FI954048A0 - Herpes-virus-rikbonukleotidireduktaasin estäjät - Google Patents

Herpes-virus-rikbonukleotidireduktaasin estäjät

Info

Publication number
FI954048A0
FI954048A0 FI954048A FI954048A FI954048A0 FI 954048 A0 FI954048 A0 FI 954048A0 FI 954048 A FI954048 A FI 954048A FI 954048 A FI954048 A FI 954048A FI 954048 A0 FI954048 A0 FI 954048A0
Authority
FI
Finland
Prior art keywords
alkyl
nhch
amino acid
inhibitors
herpes virus
Prior art date
Application number
FI954048A
Other languages
English (en)
Swedish (sv)
Other versions
FI954048A (fi
Inventor
Robert Deziel
Neil Moss
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of FI954048A publication Critical patent/FI954048A/fi
Publication of FI954048A0 publication Critical patent/FI954048A0/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI954048A 1993-03-03 1995-08-29 Herpes-virus-rikbonukleotidireduktaasin estäjät FI954048A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2554093A 1993-03-03 1993-03-03
PCT/CA1994/000106 WO1994020528A1 (en) 1993-03-03 1994-02-28 Inhibitors of herpes viral ribonucleotide reductase

Publications (2)

Publication Number Publication Date
FI954048A FI954048A (fi) 1995-08-29
FI954048A0 true FI954048A0 (fi) 1995-08-29

Family

ID=21826675

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954048A FI954048A0 (fi) 1993-03-03 1995-08-29 Herpes-virus-rikbonukleotidireduktaasin estäjät

Country Status (27)

Country Link
US (1) US5476841A (fi)
EP (1) EP0618226B1 (fi)
JP (1) JPH08507760A (fi)
KR (1) KR960701090A (fi)
CN (1) CN1118601A (fi)
AT (1) ATE197802T1 (fi)
AU (1) AU683450B2 (fi)
BG (1) BG99889A (fi)
BR (1) BR9406346A (fi)
CA (1) CA2157196C (fi)
CZ (1) CZ224295A3 (fi)
DE (1) DE69426337T2 (fi)
DK (1) DK0618226T3 (fi)
ES (1) ES2152269T3 (fi)
FI (1) FI954048A0 (fi)
GR (1) GR3035295T3 (fi)
HU (1) HUT72894A (fi)
IL (1) IL108818A0 (fi)
LV (1) LV11037B (fi)
NO (1) NO953437L (fi)
NZ (1) NZ262073A (fi)
PL (1) PL310447A1 (fi)
PT (1) PT618226E (fi)
SG (1) SG65553A1 (fi)
SK (1) SK106095A3 (fi)
WO (1) WO1994020528A1 (fi)
ZA (1) ZA941449B (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
CA2564868C (en) * 2004-04-28 2013-11-26 Molecules For Health, Inc. Methods for treating or preventing restenosis and other vascular proliferative disorders
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411334B1 (en) * 1989-07-07 1995-02-22 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
JPH03181498A (ja) * 1989-12-07 1991-08-07 Merck & Co Inc ペプチド抗ウイルス剤
CA2033448C (en) * 1990-12-31 1996-11-26 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes compositions and method of use

Also Published As

Publication number Publication date
CA2157196A1 (en) 1994-09-15
ZA941449B (en) 1994-10-14
JPH08507760A (ja) 1996-08-20
LV11037A (lv) 1996-02-20
NO953437D0 (no) 1995-09-01
PT618226E (pt) 2001-03-30
GR3035295T3 (en) 2001-04-30
FI954048A (fi) 1995-08-29
ES2152269T3 (es) 2001-02-01
AU6151694A (en) 1994-09-26
IL108818A0 (en) 1994-06-24
DE69426337T2 (de) 2001-05-31
BR9406346A (pt) 1996-02-21
HUT72894A (en) 1996-06-28
CN1118601A (zh) 1996-03-13
US5476841A (en) 1995-12-19
HU9502570D0 (en) 1995-11-28
DE69426337D1 (de) 2001-01-04
SG65553A1 (en) 1999-06-22
EP0618226B1 (en) 2000-11-29
WO1994020528A1 (en) 1994-09-15
PL310447A1 (en) 1995-12-11
BG99889A (en) 1996-02-28
LV11037B (en) 1996-06-20
CA2157196C (en) 2000-06-13
KR960701090A (ko) 1996-02-24
SK106095A3 (en) 1996-02-07
ATE197802T1 (de) 2000-12-15
NZ262073A (en) 1997-07-27
NO953437L (no) 1995-09-01
AU683450B2 (en) 1997-11-13
DK0618226T3 (da) 2000-12-27
EP0618226A1 (en) 1994-10-05
CZ224295A3 (en) 1996-02-14

Similar Documents

Publication Publication Date Title
EP0461546A3 (en) Antiherpes peptide derivatives having a 1,4-dioxo-c4 n-terminus
FI954048A0 (fi) Herpes-virus-rikbonukleotidireduktaasin estäjät
LV10461A (lv) Izosterie peptidu atvasinajumi ar pretherpesa ipasibam
ZA931746B (en) Antiherpes peptide derivatives having a ureido N-terminus
GB2340490A (en) Diphenylacetic acid derivatives and their use as antiviral agents

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: BOEHRINGER INGELHEIM (CANADA) LTD.

FD Application lapsed