FI961356A0 - Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseen - Google Patents

Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseen

Info

Publication number
FI961356A0
FI961356A0 FI961356A FI961356A FI961356A0 FI 961356 A0 FI961356 A0 FI 961356A0 FI 961356 A FI961356 A FI 961356A FI 961356 A FI961356 A FI 961356A FI 961356 A0 FI961356 A0 FI 961356A0
Authority
FI
Finland
Prior art keywords
preparation
verpamil
analogs
cir
give
Prior art date
Application number
FI961356A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI961356A (fi
Inventor
Raymond Mccague
Shouming Wang
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Publication of FI961356A publication Critical patent/FI961356A/fi
Publication of FI961356A0 publication Critical patent/FI961356A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI961356A 1993-09-27 1996-03-25 Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseen FI961356A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939319918A GB9319918D0 (en) 1993-09-27 1993-09-27 Chiral compounds and their preparation
PCT/GB1994/002091 WO1995009150A1 (en) 1993-09-27 1994-09-26 Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues

Publications (2)

Publication Number Publication Date
FI961356A FI961356A (fi) 1996-03-25
FI961356A0 true FI961356A0 (fi) 1996-03-25

Family

ID=10742593

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961356A FI961356A0 (fi) 1993-09-27 1996-03-25 Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseen

Country Status (13)

Country Link
EP (1) EP0721448B1 (no)
JP (1) JPH09502995A (no)
CN (1) CN1038838C (no)
AT (1) ATE163920T1 (no)
AU (1) AU676773B2 (no)
CA (1) CA2171431A1 (no)
DE (1) DE69409001T2 (no)
ES (1) ES2113126T3 (no)
FI (1) FI961356A0 (no)
GB (1) GB9319918D0 (no)
HK (1) HK1007657A1 (no)
NO (1) NO305594B1 (no)
WO (1) WO1995009150A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
US5892093A (en) * 1996-02-08 1999-04-06 Darwin Discovery Limited Resolution
AU705865B2 (en) * 1996-02-08 1999-06-03 Darwin Discovery Limited Resolution of 4-cyano-4-(3,4-dimethoxyphenyl) -5-methylhexanoic acid
GB9616549D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
GB9616504D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
AU3778497A (en) * 1996-08-06 1998-02-25 Darwin Discovery Limited Therapeutic utilities of verapamil enantiomers
ITMI20071160A1 (it) * 2007-06-07 2008-12-08 Cosma S P A Procedimento di risoluzione del verapamil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2059923C3 (de) * 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
CA2032872A1 (en) * 1989-12-21 1991-06-22 Philippe R. Bovy W-amino-.alpha.-phenylalkanonitrile derivatives
DE4203547A1 (de) * 1992-02-07 1993-08-12 Knoll Ag Verfahren zur racemattrennung von verapamil

Also Published As

Publication number Publication date
CA2171431A1 (en) 1995-04-06
NO961224D0 (no) 1996-03-26
GB9319918D0 (en) 1993-11-10
AU676773B2 (en) 1997-03-20
AU7702594A (en) 1995-04-18
DE69409001D1 (de) 1998-04-16
WO1995009150A1 (en) 1995-04-06
DE69409001T2 (de) 1998-07-02
ES2113126T3 (es) 1998-04-16
HK1007657A1 (en) 1999-04-16
FI961356A (fi) 1996-03-25
NO305594B1 (no) 1999-06-28
CN1131941A (zh) 1996-09-25
EP0721448A1 (en) 1996-07-17
NO961224L (no) 1996-03-26
EP0721448B1 (en) 1998-03-11
JPH09502995A (ja) 1997-03-25
CN1038838C (zh) 1998-06-24
ATE163920T1 (de) 1998-03-15

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