FI940810A - Substituerade bensensulfonylurinämnen och tiourinämnen, förfarande förframställning av dessa och användning av dessa som läkemedel - Google Patents

Substituerade bensensulfonylurinämnen och tiourinämnen, förfarande förframställning av dessa och användning av dessa som läkemedel Download PDF

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Publication number
FI940810A
FI940810A FI940810A FI940810A FI940810A FI 940810 A FI940810 A FI 940810A FI 940810 A FI940810 A FI 940810A FI 940810 A FI940810 A FI 940810A FI 940810 A FI940810 A FI 940810A
Authority
FI
Finland
Prior art keywords
alkyl
thioureas
hal
arrhythmias
drugs
Prior art date
Application number
FI940810A
Other languages
English (en)
Finnish (fi)
Other versions
FI114152B (sv
FI940810A0 (sv
Inventor
Heinrich Englert
Dieter Mania
Jens Hartung
Heinz Goegelein
Joachim Kaiser
Wolfgang Linz
David Wettlaufer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI940810A0 publication Critical patent/FI940810A0/sv
Publication of FI940810A publication Critical patent/FI940810A/sv
Application granted granted Critical
Publication of FI114152B publication Critical patent/FI114152B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI940810A 1993-02-23 1994-02-21 Förfarande för framställning av terapeutiskt användbara substituerade bensensulfonylurinämnen och tiourinämnen FI114152B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4305450 1993-02-23
DE4305450 1993-02-23

Publications (3)

Publication Number Publication Date
FI940810A0 FI940810A0 (sv) 1994-02-21
FI940810A true FI940810A (sv) 1994-08-24
FI114152B FI114152B (sv) 2004-08-31

Family

ID=6481073

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940810A FI114152B (sv) 1993-02-23 1994-02-21 Förfarande för framställning av terapeutiskt användbara substituerade bensensulfonylurinämnen och tiourinämnen

Country Status (18)

Country Link
US (6) US5574069A (sv)
EP (1) EP0612724B1 (sv)
JP (1) JP2778450B2 (sv)
AT (1) ATE146775T1 (sv)
AU (1) AU664940B2 (sv)
CA (1) CA2116165C (sv)
CY (1) CY2034A (sv)
DE (1) DE59401361D1 (sv)
DK (1) DK0612724T3 (sv)
ES (1) ES2098069T3 (sv)
FI (1) FI114152B (sv)
GR (1) GR3022550T3 (sv)
HK (1) HK1006166A1 (sv)
HU (1) HU219639B (sv)
NO (1) NO300173B1 (sv)
NZ (1) NZ250925A (sv)
PL (2) PL175795B1 (sv)
TW (1) TW429245B (sv)

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DK0612724T3 (da) 1993-02-23 1997-06-16 Hoechst Ag Substituerede benzensulfonylurinstoffer og -thiourinstoffer, fremgangsmåde til deres fremstilling og deres anvendelse som farmaceutika
DE19503136A1 (de) * 1995-02-01 1996-08-08 Hoechst Ag Substituierte Thiophenylsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19504379A1 (de) * 1995-02-10 1996-08-14 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate sowie sie enthaltende pharmazeutische Präparate
HU226462B1 (en) * 1995-02-17 2008-12-29 Hoechst Ag Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use
DE19505397A1 (de) * 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ZA961314B (en) * 1995-02-21 1996-08-27 Hoechst Ag Substituted benzenesulfonylureas and -thioreas processes for their preparation their use for the production of pharmaceutical preparations and medicaments containing them
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19832009A1 (de) * 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
CN1195524C (zh) * 1998-09-10 2005-04-06 阿文蒂斯药物德国有限公司 苯磺酰(硫)脲与β－受体阻滞剂联合在制备用于心脏迷走神经机能障碍治疗和预防的药物中的用途
DE19917233A1 (de) * 1999-04-16 2000-10-19 Aventis Pharma Gmbh Kristalline Formen des Natriumsalzes des 5-Chlor-2-methoxy-N-(2-(4-methoxy-3-methylaminothiocarbonylaminosulfonyl-phenyl)-ethyl)- benzamids
DE19923086A1 (de) * 1999-05-20 2000-11-23 Aventis Pharma Gmbh Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE60143047D1 (de) 2000-10-17 2010-10-21 Asahi Chemical Ind Verfahren zur herstellung einer polyisocyanat-zusammensetzung
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US8472428B2 (en) 2001-02-27 2013-06-25 Verizon Data Services Llc Methods and systems for line management
DE10129704A1 (de) * 2001-06-22 2003-01-02 Aventis Pharma Gmbh Verwendung von Benzolsulfonyl(thio)harnstoffen in der Behandlung des septischen Schocks
US6835853B2 (en) * 2001-10-31 2004-12-28 Synthon Bv Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
DE102004061017A1 (de) * 2004-12-18 2006-06-22 Sanofi-Aventis Deutschland Gmbh Piperidinsulfonylharnstoffe und -thioharnstoffe, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
WO2007131804A1 (en) 2006-05-17 2007-11-22 Synthon B.V. Tablet composition with a prolonged release of tamsulosin
AU2007254179B2 (en) 2006-05-18 2013-03-21 Pharmacyclics Llc Intracellular kinase inhibitors
MX2009012644A (es) * 2007-06-05 2009-12-10 Sanofi Aventis Derivados de di(hetero)arilciclohexano, su preparacion, su uso y composiciones farmaceuticas que los comprenden.
US8465770B2 (en) * 2008-12-24 2013-06-18 Synthon Bv Low dose controlled release tablet
WO2010148177A2 (en) * 2009-06-17 2010-12-23 The Board Of Trustees Of The Leland Stanford Junior University Compounds, compositions, methods of synthesis, and methods of treatment

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Also Published As

Publication number Publication date
NZ250925A (en) 1995-09-26
US6335467B1 (en) 2002-01-01
CY2034A (en) 1998-02-20
US6090981A (en) 2000-07-18
US20020058838A1 (en) 2002-05-16
HUT71104A (en) 1995-11-28
EP0612724B1 (de) 1996-12-27
EP0612724A1 (de) 1994-08-31
GR3022550T3 (en) 1997-05-31
ATE146775T1 (de) 1997-01-15
US6506937B2 (en) 2003-01-14
HU9400525D0 (en) 1994-05-30
NO940600L (no) 1994-08-24
PL175795B1 (pl) 1999-02-26
FI114152B (sv) 2004-08-31
NO300173B1 (no) 1997-04-21
ES2098069T3 (es) 1997-04-16
PL179268B1 (pl) 2000-08-31
JP2778450B2 (ja) 1998-07-23
PL302325A1 (en) 1994-09-05
NO940600D0 (no) 1994-02-22
US5574069A (en) 1996-11-12
AU5527994A (en) 1994-09-01
AU664940B2 (en) 1995-12-07
CA2116165A1 (en) 1994-08-24
CA2116165C (en) 2006-02-21
DK0612724T3 (da) 1997-06-16
DE59401361D1 (de) 1997-02-06
US5776980A (en) 1998-07-07
FI940810A0 (sv) 1994-02-21
HK1006166A1 (en) 1999-02-12
TW429245B (en) 2001-04-11
HU219639B (hu) 2001-06-28
US5698596A (en) 1997-12-16
JPH07304728A (ja) 1995-11-21

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Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH

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