FI933656A0 - 2,4-diaminokinazolinderivat, som foerstaerker antitumoeraktivitet - Google Patents
2,4-diaminokinazolinderivat, som foerstaerker antitumoeraktivitetInfo
- Publication number
- FI933656A0 FI933656A0 FI933656A FI933656A FI933656A0 FI 933656 A0 FI933656 A0 FI 933656A0 FI 933656 A FI933656 A FI 933656A FI 933656 A FI933656 A FI 933656A FI 933656 A0 FI933656 A0 FI 933656A0
- Authority
- FI
- Finland
- Prior art keywords
- derivatives
- foerstaerker
- diaminoquinazole
- antitumoeractives
- som
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65792291A | 1991-02-20 | 1991-02-20 | |
PCT/US1992/000028 WO1992014716A1 (en) | 1991-02-20 | 1992-01-08 | 2,4-diaminoquinazolines derivatives for enhancing antitumor activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FI933656A FI933656A (fi) | 1993-08-19 |
FI933656A0 true FI933656A0 (fi) | 1993-08-19 |
Family
ID=24639196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI933656A FI933656A0 (fi) | 1991-02-20 | 1993-08-19 | 2,4-diaminokinazolinderivat, som foerstaerker antitumoeraktivitet |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0572437B1 (no) |
JP (1) | JPH06500117A (no) |
KR (1) | KR930703270A (no) |
CN (1) | CN1064271A (no) |
AT (1) | ATE121735T1 (no) |
AU (1) | AU655798B2 (no) |
BR (1) | BR9205645A (no) |
CA (1) | CA2101542A1 (no) |
CZ (1) | CZ387292A3 (no) |
DE (2) | DE69202243T2 (no) |
DK (1) | DK0572437T3 (no) |
ES (1) | ES2071484T3 (no) |
FI (1) | FI933656A0 (no) |
HU (1) | HUT64755A (no) |
IE (1) | IE920522A1 (no) |
IL (1) | IL100942A0 (no) |
MX (1) | MX9200675A (no) |
NO (1) | NO932954L (no) |
NZ (1) | NZ241627A (no) |
PT (1) | PT100132A (no) |
WO (1) | WO1992014716A1 (no) |
YU (1) | YU17092A (no) |
ZA (1) | ZA921911B (no) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
ES2049659B1 (es) * | 1992-10-08 | 1994-10-16 | Ici Plc | Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena. |
GB9323290D0 (en) * | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
GB9314893D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
DE4429026C2 (de) * | 1994-08-16 | 1995-11-16 | Mueller Wolfgang | Inlay-Entfernungsinstrumentarium für Totalendoprothese |
GB9424233D0 (en) * | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
US5932574A (en) * | 1995-04-27 | 1999-08-03 | Zeneca Limited | Quinazoline derivatives |
GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
WO1997020822A1 (en) * | 1995-12-01 | 1997-06-12 | Novartis Ag | Quinazolin-2,4-diazirines as npy receptor antagonist |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab, Soedertaelje | 4-anilinochinazolin derivate |
GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
EE05330B1 (et) | 1999-11-05 | 2010-08-16 | Astrazeneca Ab | Kinasoliini derivaadid kui VEGF-i inhibiitorid |
WO2001068615A1 (en) * | 2000-03-13 | 2001-09-20 | Chemrx Advanced Technologies, Inc. | Quinazoline synthesis |
NZ521421A (en) | 2000-04-07 | 2004-09-24 | Astrazeneca Ab | Quinazoline compounds |
WO2003055866A1 (en) * | 2001-12-21 | 2003-07-10 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
WO2006074147A2 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
JP2007269629A (ja) * | 2004-06-21 | 2007-10-18 | Astellas Pharma Inc | キナゾリン誘導体 |
JP2008505907A (ja) * | 2004-07-06 | 2008-02-28 | アンジオン バイオメディカ コーポレイション | 癌治療を目的として肝細胞増殖因子およびc−met活性を調整するキナゾリンモジュレーター |
CN101287369A (zh) * | 2005-01-03 | 2008-10-15 | 美瑞德生物工程公司 | 治疗脑癌的方法 |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
EP1963284A1 (en) * | 2005-12-07 | 2008-09-03 | NeuroSearch A/S | Novel quinazoline-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
CN101100466B (zh) | 2006-07-05 | 2013-12-25 | 天津和美生物技术有限公司 | 不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用 |
US20090004185A1 (en) * | 2007-01-11 | 2009-01-01 | Wyeth | Amino-substituted quinazoline derivatives as inhibitors of beta-catenin/tcf-4 pathway and cancer treatment agents |
CA2691932A1 (en) * | 2007-06-27 | 2008-12-31 | Summit Corporation Plc | Use of compounds for preparing anti-tuberculosis agents |
WO2011140527A2 (en) * | 2010-05-07 | 2011-11-10 | California Institute Of Technology And The University Of Kansas | Methods and compositions for inhibition of the transitional endoplasmic reticulum atpase |
WO2018212774A1 (en) * | 2017-05-17 | 2018-11-22 | Vanderbilt University | Quinazoline compounds as modulators of ras signaling |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3635979A (en) * | 1969-09-29 | 1972-01-18 | Pfizer | Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines |
AU610328B2 (en) * | 1987-12-03 | 1991-05-16 | Smithkline Beckman Intercredit B.V. | 2,4- diaminoquinazoline derivatives |
IL88507A (en) * | 1987-12-03 | 1993-02-21 | Smithkline Beckman Intercredit | 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them |
-
1992
- 1992-01-08 AT AT92903632T patent/ATE121735T1/de not_active IP Right Cessation
- 1992-01-08 BR BR9205645A patent/BR9205645A/pt not_active Application Discontinuation
- 1992-01-08 CA CA002101542A patent/CA2101542A1/en not_active Abandoned
- 1992-01-08 JP JP4503777A patent/JPH06500117A/ja active Pending
- 1992-01-08 ES ES92903632T patent/ES2071484T3/es not_active Expired - Lifetime
- 1992-01-08 HU HU9302384A patent/HUT64755A/hu unknown
- 1992-01-08 DE DE69202243T patent/DE69202243T2/de not_active Expired - Fee Related
- 1992-01-08 WO PCT/US1992/000028 patent/WO1992014716A1/en active IP Right Grant
- 1992-01-08 DE DE9290018U patent/DE9290018U1/de not_active Expired - Lifetime
- 1992-01-08 KR KR1019930702481A patent/KR930703270A/ko not_active Application Discontinuation
- 1992-01-08 AU AU11848/92A patent/AU655798B2/en not_active Expired - Fee Related
- 1992-01-08 EP EP92903632A patent/EP0572437B1/en not_active Expired - Lifetime
- 1992-01-08 DK DK92903632.5T patent/DK0572437T3/da active
- 1992-01-08 CZ CS923872A patent/CZ387292A3/cs unknown
- 1992-02-13 IL IL100942A patent/IL100942A0/xx unknown
- 1992-02-17 NZ NZ241627A patent/NZ241627A/xx unknown
- 1992-02-18 MX MX9200675A patent/MX9200675A/es unknown
- 1992-02-18 PT PT100132A patent/PT100132A/pt not_active Application Discontinuation
- 1992-02-19 CN CN92101113A patent/CN1064271A/zh active Pending
- 1992-02-19 YU YU17092A patent/YU17092A/sh unknown
- 1992-02-19 ZA ZA921191A patent/ZA921911B/xx unknown
- 1992-02-19 IE IE052292A patent/IE920522A1/en not_active Application Discontinuation
-
1993
- 1993-08-19 NO NO93932954A patent/NO932954L/no unknown
- 1993-08-19 FI FI933656A patent/FI933656A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1064271A (zh) | 1992-09-09 |
IL100942A0 (en) | 1992-11-15 |
FI933656A (fi) | 1993-08-19 |
EP0572437B1 (en) | 1995-04-26 |
BR9205645A (pt) | 1994-06-07 |
ES2071484T3 (es) | 1995-06-16 |
KR930703270A (ko) | 1993-11-29 |
DK0572437T3 (da) | 1995-07-03 |
EP0572437A1 (en) | 1993-12-08 |
ZA921911B (en) | 1993-08-19 |
WO1992014716A1 (en) | 1992-09-03 |
HU9302384D0 (en) | 1993-11-29 |
DE9290018U1 (de) | 1993-10-14 |
ATE121735T1 (de) | 1995-05-15 |
PT100132A (pt) | 1993-05-31 |
DE69202243D1 (de) | 1995-06-01 |
AU655798B2 (en) | 1995-01-12 |
CA2101542A1 (en) | 1992-08-21 |
NZ241627A (en) | 1993-06-25 |
JPH06500117A (ja) | 1994-01-06 |
NO932954D0 (no) | 1993-08-19 |
NO932954L (no) | 1993-08-19 |
IE920522A1 (en) | 1992-08-26 |
MX9200675A (es) | 1992-08-01 |
DE69202243T2 (de) | 1995-08-31 |
YU17092A (sh) | 1994-12-28 |
AU1184892A (en) | 1992-09-15 |
HUT64755A (en) | 1994-02-28 |
CZ387292A3 (en) | 1994-04-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |