FI971413A0 - Puriini- ja guaniiniyhdisteet PNP:n estäjinä - Google Patents

Puriini- ja guaniiniyhdisteet PNP:n estäjinä

Info

Publication number
FI971413A0
FI971413A0 FI971413A FI971413A FI971413A0 FI 971413 A0 FI971413 A0 FI 971413A0 FI 971413 A FI971413 A FI 971413A FI 971413 A FI971413 A FI 971413A FI 971413 A0 FI971413 A0 FI 971413A0
Authority
FI
Finland
Prior art keywords
purine
pnp inhibitors
guanine compounds
guanine
compounds
Prior art date
Application number
FI971413A
Other languages
English (en)
Swedish (sv)
Other versions
FI971413A (fi
Inventor
Steven Collin Beasley
Alan Findlay Haughan
John Montana
Robert John Watson
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9420127A external-priority patent/GB9420127D0/en
Priority claimed from GB9420093A external-priority patent/GB9420093D0/en
Priority claimed from GB9420045A external-priority patent/GB9420045D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Publication of FI971413A publication Critical patent/FI971413A/fi
Publication of FI971413A0 publication Critical patent/FI971413A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI971413A 1994-10-05 1997-04-04 Puriini- ja guaniiniyhdisteet PNP:n estäjinä FI971413A0 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9420127A GB9420127D0 (en) 1994-10-05 1994-10-05 Compounds
GB9420093A GB9420093D0 (en) 1994-10-05 1994-10-05 Compounds
GB9420045A GB9420045D0 (en) 1994-10-05 1994-10-05 Compounds
PCT/GB1995/002363 WO1996011200A1 (en) 1994-10-05 1995-10-05 Purine and guanine compounds as inhibitors of pnp

Publications (2)

Publication Number Publication Date
FI971413A FI971413A (fi) 1997-04-04
FI971413A0 true FI971413A0 (fi) 1997-04-04

Family

ID=27267411

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971413A FI971413A0 (fi) 1994-10-05 1997-04-04 Puriini- ja guaniiniyhdisteet PNP:n estäjinä

Country Status (14)

Country Link
US (1) US5736549A (fi)
EP (1) EP0784624A1 (fi)
JP (1) JPH10507171A (fi)
CN (1) CN1045088C (fi)
AU (1) AU695032B2 (fi)
BR (1) BR9509236A (fi)
CA (1) CA2201773A1 (fi)
CZ (1) CZ99797A3 (fi)
FI (1) FI971413A0 (fi)
HU (1) HUT77436A (fi)
MX (1) MX9702488A (fi)
NO (1) NO971538L (fi)
PL (1) PL319485A1 (fi)
WO (1) WO1996011200A1 (fi)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869953A1 (en) * 1994-10-22 1998-10-14 Chong Kun Dang Corp Nucleoside derivatives and process for preparing thereof
AU2877102A (en) * 2000-11-02 2002-05-15 Sloan Kettering Inst Cancer Small molecule compositions for binding to hsp90
AU2003233667A1 (en) * 2002-05-23 2003-12-12 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
RU2330042C2 (ru) * 2002-08-21 2008-07-27 Альберт Эйнштейн Колледж Оф Медсин Оф Йешива Юниверсити Ингибиторы нуклеозидфосфорилаз и нуклеозидаз
WO2005053695A1 (ja) * 2003-12-04 2005-06-16 Eisai Co., Ltd. 多発性硬化症予防剤または治療剤
US8012964B2 (en) * 2004-03-26 2011-09-06 Dainippon Sumitomo Pharma Co., Ltd. 9-substituted 8-oxoadenine compound
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
TW200801003A (en) * 2005-09-16 2008-01-01 Astrazeneca Ab Novel compounds
JPWO2007034817A1 (ja) * 2005-09-22 2009-03-26 大日本住友製薬株式会社 新規アデニン化合物
US20080269240A1 (en) * 2005-09-22 2008-10-30 Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan Novel Adenine Compound
TW200745114A (en) * 2005-09-22 2007-12-16 Astrazeneca Ab Novel compounds
WO2007034881A1 (ja) * 2005-09-22 2007-03-29 Dainippon Sumitomo Pharma Co., Ltd. 新規アデニン化合物
US20090099216A1 (en) * 2005-09-22 2009-04-16 Astrazeneca Aktiebolag A Corporation Of Sweden Novel adenine compound
JP5304981B2 (ja) 2005-12-26 2013-10-02 日産化学工業株式会社 １，３−ビス（置換フェニル）−３−ヒドロキシプロパン−１−オンおよび２−プロペン−１−オン化合物およびその塩
US8138172B2 (en) * 2006-07-05 2012-03-20 Astrazeneca Ab 8-oxoadenine derivatives acting as modulators of TLR7
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
PT2132209E (pt) * 2007-03-19 2014-04-15 Astrazeneca Ab Compostos de 8-oxo-adenina substituídos na posição 9, como moduladores do recetor de tipo ¿toll¿ (tlr7)
JP5329444B2 (ja) * 2007-03-19 2013-10-30 アストラゼネカ・アクチエボラーグ Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
EP2138497A4 (en) 2007-03-20 2012-01-04 Dainippon Sumitomo Pharma Co NEW ADENINE CONNECTION
TW200902018A (en) * 2007-03-20 2009-01-16 Dainippon Sumitomo Pharma Co Novel adenine compound
PL2155743T3 (pl) 2007-05-08 2013-01-31 Astrazeneca Ab Imidazochinoliny o właściwościach immunomodulacyjnych
PE20091236A1 (es) 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
UA104579C2 (uk) 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
PE20091156A1 (es) 2007-12-17 2009-09-03 Astrazeneca Ab Sales de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo
KR20100125245A (ko) 2008-01-17 2010-11-30 다이닛본 스미토모 세이야꾸 가부시끼가이샤 아데닌 화합물의 제조 방법
JPWO2009091031A1 (ja) * 2008-01-17 2011-05-26 大日本住友製薬株式会社 アデニン化合物の製造方法
WO2010133885A1 (en) 2009-05-21 2010-11-25 Astrazeneca Ab Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
GB0908772D0 (en) * 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
EP2507237A1 (en) * 2009-12-03 2012-10-10 Dainippon Sumitomo Pharma Co., Ltd. Imidazoquinolines which act via toll - like receptors (tlr)
EP2651937B8 (en) 2010-12-16 2016-07-13 Sumitomo Dainippon Pharma Co., Ltd. Imidazo[4,5-c]quinolin-1-yl derivative useful in therapy
WO2012080730A1 (en) 2010-12-17 2012-06-21 Astrazeneca Ab Purine derivatives
KR101708761B1 (ko) 2012-04-13 2017-02-21 주식회사 머쉬메드 퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물
AU2013261267B2 (en) 2012-05-18 2017-06-29 Sumitomo Pharma Co., Ltd. Carboxylic acid compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241063A (en) * 1979-08-06 1980-12-23 Bristol-Myers Company Purine derivatives and their use as bronchodilators
FI802401A (fi) * 1979-08-06 1981-02-07 Bristol Myers Co Bronkutvidgande purin
US4748177A (en) * 1984-03-26 1988-05-31 Warner-Lambert Company Guanine derivatives
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
IL76546A (en) * 1984-10-12 1988-12-30 Warner Lambert Co 9-(heteroarylalkyl)-6-purine(thi)one derivatives,their preparation and pharmaceutical compositions containing them
EP0193454A1 (en) * 1985-02-25 1986-09-03 Merck & Co. Inc. 8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them
IE60433B1 (en) * 1986-08-26 1994-07-13 Warner Lambert Co Novel 9-deazaguanines
EP0302644B1 (en) * 1987-08-01 1997-01-29 Beecham Group Plc Purine compounds and their preparation
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
US4985434A (en) * 1989-10-31 1991-01-15 Biocryst, Inc. 7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
AU654264B2 (en) * 1989-10-31 1994-11-03 Biocryst Pharmaceuticals, Inc. Inhibitors of purine nucleoside phosphorylase
NL9300058A (nl) * 1992-06-18 1994-01-17 Stichting Rega V Z W 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan.
US5314893A (en) * 1993-01-25 1994-05-24 Bristol-Myers Squibb Co. Antiviral tetrahydropyrans
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents

Also Published As

Publication number Publication date
US5736549A (en) 1998-04-07
BR9509236A (pt) 1997-10-21
CN1045088C (zh) 1999-09-15
NO971538D0 (no) 1997-04-04
PL319485A1 (en) 1997-08-04
CA2201773A1 (en) 1996-04-18
CZ99797A3 (en) 1997-09-17
EP0784624A1 (en) 1997-07-23
WO1996011200A1 (en) 1996-04-18
FI971413A (fi) 1997-04-04
AU3612895A (en) 1996-05-02
AU695032B2 (en) 1998-08-06
JPH10507171A (ja) 1998-07-14
MX9702488A (es) 1998-04-30
CN1160402A (zh) 1997-09-24
NO971538L (no) 1997-06-04
HUT77436A (hu) 1998-04-28

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