FI97541B - Förfarande för framställning av nya terapeutiskt användbara N-difenylalkylalkoxisubstituerade 3-piperidinkarboxylsyraderivat - Google Patents
Förfarande för framställning av nya terapeutiskt användbara N-difenylalkylalkoxisubstituerade 3-piperidinkarboxylsyraderivat Download PDFInfo
- Publication number
- FI97541B FI97541B FI922268A FI922268A FI97541B FI 97541 B FI97541 B FI 97541B FI 922268 A FI922268 A FI 922268A FI 922268 A FI922268 A FI 922268A FI 97541 B FI97541 B FI 97541B
- Authority
- FI
- Finland
- Prior art keywords
- added
- mixture
- ethyl
- stirred
- solution
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Indole Compounds (AREA)
Claims (3)
1. Förfarande för framställning av nya N-difenylal-kylalkoxisubstituerade 3-piperidinkarboxylsyror med for-5 mein I och estrar, geometriska och optiska isomerer samt farmaceutiskt godtagbara salter därav,
10 Y- (CH2) s-0- (CH2) ----r4 (I) O^R6 i vilken formel Y är
15 R\ R\ CH-CH0- eller C=CH- 2^ 2 2^ RZ RZ varvid R1 och R2 betecknar fenyl, som kan vara substituerad 20 med halogen, tri f luormetyl, C^-alkyl eller Cj.g-alkoxi; s är 1, 2 eller 3; r är 2, 3 eller 4; R4 och R5 betecknar väte eller de bildar tillsammans en bindning; och R6 är OH eller C^.g-alkoxi, kännetecknat därav, att a) en förening med formeln 25 Vi Y-(CH2)s-0-(CH2)r-Z (II) • «· • * • · * där Y, r och s betecknar samma som ovan och z är en lämp- • t i '·' ‘ lig avgäende grupp, säsom halogen, p-toluensulfonat eller 30 mesylat, omsätts med en förening med formeln • t 1 4 · « • » * :T: f^YR5 HN\^T\.r4 (III) 35 <A« tl 97541 53 där R4, R5 och R6 betecknar sanuna som ovan, eller b) en förening med formeln , rv*’ '^c-CH-(CH2>S-°-|CH2»r-H'^KR4 (IV) R2 <A« väri R1, R2, R4, R5, R6, r och s betecknar samma som ovan, 10 hydrogeneras, varvid erhälls en förening med formeln I, där R4 och R5 betecknar väte och Y är R\ CH-CH--2 ^ Δ
15 RZ
2. Förfarande enligt patentkravet 1, k ä n n e -t e c k n a t därav, att man framställer ( R)-N-(2-(3,3-difenyl-l-propyloxi)etyl)-3-piperidinkar-20 boxylsyra; N-(2-(3,3-difenyl-l-propyloxi)etyl)-1,2,5,6-tetrahydro-3-pyridinkarboxylsyra; (R) -N- ( 2- ( 3-difenyl- (3- ( 3-trif luormetyl) f enyl) - 1-propyl- oxi)etyl)-3-piperidinkarboxylsyra; 25 (R)-N-( 2-(3,3-bis(4-klorfenyl )-l-propyloxi )etyl)-3-piperi- *; *' dinkarboxylsyra; * · *· '· (R)-N-(2-(3-(3-metoxifenyl)-3-(2-metylfenyl)-1-propyloxi)- V'. etyl)-3-piperidinkarboxylsyra; * I · V (R)-N-( 3-(3,3-bis( 2-metylfenyl )-2-propen-l-yloxi )-l-pro- 30 pyi)-3-piperidinkarboxylsyra; : ;‘i eller ett farmaceutiskt godtagbart sait av dessa. « »♦ • t « i « · • · #
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK588189A DK588189D0 (da) | 1989-11-22 | 1989-11-22 | Nye heterocykliske carboxylsyrer |
DK588189 | 1989-11-22 | ||
DK9000302 | 1990-11-22 | ||
PCT/DK1990/000302 WO1991007389A1 (en) | 1989-11-22 | 1990-11-22 | N-substituted azaheterocyclic carboxylic acids and a pharmaceutical composition |
Publications (4)
Publication Number | Publication Date |
---|---|
FI922268A FI922268A (sv) | 1992-05-19 |
FI922268A0 FI922268A0 (sv) | 1992-05-19 |
FI97541B true FI97541B (sv) | 1996-09-30 |
FI97541C FI97541C (sv) | 1997-01-10 |
Family
ID=8145900
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI922268A FI97541C (sv) | 1989-11-22 | 1992-05-19 | Förfarande för framställning av nya terapeutiskt användbara N-difenylalkylalkoxisubstituerade 3-piperidinkarboxylsyraderivat |
Country Status (16)
Country | Link |
---|---|
US (1) | US5198451A (sv) |
EP (1) | EP0502031B1 (sv) |
JP (1) | JPH05503083A (sv) |
AT (1) | ATE157086T1 (sv) |
AU (1) | AU660919B2 (sv) |
CA (1) | CA2073189C (sv) |
DE (1) | DE69031312T2 (sv) |
DK (2) | DK588189D0 (sv) |
FI (1) | FI97541C (sv) |
IE (1) | IE904155A1 (sv) |
IL (2) | IL96370A (sv) |
NO (1) | NO177853C (sv) |
NZ (1) | NZ236155A (sv) |
PT (1) | PT95970B (sv) |
WO (1) | WO1991007389A1 (sv) |
ZA (1) | ZA909305B (sv) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK74693D0 (da) * | 1993-06-23 | 1993-06-23 | Novo Nordisk As | Novel heterocyclic chemistry |
US5962449A (en) | 1995-04-07 | 1999-10-05 | Novo Nordisk A/S | Tricyclic compounds in treating hyperalgesic conditions and NIDDM |
EP0912091B1 (en) * | 1996-05-24 | 2007-12-19 | Smithkline Beecham Corporation | Use of gaba uptake inhibitors as anti-tussive agents |
DE10204496A1 (de) * | 2002-02-04 | 2003-08-21 | Msa Auer Gmbh | Vorrichtung zur Dosierung gas- und/oder dampfförmiger Stoffe |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4383999A (en) * | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
DK704488D0 (da) * | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
DK288385D0 (da) * | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
FI864246A (fi) * | 1985-11-08 | 1987-05-09 | Warner Lambert Co | N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat. |
US4910312A (en) * | 1985-11-08 | 1990-03-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
US4772615A (en) * | 1985-11-08 | 1988-09-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
IL81179A (en) * | 1986-01-07 | 1992-02-16 | Novo Nordisk As | N-phenylbutenyl substituted azaheterocyclic carboxylic acids,their preparation and pharmaceutical compositions comprising them |
US5006560A (en) * | 1989-12-20 | 1991-04-09 | Schering Corporation | Use of GABA-B selective agonists as anti-tussive agents |
-
1989
- 1989-11-22 DK DK588189A patent/DK588189D0/da not_active Application Discontinuation
-
1990
- 1990-11-16 IL IL9637090A patent/IL96370A/en not_active IP Right Cessation
- 1990-11-16 IL IL69370A patent/IL96370A0/xx unknown
- 1990-11-19 IE IE415590A patent/IE904155A1/en unknown
- 1990-11-20 ZA ZA909305A patent/ZA909305B/xx unknown
- 1990-11-20 US US07/616,165 patent/US5198451A/en not_active Expired - Fee Related
- 1990-11-20 NZ NZ236155A patent/NZ236155A/xx unknown
- 1990-11-22 PT PT95970A patent/PT95970B/pt active IP Right Grant
- 1990-11-22 WO PCT/DK1990/000302 patent/WO1991007389A1/en active IP Right Grant
- 1990-11-22 DE DE69031312T patent/DE69031312T2/de not_active Expired - Fee Related
- 1990-11-22 AT AT90917178T patent/ATE157086T1/de active
- 1990-11-22 AU AU67464/90A patent/AU660919B2/en not_active Ceased
- 1990-11-22 JP JP3500073A patent/JPH05503083A/ja active Pending
- 1990-11-22 EP EP90917178A patent/EP0502031B1/en not_active Expired - Lifetime
- 1990-11-22 DK DK90917178.7T patent/DK0502031T3/da active
- 1990-11-22 CA CA002073189A patent/CA2073189C/en not_active Expired - Fee Related
-
1992
- 1992-05-11 NO NO921852A patent/NO177853C/no unknown
- 1992-05-19 FI FI922268A patent/FI97541C/sv active
Also Published As
Publication number | Publication date |
---|---|
IL96370A0 (en) | 1991-08-16 |
NO921852D0 (no) | 1992-05-11 |
IE904155A1 (en) | 1991-05-22 |
FI97541C (sv) | 1997-01-10 |
NO177853C (no) | 1995-12-06 |
NO921852L (no) | 1992-05-11 |
CA2073189A1 (en) | 1991-05-23 |
FI922268A (sv) | 1992-05-19 |
PT95970A (pt) | 1991-09-13 |
EP0502031B1 (en) | 1997-08-20 |
DK588189D0 (da) | 1989-11-22 |
EP0502031A1 (en) | 1992-09-09 |
CA2073189C (en) | 1998-04-07 |
US5198451A (en) | 1993-03-30 |
FI922268A0 (sv) | 1992-05-19 |
IL96370A (en) | 1995-01-24 |
ATE157086T1 (de) | 1997-09-15 |
JPH05503083A (ja) | 1993-05-27 |
DK0502031T3 (da) | 1998-03-30 |
AU660919B2 (en) | 1995-07-13 |
DE69031312T2 (de) | 1998-02-26 |
NO177853B (no) | 1995-08-28 |
ZA909305B (en) | 1991-09-25 |
WO1991007389A1 (en) | 1991-05-30 |
PT95970B (pt) | 1998-01-30 |
NZ236155A (en) | 1993-04-28 |
DE69031312D1 (de) | 1997-09-25 |
AU6746490A (en) | 1991-06-13 |
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Date | Code | Title | Description |
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BB | Publication of examined application |