FI960165A - Säädetty apoptoosi - Google Patents

Säädetty apoptoosi Download PDF

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Publication number
FI960165A
FI960165A FI960165A FI960165A FI960165A FI 960165 A FI960165 A FI 960165A FI 960165 A FI960165 A FI 960165A FI 960165 A FI960165 A FI 960165A FI 960165 A FI960165 A FI 960165A
Authority
FI
Finland
Prior art keywords
regulated apoptosis
apoptosis
regulated
Prior art date
Application number
FI960165A
Other languages
English (en)
Swedish (sv)
Other versions
FI960165A0 (fi
Inventor
Gerald R Crabtree
Stuart L Schreiber
David M Spencer
Thomas J Wandless
Peter Belshaw
Original Assignee
Univ Leland Stanford Junior
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1994/001617 external-priority patent/WO1994018317A1/en
Application filed by Univ Leland Stanford Junior, Harvard College filed Critical Univ Leland Stanford Junior
Publication of FI960165A0 publication Critical patent/FI960165A0/fi
Publication of FI960165A publication Critical patent/FI960165A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
FI960165A 1993-07-16 1996-01-15 Säädetty apoptoosi FI960165A (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9349993A 1993-07-16 1993-07-16
US17914394A 1994-01-07 1994-01-07
PCT/US1994/001617 WO1994018317A1 (en) 1993-02-12 1994-02-14 Regulated transcription of targeted genes and other biological events
PCT/US1994/008008 WO1995002684A1 (en) 1993-07-16 1994-07-18 Regulated apoptosis

Publications (2)

Publication Number Publication Date
FI960165A0 FI960165A0 (fi) 1996-01-15
FI960165A true FI960165A (fi) 1996-01-26

Family

ID=27377531

Family Applications (1)

Application Number Title Priority Date Filing Date
FI960165A FI960165A (fi) 1993-07-16 1996-01-15 Säädetty apoptoosi

Country Status (6)

Country Link
JP (1) JPH09503645A (fi)
AU (1) AU696991B2 (fi)
CA (1) CA2167282A1 (fi)
FI (1) FI960165A (fi)
HU (1) HUT73100A (fi)
WO (1) WO1995002684A1 (fi)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0776327B1 (en) * 1994-08-18 2005-07-06 Ariad Gene Therapeutics, Inc. New multimerizing agents
WO1996012796A1 (en) * 1994-10-25 1996-05-02 The Board Of Trustees Of The Leland Stanford Junior University Conditional transformation of genetically engineered cells
WO1998039418A1 (en) * 1997-03-07 1998-09-11 Ariad Gene Therapeutics, Inc. New applications of gene therapy technology
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
WO1996041865A1 (en) * 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Rapamcycin-based regulation of biological events
CA2252886C (en) * 1996-04-26 2008-02-12 Massachusetts Institute Of Technology Three-hybrid screening assay
JPH10234372A (ja) * 1997-02-27 1998-09-08 Boehringer Mannheim Corp キメラ受容体を有する細胞とその作成方法、並びに その利用
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US5945441A (en) * 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
WO1999000491A1 (fr) 1997-06-27 1999-01-07 Ono Pharmaceutical Co., Ltd. Nouvel adn plasmidique contenant de l'adn de gene reporter et utilisation associee
US6982082B1 (en) 1997-08-27 2006-01-03 President And Fellows Of Harvard College Gene therapy by cell specific targeting
US6153383A (en) * 1997-12-09 2000-11-28 Verdine; Gregory L. Synthetic transcriptional modulators and uses thereof
FR2774289B1 (fr) 1998-02-03 2002-05-24 Goemar Lab Sa Medicament pour le traitement des dereglements de l'apoptose
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
AU3454799A (en) * 1998-03-30 1999-10-18 Baylor College Of Medicine Regulated apoptosis using chemically induced dimerization of apoptosis factors
DE69942578D1 (de) 1998-05-22 2010-08-26 Univ R Bifunktionelle moleküle sowie darauf basierende therapien.
EP1085853A1 (en) 1998-06-03 2001-03-28 GPI NIL Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
EA014417B1 (ru) * 1998-09-23 2010-12-30 Займодженетикс, Инк. Экспрессирующий вектор, содержащий полинуклеотид, кодирующий зрелый полипептид zalpha11 рецептора цитокина человека класса i или его функциональные компоненты, культивируемые клетки, содержащие экспрессирующий вектор, способ получения зрелого полипептида zalpha11 или его функциональных компонентов, полипептид, полученный данным способом, антитело, которое связывается с полипептидом, и полинуклеотид, кодирующий полипептид
GB9914650D0 (en) * 1999-06-24 1999-08-25 Angyogene Pharmaceuticals Ltd Chimeric proteins mediating targeted apoptosis
GB9915074D0 (en) * 1999-06-28 1999-08-25 Cortecs Plc Ligand-binding composition
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
EP1229924A4 (en) 1999-11-19 2004-12-15 Univ Leland Stanford Junior TARGETED BIFUNCTIONAL MOLECULES AND THERAPIES THEREFORE
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
MXPA04007402A (es) 2002-02-01 2005-06-17 Ariad Gene Therapeutics Inc Compuestos que contienen fosforo y usos de los mismos.
US7638331B2 (en) 2004-01-02 2009-12-29 The Administration of the Tulane Rducation Fund Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
US7968762B2 (en) 2004-07-13 2011-06-28 Van Andel Research Institute Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF)
US8603751B2 (en) 2006-03-02 2013-12-10 The Uab Research Foundation Mycobacterial disease detection, treatment, and drug discovery
EP2258858A1 (en) 2009-06-05 2010-12-08 Universitätsklinikum Freiburg Transgenic LSD1 animal model for cancer
US10634668B2 (en) 2012-09-13 2020-04-28 Takara Bio Usa, Inc. Modifiable chemical inducers of proximity and methods of using the same
EP3663405A1 (en) 2013-06-11 2020-06-10 Takara Bio USA, Inc. Protein enriched microvesicles and methods of making and using the same
EP3443001A4 (en) 2016-04-11 2020-04-29 Obsidian Therapeutics, Inc. REGULATED BIOCIRCUIT SYSTEMS
US10828330B2 (en) 2017-02-22 2020-11-10 IO Bioscience, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
JPWO2021079656A1 (fi) * 2019-10-24 2021-04-29
CN116179608B (zh) * 2023-01-05 2024-03-01 昆明理工大学 一种dsRNA在免疫缺陷中华蜜蜂模型构建中的应用

Also Published As

Publication number Publication date
JPH09503645A (ja) 1997-04-15
HUT73100A (en) 1996-06-28
WO1995002684A1 (en) 1995-01-26
AU696991B2 (en) 1998-09-24
FI960165A0 (fi) 1996-01-15
CA2167282A1 (en) 1995-01-26
AU7336394A (en) 1995-02-13
HU9600083D0 (en) 1996-03-28

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