FI955256A - Skvaleenisyntaasin fosfonosulfonaatti-inhibiittorin suoloja ja menetelmä - Google Patents

Skvaleenisyntaasin fosfonosulfonaatti-inhibiittorin suoloja ja menetelmä Download PDF

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Publication number
FI955256A
FI955256A FI955256A FI955256A FI955256A FI 955256 A FI955256 A FI 955256A FI 955256 A FI955256 A FI 955256A FI 955256 A FI955256 A FI 955256A FI 955256 A FI955256 A FI 955256A
Authority
FI
Finland
Prior art keywords
phosphonosulfonate
inhibitor
salts
squalene synthase
squalene
Prior art date
Application number
FI955256A
Other languages
English (en)
Swedish (sv)
Other versions
FI955256A0 (fi
Inventor
Yadagiri Pendri
Chung-Pin Chen
David J Kucera
Eduardo J Martinez
Paul D Pansegrau
John K Thottathil
Peter Timmins
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FI955256A0 publication Critical patent/FI955256A0/fi
Publication of FI955256A publication Critical patent/FI955256A/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075Esters with hydroxyalkyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
FI955256A 1994-11-03 1995-11-02 Skvaleenisyntaasin fosfonosulfonaatti-inhibiittorin suoloja ja menetelmä FI955256A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33366194A 1994-11-03 1994-11-03

Publications (2)

Publication Number Publication Date
FI955256A0 FI955256A0 (fi) 1995-11-02
FI955256A true FI955256A (fi) 1996-05-04

Family

ID=23303735

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955256A FI955256A (fi) 1994-11-03 1995-11-02 Skvaleenisyntaasin fosfonosulfonaatti-inhibiittorin suoloja ja menetelmä

Country Status (14)

Country Link
EP (1) EP0710665A1 (fi)
JP (1) JPH08208672A (fi)
KR (1) KR960017680A (fi)
CN (1) CN1130188A (fi)
AU (1) AU3458795A (fi)
CA (1) CA2159850A1 (fi)
CZ (1) CZ279595A3 (fi)
FI (1) FI955256A (fi)
HU (1) HUT73140A (fi)
IL (1) IL115537A0 (fi)
NO (1) NO954389L (fi)
PL (1) PL311218A1 (fi)
TW (1) TW318852B (fi)
ZA (1) ZA959326B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780974B1 (fr) * 1998-07-08 2001-09-28 Sod Conseils Rech Applic Utilisation de derives d'imidazopyrazines pour preparer un medicament destine a traiter les pathologies qui resultent de la formation de la proteine g heterotrimetrique
WO2002038180A1 (fr) * 2000-11-09 2002-05-16 Takeda Chemical Industries, Ltd. Agent haute densite faisant monter le taux de lipoproteine-cholesterol
CN101198252A (zh) 2005-04-18 2008-06-11 加利福尼亚大学董事会 用于细菌感染的抗微生物疗法
JP5161872B2 (ja) 2006-05-12 2013-03-13 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 細菌感染に対する抗微生物療法
CN101580472B (zh) * 2009-06-24 2013-07-10 广西壮族自治区化工研究院 1,1'-联-2-萘酚的拆分剂以及拆分方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ248852A (en) * 1992-10-28 1997-06-24 Squibb & Sons Inc Alpha-phosphono and phosphinosulphonates and medicaments thereof
US5312814A (en) * 1992-12-09 1994-05-17 Bristol-Myers Squibb Co. α-phosphonocarboxylate squalene synthetase inhibitors

Also Published As

Publication number Publication date
HUT73140A (en) 1996-06-28
NO954389D0 (no) 1995-11-02
TW318852B (fi) 1997-11-01
CA2159850A1 (en) 1996-05-04
EP0710665A1 (en) 1996-05-08
CN1130188A (zh) 1996-09-04
AU3458795A (en) 1996-05-09
PL311218A1 (en) 1996-05-13
KR960017680A (ko) 1996-06-17
CZ279595A3 (en) 1996-08-14
NO954389L (no) 1996-05-06
HU9503136D0 (en) 1995-12-28
FI955256A0 (fi) 1995-11-02
JPH08208672A (ja) 1996-08-13
ZA959326B (en) 1997-05-05
IL115537A0 (en) 1996-01-19

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