FI945779A0 - Uudet piperatsinyyli-bis-(alkyyliamino)pyrimidiinijohdannaiset ja menetelmä niiden valmistamiseksi - Google Patents

Uudet piperatsinyyli-bis-(alkyyliamino)pyrimidiinijohdannaiset ja menetelmä niiden valmistamiseksi

Info

Publication number
FI945779A0
FI945779A0 FI945779A FI945779A FI945779A0 FI 945779 A0 FI945779 A0 FI 945779A0 FI 945779 A FI945779 A FI 945779A FI 945779 A FI945779 A FI 945779A FI 945779 A0 FI945779 A0 FI 945779A0
Authority
FI
Finland
Prior art keywords
alkylamino
bis
preparation
pyrimidine derivatives
novel piperazinyl
Prior art date
Application number
FI945779A
Other languages
English (en)
Swedish (sv)
Other versions
FI945779A (fi
Inventor
Sandor Maho
Zoltan Tuba
Csaba Santa
Gabor Balogh
Csizer Eva Czajlikne
Marsai Maria Lovasne
Gyoergy Galik
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of FI945779A0 publication Critical patent/FI945779A0/fi
Publication of FI945779A publication Critical patent/FI945779A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI945779A 1992-06-09 1994-12-08 Uudet piperatsinyyli-bis-(alkyyliamino)pyrimidiinijohdannaiset ja menetelmä niiden valmistamiseksi FI945779A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9201907A HUT64323A (en) 1992-06-09 1992-06-09 Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
PCT/HU1993/000034 WO1993025539A1 (en) 1992-06-09 1993-06-08 Novel piperzinyl-bis(alkylamino)pyrimidine derivatives and process for preparing same

Publications (2)

Publication Number Publication Date
FI945779A0 true FI945779A0 (fi) 1994-12-08
FI945779A FI945779A (fi) 1994-12-08

Family

ID=10982017

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945779A FI945779A (fi) 1992-06-09 1994-12-08 Uudet piperatsinyyli-bis-(alkyyliamino)pyrimidiinijohdannaiset ja menetelmä niiden valmistamiseksi

Country Status (11)

Country Link
US (1) US5550240A (fi)
EP (1) EP0644882A1 (fi)
JP (1) JPH07507551A (fi)
KR (1) KR950701916A (fi)
AU (1) AU4352293A (fi)
CA (1) CA2137684A1 (fi)
FI (1) FI945779A (fi)
HU (1) HUT64323A (fi)
RU (1) RU94046379A (fi)
WO (1) WO1993025539A1 (fi)
ZA (1) ZA934038B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL198947B1 (pl) * 2000-04-04 2008-08-29 Fundacja Rozwoju Diagnostyki I Nowe (1-adamantyloamino)pirymidyny, sposób ich wytwarzania, zastosowanie medyczne i kompozycja farmaceutyczna
US20040127502A1 (en) 2001-01-31 2004-07-01 Synaptic Pharmaceutical Corporation Use of GAL3 antagonist for treatment of depression
CA2672805A1 (en) * 2001-01-31 2002-08-08 H. Lundbeck A/S Pyrimidine derivatives
US7081470B2 (en) 2001-01-31 2006-07-25 H. Lundbeck A/S Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
KR100516434B1 (ko) * 2002-04-04 2005-09-22 (주) 비엔씨바이오팜 6-(4-치환된-아닐리노)피리미딘 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물
WO2004052862A1 (ja) 2002-12-10 2004-06-24 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
MXPA06000771A (es) * 2003-07-25 2006-04-18 Ciba Sc Holding Ag Uso de 2,4-bis(alquilamino)-pirimidinas o -quinazolinas substituidas como antimicrobianos.
US7622486B2 (en) * 2004-09-23 2009-11-24 Reddy Us Therapeutics, Inc. Pyridine compounds, process for their preparation and compositions containing them
NL2000323C2 (nl) * 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine-derivaten.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345640A (en) * 1971-02-01 1974-01-30 Shell Int Research Piperazinyl pyrimidines
US4351832A (en) * 1980-04-18 1982-09-28 American Home Products Corporation 2-(Piperazinyl)-4-pyrimidinamines
US4532240A (en) * 1982-09-09 1985-07-30 Warner-Lambert Company Diaminopyrimidines
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5506354A (en) * 1985-09-12 1996-04-09 The Upjohn Company Imidazolylpiperazinyl steroids
ES2078890T3 (es) * 1986-10-09 1996-01-01 Upjohn Co Amino esteroides en c20 a c26.
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
JPH02502824A (ja) * 1987-04-03 1990-09-06 ジ・アップジョン・カンパニー アミノ‐９，１０‐セコステロイド類
US5120843A (en) * 1987-04-27 1992-06-09 Upjohn Pharmaceutically active amines
US4980350A (en) * 1988-02-25 1990-12-25 Merck & Co., Inc. Piperazinylalkylpyrimidines as hypoglycemic agents
EP0496746A1 (en) * 1989-10-25 1992-08-05 The Upjohn Company Pharmaceutically active amino-substituted heteroaryl amines
AU642711B2 (en) * 1990-01-26 1993-10-28 Upjohn Company, The 5-oxygenated-2,4,6-triaminopyrimidines

Also Published As

Publication number Publication date
JPH07507551A (ja) 1995-08-24
AU4352293A (en) 1994-01-04
ZA934038B (en) 1994-01-06
US5550240A (en) 1996-08-27
KR950701916A (ko) 1995-05-17
CA2137684A1 (en) 1993-12-23
WO1993025539A1 (en) 1993-12-23
RU94046379A (ru) 1996-10-27
FI945779A (fi) 1994-12-08
HU9201907D0 (en) 1992-09-28
HUT64323A (en) 1993-12-28
EP0644882A1 (en) 1995-03-29

Similar Documents

Publication Publication Date Title
CY2003003I1 (el) Παραγωγα πυριμιδινης και μεθοδος για την παρασκευη τους
HUT65531A (en) Process for producing pyrimidine derivatives and pharmaceutical preparations containing them
EP0407342A3 (en) Pyrimidine derivatives
PT85551A (en) Process for the preparation of antiviral pyrimidine derivatives and of pharmaceutical compositions containing the same
GB2213146B (en) Pyrimidine derivatives
FI944713A0 (fi) 4-difenyylimetyylipiperidiinijohdannaisia ja menetelmä niiden valmistamiseksi
HU910073D0 (en) Process for the production of herbicide uracil derivatives and preparations containing them
GB2208860B (en) Pyrimidine derivatives
FI940775A0 (fi) alfa-fenyyli-isoseriinijohdannaisten valmistusmentelmä ja niiden käyttö
FI945779A (fi) Uudet piperatsinyyli-bis-(alkyyliamino)pyrimidiinijohdannaiset ja menetelmä niiden valmistamiseksi
IL105100A0 (en) Glutamic acid derivatives and process for their preparation
FI885692A0 (fi) Karboksimetyylisulfoetyyliselluloosa ja menetelmä sen valmistamiseksi
PT87550A (pt) Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same
PT85513A (en) Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same
EP0317175A3 (en) Pyrimidine derivatives
GB8827462D0 (en) Pyrimidine derivatives
MX9201540A (es) Derivados de amidina y proceso para su preparacion.
PT87743A (pt) Process for the preparation of pyrimidine derivatives and of insecticide and acaricide compounds which contain them
GB8902688D0 (en) Pyrimidine derivatives
FI95242B (fi) Menetelmä pyrrolijohdannaisten diesterien valmistamiseksi ja menetelmässä käyttökelpoiset välituotteet
HU9502077D0 (en) Aryl-carboxilic acid derivatives and process for their preparation
FI933004A (fi) Menetelmä N-alkyyli-3,4-dialkyylioksianiliinien ja niiden johdannaisten valmistamiseksi
FI953443A (fi) Menetelmä terapeuttisesti käyttökelpoisten 4-amino-3-isoksatsolidinonien ja 3-amino-1-hydroksipyrroilidin-2-onien karbamaattijohdannaisten valmistamiseksi
ZA885547B (en) Pyrimidine derivatives
GB8729583D0 (en) Pyrimidine derivatives

Legal Events

Date Code Title Description
FD Application lapsed