BG99889A - Inhibitors of ribonucleotide reductase of the herpes virus - Google Patents

Inhibitors of ribonucleotide reductase of the herpes virus

Info

Publication number
BG99889A
BG99889A BG99889A BG9988995A BG99889A BG 99889 A BG99889 A BG 99889A BG 99889 A BG99889 A BG 99889A BG 9988995 A BG9988995 A BG 9988995A BG 99889 A BG99889 A BG 99889A
Authority
BG
Bulgaria
Prior art keywords
alkyl
nhch
amino acid
inhibitors
herpes virus
Prior art date
Application number
BG99889A
Other languages
Bulgarian (bg)
English (en)
Inventor
Robert Deziel
Neil Moss
Original Assignee
Robert Deziel
Neil Moss
Boehringer Ingelheim /Canada/ Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Deziel, Neil Moss, Boehringer Ingelheim /Canada/ Ltd. filed Critical Robert Deziel
Publication of BG99889A publication Critical patent/BG99889A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
BG99889A 1993-03-03 1995-08-28 Inhibitors of ribonucleotide reductase of the herpes virus BG99889A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2554093A 1993-03-03 1993-03-03
PCT/CA1994/000106 WO1994020528A1 (en) 1993-03-03 1994-02-28 Inhibitors of herpes viral ribonucleotide reductase

Publications (1)

Publication Number Publication Date
BG99889A true BG99889A (en) 1996-02-28

Family

ID=21826675

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99889A BG99889A (en) 1993-03-03 1995-08-28 Inhibitors of ribonucleotide reductase of the herpes virus

Country Status (27)

Country Link
US (1) US5476841A (xx)
EP (1) EP0618226B1 (xx)
JP (1) JPH08507760A (xx)
KR (1) KR960701090A (xx)
CN (1) CN1118601A (xx)
AT (1) ATE197802T1 (xx)
AU (1) AU683450B2 (xx)
BG (1) BG99889A (xx)
BR (1) BR9406346A (xx)
CA (1) CA2157196C (xx)
CZ (1) CZ224295A3 (xx)
DE (1) DE69426337T2 (xx)
DK (1) DK0618226T3 (xx)
ES (1) ES2152269T3 (xx)
FI (1) FI954048A0 (xx)
GR (1) GR3035295T3 (xx)
HU (1) HUT72894A (xx)
IL (1) IL108818A0 (xx)
LV (1) LV11037B (xx)
NO (1) NO953437L (xx)
NZ (1) NZ262073A (xx)
PL (1) PL310447A1 (xx)
PT (1) PT618226E (xx)
SG (1) SG65553A1 (xx)
SK (1) SK106095A3 (xx)
WO (1) WO1994020528A1 (xx)
ZA (1) ZA941449B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
US8029815B2 (en) * 2004-04-28 2011-10-04 Elford Howard L Methods for treating or preventing restenosis and other vascular proliferative disorders
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411334B1 (en) * 1989-07-07 1995-02-22 Bio-Mega/Boehringer Ingelheim Research Inc. Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
JPH03181498A (ja) * 1989-12-07 1991-08-07 Merck & Co Inc ペプチド抗ウイルス剤
CA2033448C (en) * 1990-12-31 1996-11-26 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes compositions and method of use

Also Published As

Publication number Publication date
NO953437D0 (no) 1995-09-01
SG65553A1 (en) 1999-06-22
ATE197802T1 (de) 2000-12-15
CA2157196A1 (en) 1994-09-15
PL310447A1 (en) 1995-12-11
FI954048A (fi) 1995-08-29
ZA941449B (en) 1994-10-14
IL108818A0 (en) 1994-06-24
DK0618226T3 (da) 2000-12-27
HU9502570D0 (en) 1995-11-28
NZ262073A (en) 1997-07-27
LV11037A (lv) 1996-02-20
DE69426337D1 (de) 2001-01-04
US5476841A (en) 1995-12-19
ES2152269T3 (es) 2001-02-01
DE69426337T2 (de) 2001-05-31
AU683450B2 (en) 1997-11-13
EP0618226A1 (en) 1994-10-05
JPH08507760A (ja) 1996-08-20
WO1994020528A1 (en) 1994-09-15
HUT72894A (en) 1996-06-28
LV11037B (en) 1996-06-20
CZ224295A3 (en) 1996-02-14
GR3035295T3 (en) 2001-04-30
NO953437L (no) 1995-09-01
FI954048A0 (fi) 1995-08-29
PT618226E (pt) 2001-03-30
AU6151694A (en) 1994-09-26
BR9406346A (pt) 1996-02-21
SK106095A3 (en) 1996-02-07
CA2157196C (en) 2000-06-13
CN1118601A (zh) 1996-03-13
KR960701090A (ko) 1996-02-24
EP0618226B1 (en) 2000-11-29

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