FI953866A0 - Indolin-2-onderivat - Google Patents

Indolin-2-onderivat

Info

Publication number
FI953866A0
FI953866A0 FI953866A FI953866A FI953866A0 FI 953866 A0 FI953866 A0 FI 953866A0 FI 953866 A FI953866 A FI 953866A FI 953866 A FI953866 A FI 953866A FI 953866 A0 FI953866 A0 FI 953866A0
Authority
FI
Finland
Prior art keywords
lower alkyl
heterocycle
aryl
acyl
treatment
Prior art date
Application number
FI953866A
Other languages
English (en)
Finnish (fi)
Other versions
FI112652B (sv
FI953866A (sv
Inventor
Toru Esaki
Takashi Emura
Eiichi Hoshino
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of FI953866A0 publication Critical patent/FI953866A0/sv
Publication of FI953866A publication Critical patent/FI953866A/sv
Application granted granted Critical
Publication of FI112652B publication Critical patent/FI112652B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
FI953866A 1993-02-17 1995-08-16 Förfarande för framställning av nya terapeutiskt användbara indolin-2-onderivat FI112652B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6729793 1993-02-17
JP6729793 1993-02-17
JP16726293 1993-05-31
JP16726293 1993-05-31
PCT/JP1994/000235 WO1994019322A1 (en) 1993-02-17 1994-02-17 Indolin-2-one derivative
JP9400235 1994-02-17

Publications (3)

Publication Number Publication Date
FI953866A0 true FI953866A0 (sv) 1995-08-16
FI953866A FI953866A (sv) 1995-08-16
FI112652B FI112652B (sv) 2003-12-31

Family

ID=26408486

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953866A FI112652B (sv) 1993-02-17 1995-08-16 Förfarande för framställning av nya terapeutiskt användbara indolin-2-onderivat

Country Status (19)

Country Link
US (5) US5952511A (sv)
EP (1) EP0685463B1 (sv)
JP (1) JP3419539B2 (sv)
KR (1) KR100226310B1 (sv)
CN (1) CN1046268C (sv)
AT (1) ATE217864T1 (sv)
AU (1) AU6044894A (sv)
CA (1) CA2156287C (sv)
CZ (1) CZ290504B6 (sv)
DE (1) DE69430664T2 (sv)
ES (1) ES2176236T3 (sv)
FI (1) FI112652B (sv)
HU (1) HUT74105A (sv)
MY (1) MY128102A (sv)
NO (1) NO305201B1 (sv)
PL (1) PL176710B1 (sv)
RU (1) RU2128170C1 (sv)
TW (1) TW281669B (sv)
WO (1) WO1994019322A1 (sv)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US5783701A (en) * 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0731091B1 (en) * 1993-11-26 2002-01-02 Tanabe Seiyaku Co., Ltd. 2-oxoindoline derivatives as cholecystokinin receptor antagonists
ATE184594T1 (de) * 1994-03-07 1999-10-15 Vertex Pharma Sulfonamidderivate als aspartylprotease- inhibitoren
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
WO1997033867A1 (fr) * 1996-03-11 1997-09-18 Ube Industries, Ltd. Procede de preparation de composes d'indole actifs sur le plan optique
WO1998002419A1 (fr) * 1996-07-12 1998-01-22 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation de cellules cancereuses
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
CA2335477C (en) 1998-06-19 2010-11-30 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
AU1648600A (en) * 1998-12-04 2000-06-26 Neurosearch A/S Use of isatin derivatives as ion channel activating agents
US6605623B1 (en) 1998-12-18 2003-08-12 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
AU2318600A (en) 1999-01-29 2000-08-18 Chugai Seiyaku Kabushiki Kaisha Chondrongenesis promotors and indolin-2-one derivatives
ATE425142T1 (de) * 1999-04-23 2009-03-15 Vertex Pharma Inhibitoren von c-jun n-terminal kinasen (jnk)
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
PT1233958E (pt) * 1999-11-23 2011-09-20 Methylgene Inc Inibidores de histona desacetilase
AU2001236058A1 (en) * 2000-03-10 2001-09-17 Chugai Seiyaku Kabushiki Kaisha Preparations for chondrogenesis
US7612065B2 (en) 2000-04-21 2009-11-03 Vertex Pharmaceuticals Incorporated Inhibitors of c-JUN N-terminal kinases (JNK)
CA2413418A1 (en) 2000-06-21 2001-12-27 Joseph B. Santella Piperidine amides as modulators of chemokine receptor activity
CA2413274A1 (en) * 2000-06-21 2001-12-27 George V. Delucca N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
CA2508290C (en) 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
CN1251698C (zh) * 2003-01-30 2006-04-19 普文英 一种治疗内毒素血症的板蓝根提取物和用途
WO2008027692A2 (en) * 2006-08-02 2008-03-06 Abu-Ageel Nayef M Led-based illumination system
US20090050905A1 (en) * 2007-08-20 2009-02-26 Abu-Ageel Nayef M Highly Efficient Light-Emitting Diode
WO2010090862A2 (en) * 2009-01-21 2010-08-12 Abu-Ageel Nayef M Illumination system utilizing wavelength conversion materials and light recycling
WO2011053542A1 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Heterocycle amide t-type calcium channel antagonists
CN102516153B (zh) * 2011-12-14 2014-03-12 南京工业大学 5-氟吲哚-2-酮-3-脲类化合物及其制备方法和应用
JP6502939B2 (ja) 2013-11-22 2019-04-17 シーエル バイオサイエンシズ リミティド ライアビリティ カンパニー 骨粗鬆症の処置及び予防のためのガストリン拮抗薬
KR102161674B1 (ko) * 2014-02-18 2020-10-05 주식회사 대웅제약 이사틴 유도체 및 이의 제조방법
CN113456631B (zh) * 2021-08-06 2022-06-21 徐州医科大学 一种靶向acsl1的小分子药物及其在治疗子宫内膜癌中的应用

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US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
JPS62228072A (ja) 1985-12-20 1987-10-06 Kissei Pharmaceut Co Ltd ３−アミノインドリン−２−オン誘導体
JPS62234080A (ja) 1985-12-20 1987-10-14 Kissei Pharmaceut Co Ltd インドリン−２−オン誘導体
US4760083A (en) 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
JPS62270576A (ja) 1986-05-19 1987-11-24 Kissei Pharmaceut Co Ltd イサチン誘導体
JPS63156771A (ja) 1986-12-19 1988-06-29 Kissei Pharmaceut Co Ltd ３−アミノインドリン−２−オン誘導体
JPS62156771A (ja) * 1986-12-19 1987-07-11 Tokyo Shokai:Kk 処方箋処理装置
US4876259A (en) * 1987-01-05 1989-10-24 E. I. Du Pont De Nemours And Company 3,3-disubstituted indolines
EP0442878A4 (en) * 1988-04-05 1991-10-23 Abbott Laboratories Derivatives of tryptophan as cck antagonists
ES2167312T3 (es) * 1990-08-31 2002-05-16 Warner Lambert Co Profarmacos para antagonistas de la colecistoquinina.
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Also Published As

Publication number Publication date
DE69430664D1 (de) 2002-06-27
CZ290504B6 (cs) 2002-08-14
CA2156287C (en) 2005-12-27
EP0685463A1 (en) 1995-12-06
KR960701011A (ko) 1996-02-24
MY128102A (en) 2007-01-31
JP3419539B2 (ja) 2003-06-23
PL310168A1 (en) 1995-11-27
US6031111A (en) 2000-02-29
HUT74105A (en) 1996-11-28
CZ209695A3 (en) 1995-12-13
EP0685463B1 (en) 2002-05-22
FI112652B (sv) 2003-12-31
US5952511A (en) 1999-09-14
ATE217864T1 (de) 2002-06-15
WO1994019322A1 (en) 1994-09-01
JPH0748349A (ja) 1995-02-21
EP0685463A4 (sv) 1996-01-03
NO953235D0 (no) 1995-08-17
NO953235L (no) 1995-10-09
ES2176236T3 (es) 2002-12-01
PL176710B1 (pl) 1999-07-30
HU9502415D0 (en) 1996-05-28
US6127544A (en) 2000-10-03
RU2128170C1 (ru) 1999-03-27
TW281669B (sv) 1996-07-21
KR100226310B1 (ko) 1999-10-15
US6207836B1 (en) 2001-03-27
DE69430664T2 (de) 2003-01-30
CN1046268C (zh) 1999-11-10
US6114536A (en) 2000-09-05
CA2156287A1 (en) 1994-09-01
NO305201B1 (no) 1999-04-19
AU6044894A (en) 1994-09-14
FI953866A (sv) 1995-08-16
CN1117727A (zh) 1996-02-28

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