FI930552A7 - Nytt förfarande för framställning av nukleotider - Google Patents

Nytt förfarande för framställning av nukleotider Download PDF

Info

Publication number
FI930552A7
FI930552A7 FI930552A FI930552A FI930552A7 FI 930552 A7 FI930552 A7 FI 930552A7 FI 930552 A FI930552 A FI 930552A FI 930552 A FI930552 A FI 930552A FI 930552 A7 FI930552 A7 FI 930552A7
Authority
FI
Finland
Prior art keywords
new method
producing nucleotides
nucleotides
producing
new
Prior art date
Application number
FI930552A
Other languages
English (en)
Finnish (fi)
Other versions
FI930552A0 (fi
FI930552L (fi
Inventor
Paul R Brodfuehrer
Jr Chester Sapino
Henry G Howell
Purushotham Vemishetti
Original Assignee
Rega Stichting
Inst Of Organic Chemistry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rega Stichting, Inst Of Organic Chemistry filed Critical Rega Stichting
Publication of FI930552A0 publication Critical patent/FI930552A0/fi
Publication of FI930552L publication Critical patent/FI930552L/fi
Publication of FI930552A7 publication Critical patent/FI930552A7/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI930552A 1990-08-10 1991-08-06 Nytt förfarande för framställning av nukleotider FI930552A7 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56620090A 1990-08-10 1990-08-10
PCT/US1991/005578 WO1992002511A1 (en) 1990-08-10 1991-08-06 Novel process for the preparation of nucleotides

Publications (3)

Publication Number Publication Date
FI930552A0 FI930552A0 (fi) 1993-02-09
FI930552L FI930552L (fi) 1993-02-22
FI930552A7 true FI930552A7 (sv) 1993-02-22

Family

ID=24261919

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930552A FI930552A7 (sv) 1990-08-10 1991-08-06 Nytt förfarande för framställning av nukleotider

Country Status (11)

Country Link
US (2) US5476938A (sv)
EP (1) EP0574386B1 (sv)
JP (1) JP3116079B2 (sv)
KR (1) KR100221981B1 (sv)
AT (1) ATE194142T1 (sv)
AU (1) AU653552B2 (sv)
CA (1) CA2088363C (sv)
DE (1) DE69132276T2 (sv)
ES (1) ES2149157T3 (sv)
FI (1) FI930552A7 (sv)
WO (1) WO1992002511A1 (sv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
ES2149157T3 (es) * 1990-08-10 2000-11-01 Acad Of Science Czech Republic Nuevo procedimiento para la preparacion de nucleotidos.
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US6448373B1 (en) * 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
AU2001282941C1 (en) 2000-07-21 2016-12-22 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
JP4996241B2 (ja) 2003-01-14 2012-08-08 ギリアード サイエンシーズ， インコーポレイテッド 組み合わせ抗ウイルス治療のための組成物および方法
WO2005012324A2 (en) * 2003-07-30 2005-02-10 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP2161023A3 (en) 2007-04-13 2010-12-29 Southern Research Institute Anti-angiogenic agents and methods of use.
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
ES2629165T3 (es) 2010-02-12 2017-08-07 Chimerix, Inc. Métodos de tratamiento de una infección vírica
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
EP2611818B1 (en) * 2010-08-31 2016-08-24 Chimerix, Inc. Phosphonate ester derivatives and methods of synthesis thereof
CN104666315A (zh) 2010-12-10 2015-06-03 西格玛制药实验有限责任公司 口服活性核苷酸类似物或口服活性核苷酸类似物前药的高度稳定组合物
DK2794624T3 (da) 2011-12-22 2019-07-22 Geron Corp Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
CN105899215A (zh) * 2013-11-15 2016-08-24 奇默里克斯公司 十六烷氧基丙基膦酸酯的形态
CN103951703A (zh) * 2014-04-28 2014-07-30 中国人民解放军军事医学科学院微生物流行病研究所 制备膦酯衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
DE3585643D1 (de) * 1984-07-03 1992-04-23 Wellcome Found Antiviren-verbindungen, behandlung und formulierungen.
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
IL82998A0 (en) * 1986-07-07 1987-12-20 Koller Werner Dental sleeve,its production and its use for producing a ceramic crown
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
ES2149157T3 (es) * 1990-08-10 2000-11-01 Acad Of Science Czech Republic Nuevo procedimiento para la preparacion de nucleotidos.

Also Published As

Publication number Publication date
EP0574386B1 (en) 2000-06-28
AU653552B2 (en) 1994-10-06
EP0574386A4 (en) 1993-10-27
AU8492891A (en) 1992-03-02
FI930552A0 (fi) 1993-02-09
CA2088363A1 (en) 1992-02-11
ES2149157T3 (es) 2000-11-01
DE69132276T2 (de) 2001-03-01
JP3116079B2 (ja) 2000-12-11
FI930552L (fi) 1993-02-22
DE69132276D1 (de) 2000-08-03
KR100221981B1 (ko) 1999-09-15
ATE194142T1 (de) 2000-07-15
US5476938A (en) 1995-12-19
WO1992002511A1 (en) 1992-02-20
KR930702349A (ko) 1993-09-08
US5591852A (en) 1997-01-07
JPH06503807A (ja) 1994-04-28
EP0574386A1 (en) 1993-12-22
CA2088363C (en) 2002-05-28

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