FI935298A0 - Anvaendning av rapamycin prolaekemedel som immunosuppressiva medel - Google Patents
Anvaendning av rapamycin prolaekemedel som immunosuppressiva medelInfo
- Publication number
- FI935298A0 FI935298A0 FI935298A FI935298A FI935298A0 FI 935298 A0 FI935298 A0 FI 935298A0 FI 935298 A FI935298 A FI 935298A FI 935298 A FI935298 A FI 935298A FI 935298 A0 FI935298 A0 FI 935298A0
- Authority
- FI
- Finland
- Prior art keywords
- rapamycin
- immunosuppressive agents
- immunosuppressive
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70841291A | 1991-05-31 | 1991-05-31 | |
PCT/US1992/002504 WO1992021341A1 (en) | 1991-05-31 | 1992-04-03 | Use of rapamycin prodrugs as immunosuppressant agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FI935298A FI935298A (fi) | 1993-11-29 |
FI935298A0 true FI935298A0 (fi) | 1993-11-29 |
Family
ID=24845706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI935298A FI935298A0 (fi) | 1991-05-31 | 1993-11-29 | Anvaendning av rapamycin prolaekemedel som immunosuppressiva medel |
Country Status (8)
Country | Link |
---|---|
US (1) | US5432183A (fi) |
EP (1) | EP0586512A1 (fi) |
JP (1) | JPH06502659A (fi) |
CA (1) | CA2102116A1 (fi) |
FI (1) | FI935298A0 (fi) |
IE (1) | IE921728A1 (fi) |
PT (1) | PT100556A (fi) |
WO (1) | WO1992021341A1 (fi) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5432183A (en) * | 1991-05-31 | 1995-07-11 | Pfizer Inc. | Use of rapamycin prodrugs as immunosuppressant agents |
ES2258763T3 (es) * | 1992-10-13 | 2006-09-01 | Wyeth | Carbamatos de rapamicina. |
US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US5310903A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
US5310901A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives |
US5504091A (en) * | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
US5387680A (en) * | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
WO1995014023A1 (en) * | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
WO2001012633A1 (en) * | 1999-08-18 | 2001-02-22 | American Home Products Corporation | Water soluble sdz-rad esters |
EP1313740B1 (en) * | 2000-03-29 | 2005-11-30 | ALTANA Pharma AG | Prodrugs of imidazopyridine derivatives |
SK5072003A3 (en) * | 2000-10-25 | 2003-09-11 | Altana Pharma Ag | Polysubstituted imidazopyridines as gastric secretion inhibitors |
EP2147679B1 (en) | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Compositions for blood-brain barrier transport |
JP2005532809A (ja) | 2002-07-16 | 2005-11-04 | バイオチカ テクノロジー リミテッド | ポリケチド、及び他の天然物の製造 |
US7160867B2 (en) | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
US7589233B2 (en) * | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
CA2534342C (en) * | 2003-07-29 | 2016-05-10 | V. Ravi Chandran | Amino acid prodrugs |
US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
US8021849B2 (en) * | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
WO2006096325A1 (en) | 2005-03-07 | 2006-09-14 | Wyeth | Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin |
GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
AU2006221774A1 (en) | 2005-03-11 | 2006-09-14 | Biotica Technology Limited | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
US7189582B2 (en) * | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
WO2006116718A2 (en) | 2005-04-28 | 2006-11-02 | Proteus Biomedical, Inc. | Pharma-informatics system |
AU2006315638B2 (en) | 2005-11-11 | 2013-02-21 | V. Ravi Chandran | Acetylated amino acids as anti-platelet agents, nutritional and vitamin supplements |
GB0609963D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
GB0609962D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
US8795627B2 (en) | 2007-03-21 | 2014-08-05 | Raptor Pharmaceuticals Inc. | Treatment of liver disorders by administration of RAP conjugates |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
WO2009131631A1 (en) * | 2008-04-14 | 2009-10-29 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
CN102458374A (zh) | 2009-05-06 | 2012-05-16 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
EP3576736A4 (en) | 2017-02-10 | 2020-08-26 | Torcept Therapeutics Inc. | RAPAMYCIN ANALOGUE |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5200411A (en) * | 1989-06-14 | 1993-04-06 | Sandoz, Ltd. | Heteroatoms-containing tricyclic compounds |
GB2244991A (en) * | 1990-06-11 | 1991-12-18 | Fujisawa Pharmaceutical Co | Tricyclo compounds |
US5432183A (en) * | 1991-05-31 | 1995-07-11 | Pfizer Inc. | Use of rapamycin prodrugs as immunosuppressant agents |
-
1992
- 1992-04-03 US US08/142,422 patent/US5432183A/en not_active Expired - Fee Related
- 1992-04-03 EP EP92912028A patent/EP0586512A1/en not_active Withdrawn
- 1992-04-03 JP JP5500386A patent/JPH06502659A/ja active Pending
- 1992-04-03 WO PCT/US1992/002504 patent/WO1992021341A1/en not_active Application Discontinuation
- 1992-04-03 CA CA002102116A patent/CA2102116A1/en not_active Abandoned
- 1992-05-29 PT PT100556A patent/PT100556A/pt not_active Application Discontinuation
- 1992-07-01 IE IE172892A patent/IE921728A1/en not_active Application Discontinuation
-
1993
- 1993-11-29 FI FI935298A patent/FI935298A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
US5432183A (en) | 1995-07-11 |
FI935298A (fi) | 1993-11-29 |
WO1992021341A1 (en) | 1992-12-10 |
CA2102116A1 (en) | 1992-12-01 |
JPH06502659A (ja) | 1994-03-24 |
PT100556A (pt) | 1993-09-30 |
IE921728A1 (en) | 1992-12-02 |
EP0586512A1 (en) | 1994-03-16 |
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