NL300217I2 - Een afgeknotte keratinocyt groeifactor (KGF) met verhoogde biologische activiteit. - Google Patents

Een afgeknotte keratinocyt groeifactor (KGF) met verhoogde biologische activiteit.

Info

Publication number
NL300217I2
NL300217I2 NL300217C NL300217C NL300217I2 NL 300217 I2 NL300217 I2 NL 300217I2 NL 300217 C NL300217 C NL 300217C NL 300217 C NL300217 C NL 300217C NL 300217 I2 NL300217 I2 NL 300217I2
Authority
NL
Netherlands
Prior art keywords
kgf
keratinocyte growth
growth factor
biological activity
increased biological
Prior art date
Application number
NL300217C
Other languages
English (en)
Other versions
NL300217I1 (nl
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of NL300217I1 publication Critical patent/NL300217I1/nl
Publication of NL300217I2 publication Critical patent/NL300217I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NL300217C 1993-06-29 2006-01-26 Een afgeknotte keratinocyt groeifactor (KGF) met verhoogde biologische activiteit. NL300217I2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8642793A 1993-06-29 1993-06-29
PCT/US1994/004694 WO1995001434A1 (en) 1993-06-29 1994-04-28 A truncated keratinocyte growth factor (kgf) having increased biological activity

Publications (2)

Publication Number Publication Date
NL300217I1 NL300217I1 (nl) 2006-04-03
NL300217I2 true NL300217I2 (nl) 2006-05-01

Family

ID=22198501

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300217C NL300217I2 (nl) 1993-06-29 2006-01-26 Een afgeknotte keratinocyt groeifactor (KGF) met verhoogde biologische activiteit.

Country Status (25)

Country Link
US (7) US5677278A (nl)
EP (2) EP1493812A3 (nl)
JP (4) JP3570516B2 (nl)
KR (1) KR960703433A (nl)
CN (1) CN1129955A (nl)
AT (1) ATE278777T1 (nl)
AU (1) AU681405B2 (nl)
BG (1) BG100236A (nl)
BR (1) BR9407035A (nl)
CA (1) CA2166278A1 (nl)
CZ (1) CZ343795A3 (nl)
DE (2) DE122006000005I2 (nl)
DK (1) DK0706563T3 (nl)
ES (1) ES2227527T3 (nl)
FI (1) FI956203A (nl)
FR (1) FR06C0004I2 (nl)
HU (1) HUT73453A (nl)
LU (1) LU91215I2 (nl)
NL (1) NL300217I2 (nl)
NO (1) NO955189D0 (nl)
NZ (1) NZ266622A (nl)
PL (1) PL312257A1 (nl)
PT (1) PT706563E (nl)
SK (1) SK153295A3 (nl)
WO (1) WO1995001434A1 (nl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026291B1 (en) 1989-01-31 2006-04-11 The United States Of America As Represented By The Department Of Health And Human Services Epithelial cell specific growth factor, keratinocyte growth factor (KGF)
HU218090B (hu) * 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
US5965530A (en) * 1993-03-26 1999-10-12 Amgen Inc. Therapeutic uses of keratinocyte growth factor
EP1493812A3 (en) 1993-06-29 2006-02-08 Chiron Corporation A truncated keratinocyte growth factor (KGF) having increased biological activity
US7084119B2 (en) * 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
AU745815B2 (en) * 1994-10-13 2002-04-11 Biovitrum Ab (Publ) Analogs of keratinocyte growth factor, nucleic acids encoding such analogs, processes of making and methods of using
US6008328A (en) * 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
ES2196082T3 (es) * 1994-10-13 2003-12-16 Amgen Inc Analagos del factor de crecimiento de queratinocitos.
EP0785949B1 (en) * 1994-10-13 2003-05-02 Amgen Inc. Method for purifying keratinocyte growth factors
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
PT1486565E (pt) 1995-10-11 2008-02-28 Novartis Vaccines & Diagnostic Combinação de pdgf, kgf, igf e igfbp para cicatrização de ferimentos
US6692961B1 (en) 1996-10-11 2004-02-17 Invitrogen Corporation Defined systems for epithelial cell culture and use thereof
PT935652E (pt) * 1996-10-15 2004-07-30 Amgen Inc Produtos de factor de crescimento de queratinocitos-2
EP1473366A1 (en) * 1996-10-15 2004-11-03 Amgen Inc. Keratinocyte growth factor-2 products
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US20030144202A1 (en) * 1996-10-15 2003-07-31 Amgen Inc. Uses of keratinocyte growth factor-2
CA2294569A1 (en) * 1997-06-19 1998-12-23 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
US20080233086A1 (en) * 1997-09-05 2008-09-25 Canbiocin Inc. Expression Vectors for Treating Bacterial Infections
WO1999032135A1 (en) * 1997-12-22 1999-07-01 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6599879B1 (en) * 1998-02-13 2003-07-29 Human Genome Sciences, Inc. Therapeutic uses of keratinocyte growth factor-2
DE19934510B4 (de) * 1999-07-22 2009-04-16 Vermicon Ag Verfahren zum Nachweis von Mikroorganismen
AU2039501A (en) 1999-10-15 2001-04-23 Rockefeller University, The System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
DE10024334B4 (de) * 2000-05-17 2006-06-01 Medigene Ag Verfahren zum Einbringen von Nukleinsäure in eine Zelle (Transfektion) mittels Calciumphosphat
US6812221B2 (en) 2000-11-21 2004-11-02 The Texas A&M University System FGF-affinity chromatography
US20030186904A1 (en) * 2001-01-08 2003-10-02 Human Genome Sciences, Inc. Keratinocyte growth factor-2
EP1998266A3 (en) 2001-02-19 2009-02-11 Merck Patent GmbH Method for identification of T-cell epitopes and use for preparing molecules with reduced immunogenicity
AU2002326742B2 (en) 2001-08-21 2007-05-31 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
GB0426394D0 (en) 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
CN101084008B (zh) * 2004-12-15 2013-04-10 比奥维特罗姆股份公开公司 角质形成细胞生长因子的治疗制剂
US20060183712A1 (en) * 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
WO2007081447A2 (en) 2005-11-22 2007-07-19 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
GB0611405D0 (en) * 2006-06-09 2006-07-19 Univ Belfast FKBP-L: A novel inhibitor of angiogenesis
US20080119433A1 (en) * 2006-07-06 2008-05-22 Aaron Thomas Tabor Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
KR101021197B1 (ko) * 2008-04-11 2011-03-11 (주)케어젠 성장인자―미미킹 펩타이드 및 그의 용도
EP4219708A3 (en) 2009-07-17 2023-10-11 Aaron Thomas Tabor Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
JP2016535770A (ja) 2013-11-01 2016-11-17 スフェリウム バイオメッド エス．エル． 治療用及び美容用物質を経皮送達するための封入体
CA3227834A1 (en) 2021-08-30 2023-03-09 Dhananjay Sathe Protein compositions for the treatment of inflammatory diseases
KR20230070596A (ko) * 2021-11-15 2023-05-23 (주)피앤피바이오팜 안정성이 증가된 인간 각질세포 성장인자1 변이체 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218090B (hu) 1989-01-31 2000-05-28 Stuart A. Aaronson Eljárás hámsejtekre specifikus növekedési faktor és az ezt kódoló DNS, az ez ellen termelődött antitestek valamint a növekedési faktort vagy az antitestet tartalmazó gyógyászati készítmények előállítására
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5965530A (en) 1993-03-26 1999-10-12 Amgen Inc. Therapeutic uses of keratinocyte growth factor
EP1493812A3 (en) 1993-06-29 2006-02-08 Chiron Corporation A truncated keratinocyte growth factor (KGF) having increased biological activity
EP0785950B1 (en) 1994-10-13 2003-04-16 Amgen Inc., Keratinocyte growth factor analogs
ES2196082T3 (es) 1994-10-13 2003-12-16 Amgen Inc Analagos del factor de crecimiento de queratinocitos.

Also Published As

Publication number Publication date
NZ266622A (en) 1997-10-24
JP3570516B2 (ja) 2004-09-29
CZ343795A3 (en) 1996-07-17
ATE278777T1 (de) 2004-10-15
US6677301B1 (en) 2004-01-13
ES2227527T3 (es) 2005-04-01
BR9407035A (pt) 1996-03-12
US20090093400A1 (en) 2009-04-09
JP2004166709A (ja) 2004-06-17
CN1129955A (zh) 1996-08-28
FR06C0004I1 (nl) 2006-03-10
DE122006000005I2 (de) 2006-11-23
PL312257A1 (en) 1996-04-01
EP0706563B1 (en) 2004-10-06
NO955189L (no) 1995-12-20
JP2006075173A (ja) 2006-03-23
LU91215I2 (en) 2006-03-27
EP0706563A1 (en) 1996-04-17
EP1493812A3 (en) 2006-02-08
BG100236A (en) 1996-07-31
US5843883A (en) 1998-12-01
KR960703433A (ko) 1996-08-17
FR06C0004I2 (fr) 2006-12-29
DE122006000005I1 (de) 2006-08-10
US5863767A (en) 1999-01-26
JPH09500267A (ja) 1997-01-14
US5773586A (en) 1998-06-30
FI956203A0 (fi) 1995-12-22
PT706563E (pt) 2005-01-31
AU6820894A (en) 1995-01-24
DE69434053T2 (de) 2006-02-23
DK0706563T3 (da) 2005-01-31
WO1995001434A1 (en) 1995-01-12
FI956203A (fi) 1996-02-07
NO955189D0 (no) 1995-12-20
CA2166278A1 (en) 1995-01-12
HUT73453A (en) 1996-08-28
JP2009062396A (ja) 2009-03-26
US5677278A (en) 1997-10-14
AU681405B2 (en) 1997-08-28
EP1493812A2 (en) 2005-01-05
HU9503857D0 (en) 1996-02-28
SK153295A3 (en) 1996-11-06
DE69434053D1 (de) 2005-01-20
NL300217I1 (nl) 2006-04-03
JP4662569B2 (ja) 2011-03-30
US6074848A (en) 2000-06-13

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