FI956203A7 - Lisääntyneen biologisen aktiivisuuden omaava katkaistu keratinosyyttika sivutekijä (KGF) - Google Patents

Lisääntyneen biologisen aktiivisuuden omaava katkaistu keratinosyyttika sivutekijä (KGF) Download PDF

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Publication number
FI956203A7
FI956203A7 FI956203A FI956203A FI956203A7 FI 956203 A7 FI956203 A7 FI 956203A7 FI 956203 A FI956203 A FI 956203A FI 956203 A FI956203 A FI 956203A FI 956203 A7 FI956203 A7 FI 956203A7
Authority
FI
Finland
Prior art keywords
kgf
growth factor
biological activity
keratinocyte growth
increased biological
Prior art date
Application number
FI956203A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI956203A0 (fi
Inventor
Denis J Gospodarowicz
Frank Masiarz
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of FI956203A0 publication Critical patent/FI956203A0/fi
Publication of FI956203A7 publication Critical patent/FI956203A7/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
FI956203A 1993-06-29 1995-12-22 Lisääntyneen biologisen aktiivisuuden omaava katkaistu keratinosyyttika sivutekijä (KGF) FI956203A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8642793A 1993-06-29 1993-06-29
PCT/US1994/004694 WO1995001434A1 (en) 1993-06-29 1994-04-28 A truncated keratinocyte growth factor (kgf) having increased biological activity

Publications (2)

Publication Number Publication Date
FI956203A0 FI956203A0 (fi) 1995-12-22
FI956203A7 true FI956203A7 (fi) 1996-02-07

Family

ID=22198501

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956203A FI956203A7 (fi) 1993-06-29 1995-12-22 Lisääntyneen biologisen aktiivisuuden omaava katkaistu keratinosyyttika sivutekijä (KGF)

Country Status (25)

Country Link
US (7) US5677278A (cs)
EP (2) EP0706563B1 (cs)
JP (4) JP3570516B2 (cs)
KR (1) KR960703433A (cs)
CN (1) CN1129955A (cs)
AT (1) ATE278777T1 (cs)
AU (1) AU681405B2 (cs)
BG (1) BG100236A (cs)
BR (1) BR9407035A (cs)
CA (1) CA2166278A1 (cs)
CZ (1) CZ343795A3 (cs)
DE (2) DE122006000005I2 (cs)
DK (1) DK0706563T3 (cs)
ES (1) ES2227527T3 (cs)
FI (1) FI956203A7 (cs)
FR (1) FR06C0004I2 (cs)
HU (1) HUT73453A (cs)
LU (1) LU91215I2 (cs)
NL (1) NL300217I2 (cs)
NO (1) NO955189D0 (cs)
NZ (1) NZ266622A (cs)
PL (1) PL312257A1 (cs)
PT (1) PT706563E (cs)
SK (1) SK153295A3 (cs)
WO (1) WO1995001434A1 (cs)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026291B1 (en) 1989-01-31 2006-04-11 The United States Of America As Represented By The Department Of Health And Human Services Epithelial cell specific growth factor, keratinocyte growth factor (KGF)
RU2250213C2 (ru) * 1989-01-31 2005-04-20 Джеффри С. РУБИН Выделенный белок фактора роста кератиноцита (kgf), рекомбинантная молекула днк, вектор, способ конструирования клетки-хозяина, способ получения белка, фармацевтическая композиция
US5965530A (en) * 1993-03-26 1999-10-12 Amgen Inc. Therapeutic uses of keratinocyte growth factor
JP3570516B2 (ja) * 1993-06-29 2004-09-29 カイロン コーポレイション 増加した生物学的活性を有する短縮型ケラチノサイト増殖因子（ｋｇｆ）
US7084119B2 (en) * 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
DE122006000019I1 (de) * 1994-10-13 2006-06-29 Amgen Inc Methode zur reinigung von Keratinocyten-Wachstumsfaktoren
US6008328A (en) * 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
AU745815B2 (en) * 1994-10-13 2002-04-11 Biovitrum Ab (Publ) Analogs of keratinocyte growth factor, nucleic acids encoding such analogs, processes of making and methods of using
CZ297329B6 (cs) * 1994-10-13 2006-11-15 Amgen Inc. Analog nativního keratinocytového rustového faktoru kovalentne pripojený k polyethylenglykolu nebo príbuznému vodorozpustnému organickému polymeru, jeho pouzití a in vitro zpusob stimulace produkce nefibroblastových epithelových bunek
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
EP0871730B1 (en) * 1995-10-11 2004-08-18 Chiron Corporation Combination pdgf, kgf, igf and igfbp for wound healing
US6692961B1 (en) 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
DK0935652T3 (da) * 1996-10-15 2004-07-26 Amgen Inc Keratinocyt vækstfaktor-2 produkter
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
EP1473366A1 (en) * 1996-10-15 2004-11-03 Amgen Inc. Keratinocyte growth factor-2 products
AU7970498A (en) * 1997-06-19 1999-01-04 Genetics Institute Inc. Secreted proteins and polynucleotides encoding them
US20080233086A1 (en) * 1997-09-05 2008-09-25 Canbiocin Inc. Expression Vectors for Treating Bacterial Infections
US6238888B1 (en) 1997-12-22 2001-05-29 Human Genone Sciences, Inc. Keratinocyte growth factor-2 formulations
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
AU762519B2 (en) * 1998-02-13 2003-06-26 Human Genome Sciences, Inc. Therapeutic uses of keratinocyte growth factor-2
DE19934510B4 (de) * 1999-07-22 2009-04-16 Vermicon Ag Verfahren zum Nachweis von Mikroorganismen
US6485937B1 (en) 1999-10-15 2002-11-26 The Rockefeller University System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
DE10024334B4 (de) * 2000-05-17 2006-06-01 Medigene Ag Verfahren zum Einbringen von Nukleinsäure in eine Zelle (Transfektion) mittels Calciumphosphat
WO2002042336A2 (en) 2000-11-21 2002-05-30 The Texas A & M University System Fgf-affinity chromatography
US20030186904A1 (en) * 2001-01-08 2003-10-02 Human Genome Sciences, Inc. Keratinocyte growth factor-2
EP1366455B1 (en) 2001-02-19 2008-07-02 MERCK PATENT GmbH Method for identification of t-cell epitopes and use for preparing molecules with reduced immunogenicity
PL374269A1 (en) * 2001-08-21 2005-10-03 Chiron Corporation Kgf polypeptide compositions
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
GB0426394D0 (en) 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
RS53548B1 (en) * 2004-12-15 2015-02-27 Swedish Orphan Biovitrum Ab (Publ) THERAPEUTIC FORMULATIONS OF KERATINocyte GROWTH FACTORS
US20060183712A1 (en) * 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
JP5215865B2 (ja) 2005-11-22 2013-06-19 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド ノロウイルス抗原およびサポウイルス抗原
GB0611405D0 (en) 2006-06-09 2006-07-19 Univ Belfast FKBP-L: A novel inhibitor of angiogenesis
US20080119433A1 (en) * 2006-07-06 2008-05-22 Aaron Thomas Tabor Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
KR101021197B1 (ko) * 2008-04-11 2011-03-11 (주)케어젠 성장인자―미미킹 펩타이드 및 그의 용도
WO2011008904A1 (en) 2009-07-17 2011-01-20 Tabor Aaron T Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
CA2928526A1 (en) 2013-11-01 2015-05-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
CA3227834A1 (en) 2021-08-30 2023-03-09 Dhananjay Sathe Protein compositions for the treatment of inflammatory diseases
KR102691028B1 (ko) * 2021-11-15 2024-08-05 (주)피앤피바이오팜 안정성이 증가된 인간 각질세포 성장인자1 변이체 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2250213C2 (ru) 1989-01-31 2005-04-20 Джеффри С. РУБИН Выделенный белок фактора роста кератиноцита (kgf), рекомбинантная молекула днк, вектор, способ конструирования клетки-хозяина, способ получения белка, фармацевтическая композиция
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5965530A (en) 1993-03-26 1999-10-12 Amgen Inc. Therapeutic uses of keratinocyte growth factor
JP3570516B2 (ja) * 1993-06-29 2004-09-29 カイロン コーポレイション 増加した生物学的活性を有する短縮型ケラチノサイト増殖因子（ｋｇｆ）
JP4422210B2 (ja) 1994-10-13 2010-02-24 アムジエン・インコーポレーテツド ケラチノサイト増殖因子アナログ
CZ297329B6 (cs) 1994-10-13 2006-11-15 Amgen Inc. Analog nativního keratinocytového rustového faktoru kovalentne pripojený k polyethylenglykolu nebo príbuznému vodorozpustnému organickému polymeru, jeho pouzití a in vitro zpusob stimulace produkce nefibroblastových epithelových bunek

Also Published As

Publication number Publication date
US5677278A (en) 1997-10-14
EP0706563B1 (en) 2004-10-06
US5773586A (en) 1998-06-30
DE69434053T2 (de) 2006-02-23
PL312257A1 (en) 1996-04-01
DE69434053D1 (de) 2005-01-20
US5843883A (en) 1998-12-01
US6074848A (en) 2000-06-13
JP4662569B2 (ja) 2011-03-30
EP0706563A1 (en) 1996-04-17
US5863767A (en) 1999-01-26
EP1493812A3 (en) 2006-02-08
JP2004166709A (ja) 2004-06-17
US6677301B1 (en) 2004-01-13
PT706563E (pt) 2005-01-31
CZ343795A3 (en) 1996-07-17
DK0706563T3 (da) 2005-01-31
AU6820894A (en) 1995-01-24
DE122006000005I2 (de) 2006-11-23
AU681405B2 (en) 1997-08-28
HUT73453A (en) 1996-08-28
NZ266622A (en) 1997-10-24
BG100236A (en) 1996-07-31
FI956203A0 (fi) 1995-12-22
HU9503857D0 (en) 1996-02-28
CA2166278A1 (en) 1995-01-12
ATE278777T1 (de) 2004-10-15
FR06C0004I2 (fr) 2006-12-29
WO1995001434A1 (en) 1995-01-12
BR9407035A (pt) 1996-03-12
ES2227527T3 (es) 2005-04-01
SK153295A3 (en) 1996-11-06
NL300217I2 (nl) 2006-05-01
JP2009062396A (ja) 2009-03-26
CN1129955A (zh) 1996-08-28
FR06C0004I1 (cs) 2006-03-10
NL300217I1 (nl) 2006-04-03
JPH09500267A (ja) 1997-01-14
JP2006075173A (ja) 2006-03-23
LU91215I2 (en) 2006-03-27
DE122006000005I1 (de) 2006-08-10
JP3570516B2 (ja) 2004-09-29
NO955189L (no) 1995-12-20
KR960703433A (ko) 1996-08-17
US20090093400A1 (en) 2009-04-09
EP1493812A2 (en) 2005-01-05
NO955189D0 (no) 1995-12-20

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