FI943934A - Menetelmä fibrinogeenireseptoriantagonisteina käyttökelpoisten 0-(4-(4-piperdinyyli)butyyli)tyrosiinijohdannaisten valmistamiseksi - Google Patents
Menetelmä fibrinogeenireseptoriantagonisteina käyttökelpoisten 0-(4-(4-piperdinyyli)butyyli)tyrosiinijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI943934A FI943934A FI943934A FI943934A FI943934A FI 943934 A FI943934 A FI 943934A FI 943934 A FI943934 A FI 943934A FI 943934 A FI943934 A FI 943934A FI 943934 A FI943934 A FI 943934A
- Authority
- FI
- Finland
- Prior art keywords
- piperidinyl
- butyl
- preparation
- receptor antagonists
- derivatives useful
- Prior art date
Links
- -1 4- (4-piperidinyl) butyl Chemical group 0.000 title 1
- 239000002319 fibrinogen receptor antagonist Substances 0.000 title 1
- 150000003667 tyrosine derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84369092A | 1992-02-28 | 1992-02-28 | |
| US84369092 | 1992-02-28 | ||
| PCT/US1993/001621 WO1993016994A1 (en) | 1992-02-28 | 1993-02-24 | Process for the preparation of 0-[4-(4-piperidinyl)butyl]-tyrosine derivatives as fibrinogen receptor antagonists |
| US9301621 | 1993-02-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI943934A0 FI943934A0 (fi) | 1994-08-26 |
| FI943934A true FI943934A (fi) | 1994-10-05 |
| FI106024B FI106024B (fi) | 2000-11-15 |
Family
ID=25290743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI943934A FI106024B (fi) | 1992-02-28 | 1994-08-26 | Menetelmä fibrinogeenireseptoriantagonisteina käyttökelpoisen N-(n-butyylisulfonyyli)-O-[4-(4 -piperidyyli)butyyli]tyrosiinin ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5312923A (fi) |
| CN (1) | CN1040534C (fi) |
| AU (1) | AU3731393A (fi) |
| CZ (1) | CZ282770B6 (fi) |
| FI (1) | FI106024B (fi) |
| HU (1) | HU223578B1 (fi) |
| RO (1) | RO115724B1 (fi) |
| RU (1) | RU2113432C1 (fi) |
| SK (1) | SK280164B6 (fi) |
| TW (1) | TW232008B (fi) |
| WO (1) | WO1993016994A1 (fi) |
| YU (1) | YU13293A (fi) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3719997A (en) | 1996-07-01 | 1998-01-21 | Eli Lilly And Company | Hypoglycemic and hypolipidemic compounds |
| US6623981B2 (en) * | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
| GB9812088D0 (en) * | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
| EP1100497B1 (en) * | 1998-07-31 | 2004-05-12 | Eli Lilly And Company | Heterocyclyl sulphonamide derivatives |
| US6518244B2 (en) | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
| CN102241622A (zh) * | 2010-05-13 | 2011-11-16 | 上海医药工业研究院 | 一种制备盐酸替罗非班的方法 |
| CN101870672B (zh) * | 2010-07-05 | 2011-08-24 | 武汉同源药业有限公司 | 一种化合物盐酸替罗非班的制备方法 |
| CN101898998B (zh) * | 2010-08-25 | 2012-09-19 | 武汉武药科技有限公司 | 一种盐酸替罗非班中间体的制备方法 |
| CN102875449B (zh) * | 2012-10-15 | 2014-08-06 | 天津南开允公医药科技有限公司 | 盐酸替罗非班异构体分离方法及d构型盐酸替罗非班定量方法 |
| CN103848775A (zh) * | 2012-11-29 | 2014-06-11 | 上海信谊药厂有限公司 | 制备盐酸替罗非班的方法 |
| CN109608387A (zh) * | 2019-01-02 | 2019-04-12 | 海门慧聚药业有限公司 | 盐酸替罗非班的制备 |
| CN111100066B (zh) * | 2019-11-29 | 2021-07-30 | 石药集团恩必普药业有限公司 | 一种盐酸替罗非班中间体及盐酸替罗非班的制备方法 |
| CN115181058B (zh) * | 2021-04-01 | 2024-06-11 | 武汉武药科技有限公司 | 组合物及其质量控制方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412138A (en) * | 1965-12-17 | 1968-11-19 | Ibm | Alkylation of tyrosine |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
-
1993
- 1993-02-16 US US08/017,922 patent/US5312923A/en not_active Expired - Fee Related
- 1993-02-20 TW TW082101201A patent/TW232008B/zh active
- 1993-02-24 RU RU94041212/04A patent/RU2113432C1/ru not_active IP Right Cessation
- 1993-02-24 HU HU9402462A patent/HU223578B1/hu not_active IP Right Cessation
- 1993-02-24 AU AU37313/93A patent/AU3731393A/en not_active Abandoned
- 1993-02-24 CZ CZ942056A patent/CZ282770B6/cs not_active IP Right Cessation
- 1993-02-24 SK SK1024-94A patent/SK280164B6/sk unknown
- 1993-02-24 RO RO94-01434A patent/RO115724B1/ro unknown
- 1993-02-24 WO PCT/US1993/001621 patent/WO1993016994A1/en active IP Right Grant
- 1993-02-25 YU YU13293A patent/YU13293A/sh unknown
- 1993-02-27 CN CN93102134A patent/CN1040534C/zh not_active Expired - Fee Related
-
1994
- 1994-08-26 FI FI943934A patent/FI106024B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| SK280164B6 (sk) | 1999-09-10 |
| CZ282770B6 (cs) | 1997-10-15 |
| CZ205694A3 (en) | 1995-10-18 |
| RO115724B1 (ro) | 2000-05-30 |
| YU13293A (sh) | 1997-07-31 |
| HU223578B1 (hu) | 2004-09-28 |
| HUT70545A (en) | 1995-10-30 |
| FI106024B (fi) | 2000-11-15 |
| CN1076442A (zh) | 1993-09-22 |
| RU94041212A (ru) | 1996-06-20 |
| RU2113432C1 (ru) | 1998-06-20 |
| CN1040534C (zh) | 1998-11-04 |
| AU3731393A (en) | 1993-09-13 |
| SK102494A3 (en) | 1995-04-12 |
| WO1993016994A1 (en) | 1993-09-02 |
| TW232008B (fi) | 1994-10-11 |
| FI943934A0 (fi) | 1994-08-26 |
| HU9402462D0 (en) | 1994-10-28 |
| US5312923A (en) | 1994-05-17 |
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