BG99889A - Инхибитори на рибонуклеотидната редуктаза на херпесния вирус - Google Patents

Инхибитори на рибонуклеотидната редуктаза на херпесния вирус

Info

Publication number
BG99889A
BG99889A BG99889A BG9988995A BG99889A BG 99889 A BG99889 A BG 99889A BG 99889 A BG99889 A BG 99889A BG 9988995 A BG9988995 A BG 9988995A BG 99889 A BG99889 A BG 99889A
Authority
BG
Bulgaria
Prior art keywords
alkyl
nhch
amino acid
inhibitors
herpes virus
Prior art date
Application number
BG99889A
Other languages
English (en)
Inventor
Robert Deziel
Neil Moss
Original Assignee
Robert Deziel
Neil Moss
Boehringer Ingelheim /Canada/ Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Deziel, Neil Moss, Boehringer Ingelheim /Canada/ Ltd. filed Critical Robert Deziel
Publication of BG99889A publication Critical patent/BG99889A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретението се отнася до пептидни производни с формула А-В-D-NHCH-{CH2C(O)R1}C(O)-NHCH{CR2(R3)-COOH}C(O)-E, в която А е нисш алканоил, носещ два заместителя, като всеки заместител е избран независимо измежду фенил или монозаместен фенил, при който монозаместителят е алкил, халоген, хидрокси илиалкокси, В е N-метиламинокиселинен остатък, D е аминокиселинен остатък, R1 е алкил, циклоалкил монозаместена аминогрупа или дизаместена аминогрупа, R2 е водород или алкил и R3 е алкил, или R2 и R3 сасвързани, образувайки циклоалкил, а Е е определена група, например алкиламино- или моновалентен аминокиселинен радикал като NHCH(алкил)С(0)ОН. Производните са приложими при лечение на херпесни инфекции.
BG99889A 1993-03-03 1995-08-28 Инхибитори на рибонуклеотидната редуктаза на херпесния вирус BG99889A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2554093A 1993-03-03 1993-03-03
PCT/CA1994/000106 WO1994020528A1 (en) 1993-03-03 1994-02-28 Inhibitors of herpes viral ribonucleotide reductase

Publications (1)

Publication Number Publication Date
BG99889A true BG99889A (bg) 1996-02-28

Family

ID=21826675

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99889A BG99889A (bg) 1993-03-03 1995-08-28 Инхибитори на рибонуклеотидната редуктаза на херпесния вирус

Country Status (27)

Country Link
US (1) US5476841A (bg)
EP (1) EP0618226B1 (bg)
JP (1) JPH08507760A (bg)
KR (1) KR960701090A (bg)
CN (1) CN1118601A (bg)
AT (1) ATE197802T1 (bg)
AU (1) AU683450B2 (bg)
BG (1) BG99889A (bg)
BR (1) BR9406346A (bg)
CA (1) CA2157196C (bg)
CZ (1) CZ224295A3 (bg)
DE (1) DE69426337T2 (bg)
DK (1) DK0618226T3 (bg)
ES (1) ES2152269T3 (bg)
FI (1) FI954048A (bg)
GR (1) GR3035295T3 (bg)
HU (1) HUT72894A (bg)
IL (1) IL108818A0 (bg)
LV (1) LV11037B (bg)
NO (1) NO953437D0 (bg)
NZ (1) NZ262073A (bg)
PL (1) PL310447A1 (bg)
PT (1) PT618226E (bg)
SG (1) SG65553A1 (bg)
SK (1) SK106095A3 (bg)
WO (1) WO1994020528A1 (bg)
ZA (1) ZA941449B (bg)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
CA2152541C (en) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Herpes ribonucleotide reductase inhibitors
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
EP1744761A4 (en) * 2004-04-28 2010-01-13 Molecules For Health Inc METHOD FOR THE TREATMENT OR PREVENTION OF RESTENOSIS AND OTHER PROLIFERATIVE VASCULAR DISORDER
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE118785T1 (de) * 1989-07-07 1995-03-15 Bio Mega Boehringer Ingelheim Pentapeptidderivate, wirksam gegen herpes, die eine ersetzte asparaginsäureseitenkette enthalten.
JPH03181498A (ja) * 1989-12-07 1991-08-07 Merck & Co Inc ペプチド抗ウイルス剤
CA2033448C (en) * 1990-12-31 1996-11-26 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Antiherpes compositions and method of use

Also Published As

Publication number Publication date
NO953437L (no) 1995-09-01
WO1994020528A1 (en) 1994-09-15
DE69426337T2 (de) 2001-05-31
SK106095A3 (en) 1996-02-07
CA2157196C (en) 2000-06-13
DK0618226T3 (da) 2000-12-27
HUT72894A (en) 1996-06-28
LV11037A (lv) 1996-02-20
CA2157196A1 (en) 1994-09-15
HU9502570D0 (en) 1995-11-28
KR960701090A (ko) 1996-02-24
ZA941449B (en) 1994-10-14
CZ224295A3 (en) 1996-02-14
ATE197802T1 (de) 2000-12-15
PT618226E (pt) 2001-03-30
AU683450B2 (en) 1997-11-13
GR3035295T3 (en) 2001-04-30
LV11037B (en) 1996-06-20
AU6151694A (en) 1994-09-26
IL108818A0 (en) 1994-06-24
PL310447A1 (en) 1995-12-11
NZ262073A (en) 1997-07-27
EP0618226B1 (en) 2000-11-29
FI954048A0 (fi) 1995-08-29
DE69426337D1 (de) 2001-01-04
EP0618226A1 (en) 1994-10-05
US5476841A (en) 1995-12-19
BR9406346A (pt) 1996-02-21
JPH08507760A (ja) 1996-08-20
SG65553A1 (en) 1999-06-22
FI954048A (fi) 1995-08-29
ES2152269T3 (es) 2001-02-01
NO953437D0 (no) 1995-09-01
CN1118601A (zh) 1996-03-13

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