DE69316236D1 - Substituierte amidinverbindungen, ihre herstellung und behandlungsmethoden - Google Patents

Substituierte amidinverbindungen, ihre herstellung und behandlungsmethoden

Info

Publication number
DE69316236D1
DE69316236D1 DE69316236T DE69316236T DE69316236D1 DE 69316236 D1 DE69316236 D1 DE 69316236D1 DE 69316236 T DE69316236 T DE 69316236T DE 69316236 T DE69316236 T DE 69316236T DE 69316236 D1 DE69316236 D1 DE 69316236D1
Authority
DE
Germany
Prior art keywords
radical
hydrocarbon radical
pct
aliphatic hydrocarbon
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69316236T
Other languages
English (en)
Other versions
DE69316236T2 (de
Inventor
Michael Morrissey
Hongsuk Suh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of DE69316236D1 publication Critical patent/DE69316236D1/de
Publication of DE69316236T2 publication Critical patent/DE69316236T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/20—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69316236T 1992-11-18 1993-11-12 Substituierte amidinverbindungen, ihre herstellung und behandlungsmethoden Expired - Fee Related DE69316236T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/978,004 US5451700A (en) 1991-06-11 1992-11-18 Amidino compounds, their manufacture and methods of treatment
PCT/US1993/010876 WO1994011341A1 (en) 1992-11-18 1993-11-12 Substituted amidino compounds, their manufacture and methods of treatment

Publications (2)

Publication Number Publication Date
DE69316236D1 true DE69316236D1 (de) 1998-02-12
DE69316236T2 DE69316236T2 (de) 1998-08-13

Family

ID=25525722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69316236T Expired - Fee Related DE69316236T2 (de) 1992-11-18 1993-11-12 Substituierte amidinverbindungen, ihre herstellung und behandlungsmethoden

Country Status (22)

Country Link
US (2) US5451700A (de)
EP (1) EP0669909B1 (de)
JP (1) JP2795986B2 (de)
KR (1) KR100311701B1 (de)
AT (1) ATE161826T1 (de)
AU (1) AU683436B2 (de)
CA (1) CA2148930A1 (de)
DE (1) DE69316236T2 (de)
DK (1) DK0669909T3 (de)
ES (1) ES2111896T3 (de)
FI (1) FI952361A0 (de)
GR (1) GR3025953T3 (de)
HU (1) HU218795B (de)
IL (1) IL107568A (de)
MX (1) MX9307208A (de)
NO (1) NO304978B1 (de)
NZ (1) NZ258368A (de)
PH (1) PH30115A (de)
SG (1) SG49662A1 (de)
TW (1) TW288007B (de)
WO (1) WO1994011341A1 (de)
ZA (1) ZA938574B (de)

Families Citing this family (63)

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US5821267A (en) * 1993-10-21 1998-10-13 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
DE4424713A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DE69508875T2 (de) 1994-09-20 1999-09-16 Ono Pharmaceutical Co Amidinophenol-Derivate als Protease-hemmende Verbindungen
PT813525E (pt) * 1995-03-10 2004-02-27 Berlex Lab Derivados de benzamidina e sua utilizacao como anticoagulantes
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
WO1997042347A2 (en) * 1996-05-06 1997-11-13 Brigham And Women's Hospital 5-lipoxygenase gene polymorphisms and their use in classifying patients
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
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EP2673277A1 (de) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4] triazolo [4, 3]pyridazinverbindungen als inhibitoren dec-met-tyrosinkinase
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EP2755976B1 (de) 2011-09-15 2018-07-18 Novartis AG 6-substituierte 3-(chinolin-6-ylthio)-[1,2,4-]triazolo-[4,3-a-]pyradine als tyrosinkinase
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TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
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Also Published As

Publication number Publication date
EP0669909B1 (de) 1998-01-07
US5639768A (en) 1997-06-17
KR100311701B1 (ko) 2002-11-30
GR3025953T3 (en) 1998-04-30
JP2795986B2 (ja) 1998-09-10
ZA938574B (en) 1994-08-22
HU218795B (hu) 2000-12-28
DE69316236T2 (de) 1998-08-13
CA2148930A1 (en) 1994-05-26
ES2111896T3 (es) 1998-03-16
NO951934D0 (no) 1995-05-16
ATE161826T1 (de) 1998-01-15
FI952361A (fi) 1995-05-15
HU9501452D0 (en) 1995-06-28
IL107568A0 (en) 1994-02-27
AU683436B2 (en) 1997-11-13
HUT72991A (en) 1996-06-28
IL107568A (en) 1998-01-04
MX9307208A (es) 1994-07-29
FI952361A0 (fi) 1995-05-15
NO304978B1 (no) 1999-03-15
JPH08503466A (ja) 1996-04-16
TW288007B (de) 1996-10-11
US5451700A (en) 1995-09-19
AU5599494A (en) 1994-06-08
NZ258368A (en) 1997-10-24
KR950704238A (ko) 1995-11-17
PH30115A (en) 1996-12-27
WO1994011341A1 (en) 1994-05-26
DK0669909T3 (da) 1998-03-30
EP0669909A1 (de) 1995-09-06
NO951934L (no) 1995-06-28
SG49662A1 (en) 1999-05-25

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