FI963222A - 6-substituoitu 4-amino-mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta - Google Patents

6-substituoitu 4-amino-mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta Download PDF

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Publication number
FI963222A
FI963222A FI963222A FI963222A FI963222A FI 963222 A FI963222 A FI 963222A FI 963222 A FI963222 A FI 963222A FI 963222 A FI963222 A FI 963222A FI 963222 A FI963222 A FI 963222A
Authority
FI
Finland
Prior art keywords
mycophenolic acid
derivatives
amino
substituted
immunosuppressive activity
Prior art date
Application number
FI963222A
Other languages
English (en)
Swedish (sv)
Other versions
FI963222A0 (fi
Inventor
Dean R Artis
Todd R Elworthy
Ronald C Hawley
David G Loughhead
Jr David J Morgans
Peter H Nelson
Jr John W Patterson
Eric B Sjogren
David B Smith
Ann Marie Waltos
Robert J Weikert
Alicia C Garcia
Mario F Zertuche
Fidencio F Andrade
Maria T L Hernandez
Francisco X T Murra
Teresa A T Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of FI963222A0 publication Critical patent/FI963222A0/fi
Publication of FI963222A publication Critical patent/FI963222A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI963222A 1994-02-18 1996-08-16 6-substituoitu 4-amino-mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta FI963222A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/198,741 US5525602A (en) 1994-02-18 1994-02-18 Method of using 4-amino 6-substituted mycophenolic acid and derivatives
PCT/US1995/001783 WO1995022534A1 (en) 1994-02-18 1995-02-16 4-amino 6-substituted mycophenolic acid and derivatives with immunosuppressive activity

Publications (2)

Publication Number Publication Date
FI963222A0 FI963222A0 (fi) 1996-08-16
FI963222A true FI963222A (fi) 1996-10-18

Family

ID=22734615

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963222A FI963222A (fi) 1994-02-18 1996-08-16 6-substituoitu 4-amino-mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta

Country Status (19)

Country Link
US (2) US5525602A (fi)
EP (1) EP0745071B1 (fi)
JP (1) JPH09509170A (fi)
CN (1) CN1141632A (fi)
AT (1) ATE210126T1 (fi)
AU (1) AU1747295A (fi)
BR (1) BR9506836A (fi)
CA (1) CA2183532A1 (fi)
CO (1) CO4340733A1 (fi)
DE (1) DE69524388T2 (fi)
DK (1) DK0745071T3 (fi)
ES (1) ES2169124T3 (fi)
FI (1) FI963222A (fi)
IL (1) IL112668A (fi)
MX (1) MX9603477A (fi)
PT (1) PT745071E (fi)
TW (1) TW427986B (fi)
WO (1) WO1995022534A1 (fi)
ZA (1) ZA951300B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19541578C2 (de) * 1995-11-08 1997-08-21 Koenig & Bauer Albert Ag Wendestange
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
WO2017210262A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5542995B2 (fi) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5529994B2 (fi) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid

Also Published As

Publication number Publication date
AU1747295A (en) 1995-09-04
ES2169124T3 (es) 2002-07-01
ATE210126T1 (de) 2001-12-15
CN1141632A (zh) 1997-01-29
TW427986B (en) 2001-04-01
MX9603477A (es) 1997-12-31
JPH09509170A (ja) 1997-09-16
ZA951300B (en) 1996-08-16
US5554612A (en) 1996-09-10
DK0745071T3 (da) 2002-04-02
CO4340733A1 (es) 1996-07-30
US5525602A (en) 1996-06-11
PT745071E (pt) 2002-04-29
DE69524388D1 (de) 2002-01-17
WO1995022534A1 (en) 1995-08-24
IL112668A (en) 1999-08-17
IL112668A0 (en) 1995-05-26
CA2183532A1 (en) 1995-08-24
EP0745071A1 (en) 1996-12-04
EP0745071B1 (en) 2001-12-05
DE69524388T2 (de) 2002-08-14
FI963222A0 (fi) 1996-08-16
BR9506836A (pt) 1997-10-14

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