FI950893A0 - Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina - Google Patents

Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina

Info

Publication number
FI950893A0
FI950893A0 FI950893A FI950893A FI950893A0 FI 950893 A0 FI950893 A0 FI 950893A0 FI 950893 A FI950893 A FI 950893A FI 950893 A FI950893 A FI 950893A FI 950893 A0 FI950893 A0 FI 950893A0
Authority
FI
Finland
Prior art keywords
pct
hydroxy
derivatives
nhch2
sch2
Prior art date
Application number
FI950893A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950893A7 (fi
Inventor
George Robert Brown
Keith Blakeney Mallion
Paul Robert Owen Whittamore
David Robert Brittain
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI950893A7 publication Critical patent/FI950893A7/fi
Publication of FI950893A0 publication Critical patent/FI950893A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI950893A 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina FI950893A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929218334A GB9218334D0 (en) 1992-08-28 1992-08-28 Heterocyclic compounds
PCT/GB1993/001802 WO1994005660A1 (en) 1992-08-28 1993-08-24 Quinuclidine derivatives as squalene synthase inhibitors

Publications (2)

Publication Number Publication Date
FI950893A7 FI950893A7 (fi) 1995-02-27
FI950893A0 true FI950893A0 (fi) 1995-02-27

Family

ID=10721113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950893A FI950893A0 (fi) 1992-08-28 1995-02-27 Kinuklidiinijohdannaiset skvaleenisyntaasi-inhibiittoreina

Country Status (13)

Country Link
US (1) US5714496A (enExample)
EP (1) EP0656897B1 (enExample)
JP (1) JPH08502731A (enExample)
AT (1) ATE161843T1 (enExample)
AU (1) AU4969193A (enExample)
CA (2) CA2143430A1 (enExample)
DE (1) DE69316224D1 (enExample)
FI (1) FI950893A0 (enExample)
GB (2) GB9218334D0 (enExample)
IL (1) IL106797A0 (enExample)
TW (1) TW231293B (enExample)
WO (1) WO1994005660A1 (enExample)
ZA (1) ZA936201B (enExample)

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JP2005512974A (ja) * 2001-10-17 2005-05-12 ユ セ ベ ソシエテ アノニム キヌクリジン誘導体、その調製方法、及びｍ２及び／又はｍ３ムスカリン受容体阻害剤としてのその使用
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CN103724343A (zh) 2004-03-25 2014-04-16 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途
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US7772271B2 (en) * 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) * 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) * 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
EA200700243A1 (ru) * 2004-07-14 2007-08-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения гепатита с
CA2578636A1 (en) * 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
CA2584485C (en) 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
CN101365446B (zh) 2005-07-29 2013-05-22 雷斯弗洛吉克斯公司 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
DK2118074T3 (en) 2007-02-01 2014-03-10 Resverlogix Corp Compounds for the prevention and treatment of cardiovascular diseases
ES2532402T3 (es) 2008-06-26 2015-03-26 Resverlogix Corporation Métodos de preparación de derivados de quinazolinona
JP5635535B2 (ja) 2009-01-08 2014-12-03 レスバーロジックス コーポレイション 心血管疾患の予防および治療のための化合物
CN105859639A (zh) 2009-03-18 2016-08-17 雷斯韦洛吉克斯公司 新的抗炎剂
CN107252429B (zh) 2009-04-22 2023-06-16 雷斯韦洛吉克斯公司 新抗炎剂
JP5869677B2 (ja) 2011-09-16 2016-02-24 ファイザー・インク トランスサイレチン解離阻害剤の固体形態
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
US8859553B2 (en) * 2012-07-30 2014-10-14 Astar Biotech Llc Protein kinase inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
CN114984016A (zh) 2015-03-13 2022-09-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

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Also Published As

Publication number Publication date
US5714496A (en) 1998-02-03
IL106797A0 (en) 1993-12-08
CA2104981A1 (en) 1994-03-01
GB9218334D0 (en) 1992-10-14
JPH08502731A (ja) 1996-03-26
ATE161843T1 (de) 1998-01-15
EP0656897B1 (en) 1998-01-07
FI950893A7 (fi) 1995-02-27
WO1994005660A1 (en) 1994-03-17
EP0656897A1 (en) 1995-06-14
GB9317153D0 (en) 1993-10-06
CA2143430A1 (en) 1994-03-17
DE69316224D1 (de) 1998-02-12
AU4969193A (en) 1994-03-29
TW231293B (enExample) 1994-10-01
ZA936201B (en) 1994-02-28

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Legal Events

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