09-05 Improvements relating to immunosuppression
FI911275A FI103131B1 (fi) 1990-03-16 1991-03-14 Menetelmä CD25 sitovan molekyylin valmistamiseksi
FI911275 1991-03-14

Publications (4)

Publication Number Publication Date
FI981799A0 FI981799A0 (fi) 1998-08-21
FI981799A true FI981799A (fi) 1998-08-21
FI104047B FI104047B (fi) 1999-11-15
FI104047B1 FI104047B1 (fi) 1999-11-15

Family

ID=26296798

Family Applications (3)

Application Number Title Priority Date Filing Date
FI911275A FI103131B1 (fi) 1990-03-16 1991-03-14 Menetelmä CD25 sitovan molekyylin valmistamiseksi
FI981799A FI104047B1 (fi) 1990-03-16 1998-08-21 DNA-molekyylejä, jotka koodaavat CD25 sitovia molekyylejä
FI991788A FI19991788A (fi) 1990-03-16 1999-08-23 CD25 sitovia molekyylejä

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI911275A FI103131B1 (fi) 1990-03-16 1991-03-14 Menetelmä CD25 sitovan molekyylin valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI991788A FI19991788A (fi) 1990-03-16 1999-08-23 CD25 sitovia molekyylejä

Country Status (23)

Country Link
US (2) US6521230B1 (fi)
EP (1) EP0449769B1 (fi)
JP (1) JP2585475B2 (fi)
AT (1) ATE98655T1 (fi)
AU (1) AU635401B2 (fi)
CA (1) CA2038279C (fi)
CY (1) CY1977A (fi)
DE (2) DE19975033I2 (fi)
DK (1) DK0449769T3 (fi)
ES (1) ES2061216T3 (fi)
FI (3) FI103131B1 (fi)
HK (1) HK53797A (fi)
HU (2) HUT60768A (fi)
IE (1) IE65062B1 (fi)
IL (1) IL97545A (fi)
LU (1) LU90383I2 (fi)
MY (1) MY106161A (fi)
NL (1) NL990008I2 (fi)
NZ (1) NZ237434A (fi)
PL (1) PL170321B1 (fi)
PT (1) PT97034B (fi)
SA (1) SA92120358B1 (fi)
TW (1) TW213486B (fi)

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US5672683A (en) * 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
CA2123307A1 (en) * 1991-11-26 1993-06-10 Phillip M. Friden Process for the preparation of transferrin receptor specific antibody-neuro-pharmaceutical or diagnostic agent conjugates
US6024957A (en) * 1993-06-02 2000-02-15 Research Corporation Technologies, Inc. Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same
US6106834A (en) 1993-06-02 2000-08-22 Research Corporation Technologies, Inc. Use of anti-CD45 leukocyte antigen antibodies for immunomodulation
US6015555A (en) * 1995-05-19 2000-01-18 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
US7033589B1 (en) 1997-02-20 2006-04-25 Biogen Idec Ma Inc. γ-1 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
US6893636B2 (en) * 1997-02-20 2005-05-17 Biogen Idec Ma Inc. Gamma-1 and gamma-3 anti-human CD23 monoclonal antibodies and use thereof as therapeutics
CA2298491C (en) 1997-07-25 2009-10-06 Nichia Chemical Industries, Ltd. Nitride semiconductor device
AUPP221098A0 (en) * 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
JP3973360B2 (ja) * 1998-07-27 2007-09-12 ノバルティス アクチエンゲゼルシャフト 関節リウマチまたは皮膚疾患の処置に使用するためのｃｄ２５結合分子
WO2000025816A1 (en) * 1998-10-30 2000-05-11 The University Of Miami Treatment of hepatitis c by administration of anti-il-2 receptor monoclonal antibody and an antiviral compound
US6406695B1 (en) 1998-10-30 2002-06-18 University Of Miami Treatment of hepatitis C by administration of anti-IL-2 receptor monoclonal antibody
GB9825632D0 (en) 1998-11-23 1999-01-13 Novartis Ag Organic compounds
FR2793691B1 (fr) * 1999-05-21 2003-10-03 Hippocampe Utilisation d'anticorps reconnaissant le recepteur de l'interleukine-2 dans la prevention et/ou le traitement des infections par les virus du sida
GB0007911D0 (en) * 2000-03-30 2000-05-17 Novartis Ag Organic compounds
ES2314067T3 (es) 2001-04-06 2009-03-16 University Of Bristol Uso de moleculas de enlace cd 25 en pacientes resistentes a los esteroides.
US7217798B2 (en) * 2003-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of Fc-fusion protein serum half-lives by mutagenesis
US7365168B2 (en) * 2002-10-15 2008-04-29 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7361740B2 (en) * 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
JP4033390B2 (ja) * 2002-10-30 2008-01-16 独立行政法人科学技術振興機構 不死化ナチュラルキラー細胞株
EP1578397B1 (en) * 2002-11-15 2012-12-26 Genmab A/S Human monoclonal antibodies against cd25
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
CU23297A1 (es) * 2004-11-16 2008-07-24 Ct De Inmunologa A Molecular Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer
GB0507696D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds
PT2270050E (pt) 2005-12-30 2013-09-12 Merck Patent Gmbh Anticorpos anti-cd19 com imunogenicidade reduzida
CA2718191C (en) 2008-03-13 2018-05-15 Biotest Ag Agent for treating disease
AU2009224690B2 (en) 2008-03-13 2014-10-09 Biotest Ag Agent for treating disease
KR20100135257A (ko) 2008-03-13 2010-12-24 바이오테스트 아게 질병 치료제
PL2493922T3 (pl) 2009-10-26 2017-07-31 F.Hoffmann-La Roche Ag Sposób wytwarzania glikozylowanych immunoglobulin
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
US9580501B2 (en) 2011-12-16 2017-02-28 Synthon Biopharmaceuticals B.V. Anti-TNF alpha monoclonal secretory IgA antibodies and methods for treating inflammatory diseases
PL2766048T3 (pl) 2012-10-12 2015-05-29 Medimmune Ltd Pirolobenzodiazepiny i ich koniugaty
US20160031887A1 (en) 2013-03-13 2016-02-04 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP3193940A1 (en) 2014-09-10 2017-07-26 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
KR20170101895A (ko) 2014-11-25 2017-09-06 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항체 접합체
US9993452B2 (en) 2014-12-05 2018-06-12 Vireo Systems, Inc. Compositions and methods for treatment of inflammation
US20170157215A1 (en) 2015-12-04 2017-06-08 Jomoco, Corp. Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates
CN109862919A (zh) 2016-10-11 2019-06-07 免疫医疗有限公司 抗体-药物缀合物联合免疫介导的治疗剂
CA3057744A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-cd25 antibody-drug conjugate
CN113286616A (zh) 2018-05-23 2021-08-20 Adc治疗有限公司 分子佐剂
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CA3135992C (en) * 2019-06-10 2024-02-13 Shandong Boan Biotechnology Co., Ltd. Anti-cd25 antibody and application thereof
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Also Published As

Publication number Publication date
EP0449769A1 (en) 1991-10-02
DK0449769T3 (da) 1994-02-21
HUT60768A (en) 1992-10-28
ATE98655T1 (de) 1994-01-15
DE19975033I2 (de) 2007-01-04
JP2585475B2 (ja) 1997-02-26
FI911275A0 (fi) 1991-03-14
IL97545A0 (en) 1992-06-21
MY106161A (en) 1995-03-31
DE69100768D1 (de) 1994-01-27
HU211885A9 (en) 1995-12-28
ES2061216T3 (es) 1994-12-01
FI19991788A (fi) 1999-08-23
IE910867A1 (en) 1991-09-25
NL990008I2 (nl) 1999-10-01
NL990008I1 (nl) 1999-06-01
HU910761D0 (en) 1991-09-30
HK53797A (en) 1997-05-02
FI104047B (fi) 1999-11-15
DE69100768T2 (de) 1994-05-11
IE65062B1 (en) 1995-10-04
PL170321B1 (pl) 1996-11-29
IL97545A (en) 2000-06-29
JPH04316600A (ja) 1992-11-06
SA92120358B1 (ar) 2004-01-25
CA2038279C (en) 1999-03-09
AU635401B2 (en) 1993-03-18
PT97034B (pt) 1998-07-31
CY1977A (en) 1997-09-05
FI981799A0 (fi) 1998-08-21
LU90383I2 (fr) 1999-06-07
EP0449769B1 (en) 1993-12-15
TW213486B (fi) 1993-09-21
PT97034A (pt) 1991-10-31
FI103131B (fi) 1999-04-30
CA2038279A1 (en) 1991-09-17
FI103131B1 (fi) 1999-04-30
AU7290991A (en) 1991-09-19
PL289436A1 (en) 1992-02-24
FI911275A (fi) 1991-09-17
NZ237434A (en) 1992-08-26
US6383487B1 (en) 2002-05-07
FI104047B1 (fi) 1999-11-15
US6521230B1 (en) 2003-02-18

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Owner name: NOVARTIS AG