FI952361A0 - Substituoidut amidinoyhdisteet, niiden valmistus ja hoitomenetelmiä - Google Patents
Substituoidut amidinoyhdisteet, niiden valmistus ja hoitomenetelmiäInfo
- Publication number
- FI952361A0 FI952361A0 FI952361A FI952361A FI952361A0 FI 952361 A0 FI952361 A0 FI 952361A0 FI 952361 A FI952361 A FI 952361A FI 952361 A FI952361 A FI 952361A FI 952361 A0 FI952361 A0 FI 952361A0
- Authority
- FI
- Finland
- Prior art keywords
- radical
- hydrocarbon radical
- pct
- aliphatic hydrocarbon
- carboxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/20—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/978,004 US5451700A (en) | 1991-06-11 | 1992-11-18 | Amidino compounds, their manufacture and methods of treatment |
PCT/US1993/010876 WO1994011341A1 (en) | 1992-11-18 | 1993-11-12 | Substituted amidino compounds, their manufacture and methods of treatment |
Publications (2)
Publication Number | Publication Date |
---|---|
FI952361A FI952361A (fi) | 1995-05-15 |
FI952361A0 true FI952361A0 (fi) | 1995-05-15 |
Family
ID=25525722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI952361A FI952361A0 (fi) | 1992-11-18 | 1995-05-15 | Substituoidut amidinoyhdisteet, niiden valmistus ja hoitomenetelmiä |
Country Status (22)
Country | Link |
---|---|
US (2) | US5451700A (fi) |
EP (1) | EP0669909B1 (fi) |
JP (1) | JP2795986B2 (fi) |
KR (1) | KR100311701B1 (fi) |
AT (1) | ATE161826T1 (fi) |
AU (1) | AU683436B2 (fi) |
CA (1) | CA2148930A1 (fi) |
DE (1) | DE69316236T2 (fi) |
DK (1) | DK0669909T3 (fi) |
ES (1) | ES2111896T3 (fi) |
FI (1) | FI952361A0 (fi) |
GR (1) | GR3025953T3 (fi) |
HU (1) | HU218795B (fi) |
IL (1) | IL107568A (fi) |
MX (1) | MX9307208A (fi) |
NO (1) | NO304978B1 (fi) |
NZ (1) | NZ258368A (fi) |
PH (1) | PH30115A (fi) |
SG (1) | SG49662A1 (fi) |
TW (1) | TW288007B (fi) |
WO (1) | WO1994011341A1 (fi) |
ZA (1) | ZA938574B (fi) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
WO1995011014A1 (en) * | 1993-10-21 | 1995-04-27 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
DE4424713A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe |
ATE178589T1 (de) | 1994-09-20 | 1999-04-15 | Ono Pharmaceutical Co | Amidinophenol-derivate als protease-hemmende verbindungen |
ATE251141T1 (de) * | 1995-03-10 | 2003-10-15 | Berlex Lab | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
CA2253823A1 (en) * | 1996-05-06 | 1997-11-13 | Brigham And Women's Hospital | 5-lipoxygenase gene polymorphisms and their use in classifying patients |
US6008234A (en) * | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
ATE228513T1 (de) | 1996-09-12 | 2002-12-15 | Schering Ag | Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien |
CA2265996A1 (en) | 1996-09-26 | 1998-04-02 | Roger Aki Fujimoto | Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity |
US20030124053A1 (en) * | 1996-10-07 | 2003-07-03 | Barrett John Andrew | Radiopharmaceuticals for imaging infection and inflammation |
US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
ID24720A (id) * | 1997-12-12 | 2000-08-03 | Novartis Ag | Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis |
US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
PL341044A1 (en) | 1997-12-19 | 2001-03-26 | Schering Ag | Derivatives of orthoantranilic amide as anticoagulants |
US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
US6127376A (en) * | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
US20030119901A1 (en) * | 2001-07-14 | 2003-06-26 | Boehringer Ingelheim Pharma Kg | Pharmaceutical formulation containing an LTB4 antagonist |
EP1408943B1 (de) * | 2001-07-14 | 2005-06-29 | Boehringer Ingelheim Pharma GmbH & Co.KG | Arzneimittelformulierung enthaltend einen ltb4 antagonisten und einen netzmittel |
US8242152B2 (en) * | 2001-07-19 | 2012-08-14 | Dong Wha Pharmaceutical Co., Ltd. | Use of 4-[(4-thiazolyl)phenoxy]alkoxy-benzamidine derivatives for the prophylaxis and treatment of osteoporosis |
KR100454767B1 (ko) * | 2001-07-19 | 2004-11-03 | 동화약품공업주식회사 | 4-[(4-티아졸릴)페녹시]알콕시-벤즈아미딘 유도체의골다공증 예방 및 치료제로서의 용도 |
IL160208A0 (en) * | 2001-08-31 | 2004-07-25 | Neurochem Int Ltd | Amidine derivatives for treating amyloidosis |
EP2311818B1 (en) | 2002-02-28 | 2013-01-16 | Novartis AG | Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug |
US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
CN1980905B (zh) | 2004-07-05 | 2010-04-21 | 同和药品株式会社 | 制备n-羟基-4-{5-[4-(5-异丙基-2-甲基-1,3-噻唑-4-基)-苯氧基]-戊氧基}-苄脒的改进方法 |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
US7813541B2 (en) * | 2005-02-28 | 2010-10-12 | Applied Materials South East Asia Pte. Ltd. | Method and apparatus for detecting defects in wafers |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
KR101461263B1 (ko) | 2005-10-21 | 2014-11-17 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
GB0525671D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
PE20070978A1 (es) * | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
PL2013211T3 (pl) | 2006-04-21 | 2012-08-31 | Novartis Ag | Pochodne puryny do zastosowania jako agoniści receptora adenozyny A2A |
BRPI0717564A2 (pt) | 2006-09-29 | 2013-10-22 | Novartis Ag | Pirazolopirimidinas como inibidores de pi3k lipídeo cinase |
PT2231642E (pt) | 2008-01-11 | 2014-03-12 | Novartis Ag | Pirimidinas como inibidores de quinase |
US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
WO2010013969A2 (en) * | 2008-08-01 | 2010-02-04 | Dong Wha Pharmaceutical Co., Ltd. | A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt |
KR20100014090A (ko) * | 2008-08-01 | 2010-02-10 | 동화약품주식회사 | 벤즈아미딘 유도체 또는 이의 염, 및 비스포스포네이트를 포함하는 골다공증의 예방 또는 치료용 약학 조성물 |
DK2391366T3 (da) | 2009-01-29 | 2013-01-07 | Novartis Ag | Substituerede benzimidazoler til behandling af astrocytomer |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
EP2464649A1 (en) | 2009-08-12 | 2012-06-20 | Novartis AG | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
TR201900259T4 (tr) | 2009-08-17 | 2019-02-21 | Intellikine Llc | Heterosiklik Bileşikler Ve Bunların Kullanımları |
JP5775871B2 (ja) | 2009-08-20 | 2015-09-09 | ノバルティス アーゲー | ヘテロ環式オキシム化合物 |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
EP2673277A1 (en) | 2011-02-10 | 2013-12-18 | Novartis AG | [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase |
US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
MX2013009767A (es) | 2011-02-25 | 2013-10-01 | Irm Llc | Compuestos y composiciones como inhibidores de trk. |
CA2848809A1 (en) | 2011-09-15 | 2013-03-21 | Novartis Ag | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase |
US20150297604A1 (en) | 2012-04-03 | 2015-10-22 | Novartis Ag | Combination Products with Tyrosine Kinase Inhibitors and their Use |
JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
ES2831416T3 (es) | 2014-07-31 | 2021-06-08 | Novartis Ag | Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5922697B2 (ja) * | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−(メタ−アミジノフエノキシ)−化合物 |
US4324794A (en) * | 1980-08-26 | 1982-04-13 | Research Triangle Institute | Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds |
US4717736A (en) * | 1984-01-23 | 1988-01-05 | Merck Frosst Canada, Inc. | Antagonists of slow reacting substances of anaphylaxis |
CA1243322A (en) * | 1984-01-23 | 1988-10-18 | Joshua Rokach | Antagonists of slow reacting substances of anaphylaxis |
US4808604A (en) * | 1985-10-03 | 1989-02-28 | Ciba-Geigy Corporation | N-(substituted phenyl) tetrazol-5-yl carboxamides and anti-allergic use thereof |
CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
US4889871A (en) * | 1987-05-29 | 1989-12-26 | G. D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives |
US4940723A (en) * | 1988-10-20 | 1990-07-10 | University Of North Carolina, Chapel Hill | Use of bis-(5-amidino-2-benzimidazolyl) methane (BABIM) to treat arthritis |
US4933347A (en) * | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
AU626033B2 (en) * | 1988-10-25 | 1992-07-23 | Government Of The United States Of America, As Represented By The Secretary Of The Army, The | Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods |
US4963589A (en) * | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
US5162361A (en) * | 1990-04-10 | 1992-11-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Method of treating diseases associated with elevated levels of interleukin 1 |
US5124350A (en) * | 1990-06-28 | 1992-06-23 | G. D. Searle & Co. | Leukotriene b4 antagonists |
DE4028866A1 (de) * | 1990-09-07 | 1992-03-12 | Schering Ag | Neue leukotrien-b(pfeil abwaerts)4(pfeil abwaerts)-antagonisten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
ES2075672T3 (es) * | 1991-06-11 | 1995-10-01 | Ciba Geigy Ag | Amidinocompuestos, su fabricacion y uso como medicamento. |
US5488160A (en) * | 1991-06-11 | 1996-01-30 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and method of treatment |
EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
US5246965A (en) * | 1991-06-11 | 1993-09-21 | Ciba-Geigy | Arylethers, their manufacture and methods of treatment |
ES2132216T3 (es) * | 1992-02-05 | 1999-08-16 | Boehringer Ingelheim Pharma | Nuevos derivados de amidinas, su preparacion y utilizacion como medicamentos con efecto antagonista de ltb4. |
-
1992
- 1992-11-18 US US07/978,004 patent/US5451700A/en not_active Expired - Lifetime
-
1993
- 1993-11-11 IL IL107568A patent/IL107568A/en not_active IP Right Cessation
- 1993-11-12 NZ NZ258368A patent/NZ258368A/xx unknown
- 1993-11-12 JP JP6512333A patent/JP2795986B2/ja not_active Expired - Fee Related
- 1993-11-12 DK DK94901395.7T patent/DK0669909T3/da active
- 1993-11-12 WO PCT/US1993/010876 patent/WO1994011341A1/en active IP Right Grant
- 1993-11-12 AU AU55994/94A patent/AU683436B2/en not_active Ceased
- 1993-11-12 HU HU9501452A patent/HU218795B/hu not_active IP Right Cessation
- 1993-11-12 ES ES94901395T patent/ES2111896T3/es not_active Expired - Lifetime
- 1993-11-12 EP EP94901395A patent/EP0669909B1/en not_active Expired - Lifetime
- 1993-11-12 DE DE69316236T patent/DE69316236T2/de not_active Expired - Fee Related
- 1993-11-12 PH PH47258A patent/PH30115A/en unknown
- 1993-11-12 US US08/436,368 patent/US5639768A/en not_active Expired - Fee Related
- 1993-11-12 SG SG1996003187A patent/SG49662A1/en unknown
- 1993-11-12 CA CA002148930A patent/CA2148930A1/en not_active Abandoned
- 1993-11-12 AT AT94901395T patent/ATE161826T1/de not_active IP Right Cessation
- 1993-11-12 KR KR1019950701992A patent/KR100311701B1/ko not_active IP Right Cessation
- 1993-11-17 ZA ZA938574A patent/ZA938574B/xx unknown
- 1993-11-18 MX MX9307208A patent/MX9307208A/es not_active IP Right Cessation
- 1993-12-11 TW TW082110504A patent/TW288007B/zh active
-
1995
- 1995-05-15 FI FI952361A patent/FI952361A0/fi unknown
- 1995-05-16 NO NO951934A patent/NO304978B1/no not_active IP Right Cessation
-
1998
- 1998-01-21 GR GR980400123T patent/GR3025953T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH08503466A (ja) | 1996-04-16 |
JP2795986B2 (ja) | 1998-09-10 |
HUT72991A (en) | 1996-06-28 |
US5639768A (en) | 1997-06-17 |
TW288007B (fi) | 1996-10-11 |
US5451700A (en) | 1995-09-19 |
ES2111896T3 (es) | 1998-03-16 |
KR950704238A (ko) | 1995-11-17 |
HU218795B (hu) | 2000-12-28 |
NZ258368A (en) | 1997-10-24 |
GR3025953T3 (en) | 1998-04-30 |
NO951934D0 (no) | 1995-05-16 |
ZA938574B (en) | 1994-08-22 |
DK0669909T3 (da) | 1998-03-30 |
EP0669909B1 (en) | 1998-01-07 |
FI952361A (fi) | 1995-05-15 |
IL107568A0 (en) | 1994-02-27 |
EP0669909A1 (en) | 1995-09-06 |
ATE161826T1 (de) | 1998-01-15 |
HU9501452D0 (en) | 1995-06-28 |
MX9307208A (es) | 1994-07-29 |
DE69316236T2 (de) | 1998-08-13 |
PH30115A (en) | 1996-12-27 |
NO951934L (no) | 1995-06-28 |
AU683436B2 (en) | 1997-11-13 |
SG49662A1 (en) | 1999-05-25 |
KR100311701B1 (ko) | 2002-11-30 |
DE69316236D1 (de) | 1998-02-12 |
IL107568A (en) | 1998-01-04 |
NO304978B1 (no) | 1999-03-15 |
CA2148930A1 (en) | 1994-05-26 |
AU5599494A (en) | 1994-06-08 |
WO1994011341A1 (en) | 1994-05-26 |
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Legal Events
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GB | Transfer or assigment of application |
Owner name: NOVARTIS AG |