FI922851A - Matrix containing adherent bound cells and method for producing virus / viral antigen - Google Patents

Matrix containing adherent bound cells and method for producing virus / viral antigen Download PDF

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Publication number
FI922851A
FI922851A FI922851A FI922851A FI922851A FI 922851 A FI922851 A FI 922851A FI 922851 A FI922851 A FI 922851A FI 922851 A FI922851 A FI 922851A FI 922851 A FI922851 A FI 922851A
Authority
FI
Finland
Prior art keywords
virus
bound
cells
fsme
antigens
Prior art date
Application number
FI922851A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI98377C (en
FI922851A0 (en
FI98377B (en
Inventor
Wolfgang Mundt
Noel Barrett
Friedrich Dorner
Johann Eibl
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno Ag filed Critical Immuno Ag
Publication of FI922851A publication Critical patent/FI922851A/en
Publication of FI922851A0 publication Critical patent/FI922851A0/en
Application granted granted Critical
Publication of FI98377B publication Critical patent/FI98377B/en
Publication of FI98377C publication Critical patent/FI98377C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A matrix or substrate bears adherently bound human or animal cells infected with a virus. It has been shown that surface dependent cells useful for virus multiplication remain adherently bound to a matrix even when infected with a virus, produce virus antigens over a relatively long period of time and release them in the culture medium. In order to produce early Summer meningo-encephalitis (FSME) virus antigens by cultivating the FSME virus in cell cultures, a surface dependent permanent cell line, preferably the vero-cell line ATTC CCL 81, is inoculated with the FSME virus and the cells are bound to substrates and kept in a non lytic serum free system in conditions that ensure cellular growth, so that antigens are produced. The antigen-containing medium is then separated from the substrate bound cells and processed in a known manner by concentration, inactivation and purification until a galenically acceptable composition is obtained.
FI922851A 1989-12-22 1992-06-18 Matrix containing adherent bound cells and method for producing virus / viral antigen FI98377C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT2928/89A AT393356B (en) 1989-12-22 1989-12-22 METHOD FOR PRODUCING TBE VIRUS ANTIGES
AT292889 1989-12-22
PCT/AT1990/000128 WO1991009935A1 (en) 1989-12-22 1990-12-21 Matrix with adherently bound cells and process for producing viruses/virus antigens
AT9000128 1990-12-21

Publications (4)

Publication Number Publication Date
FI922851A true FI922851A (en) 1992-06-18
FI922851A0 FI922851A0 (en) 1992-06-18
FI98377B FI98377B (en) 1997-02-28
FI98377C FI98377C (en) 1997-06-10

Family

ID=3542524

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922851A FI98377C (en) 1989-12-22 1992-06-18 Matrix containing adherent bound cells and method for producing virus / viral antigen

Country Status (16)

Country Link
EP (1) EP0506714B1 (en)
JP (1) JP2633391B2 (en)
AT (2) AT393356B (en)
CA (1) CA2071954C (en)
CZ (1) CZ281804B6 (en)
DE (1) DE59007659D1 (en)
DK (1) DK0506714T3 (en)
ES (1) ES2067916T3 (en)
FI (1) FI98377C (en)
HR (1) HRP921354A2 (en)
HU (1) HU213886B (en)
NO (1) NO310305B1 (en)
RU (1) RU2082757C1 (en)
SK (1) SK659090A3 (en)
WO (1) WO1991009935A1 (en)
YU (1) YU242390A (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3158157B2 (en) * 1994-11-10 2001-04-23 バクスター・アクチエンゲゼルシャフト Biopharmaceutical production in protein-free culture
AU709584B2 (en) * 1995-08-01 1999-09-02 Pasteur Merieux Serums Et Vaccins Industrial production process for a vaccine against Japanese encephalitis, and vaccine obtained
FR2737412B1 (en) * 1995-08-01 1997-10-24 Pasteur Merieux Serums Vacc PROCESS FOR PRODUCING A VACCINE AGAINST JAPANESE ENCEPHALITIS VIRUS AND VACCINE OBTAINED THEREBY
AU743546B2 (en) * 1998-10-05 2002-01-31 Research Foundation For Microbial Diseases Of Osaka University, The Enhanced immunogen for inactivated vaccine for infection with Japanese encephalitis viruses and process for producing the same
AT409379B (en) 1999-06-02 2002-07-25 Baxter Ag MEDIUM FOR PROTEIN- AND SERUM-FREE CELL CULTURE
US6855535B2 (en) * 2001-12-10 2005-02-15 Baxter Healthcare S.A. Method of large scale production of Hepatitis A virus
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
JP2007068401A (en) * 2003-08-07 2007-03-22 Chemo Sero Therapeut Res Inst West nile virus vaccine
PT2235197T (en) * 2007-12-27 2017-10-11 Baxalta Inc Cell culture processes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT358167B (en) * 1978-12-22 1980-08-25 Immuno Ag METHOD FOR PRODUCING EARLY SUMMER MENINGOENZEPHALITIS VIRUS (FSME VIRUS) VACCINES
SE445116B (en) * 1979-09-12 1986-06-02 Pharmacia Fine Chemicals Ab MAKE CULTURE CELLS ON MICROBATORS WITH FIBRONECTINE LAYERS
NO161446C (en) * 1981-03-13 1989-08-16 Damon Biotech Inc PROCEDURE FOR CULTING CELLS RELATED TO ANCHORING.
SE8103138L (en) * 1981-05-19 1982-11-20 Pharmacia Fine Chemicals Ab MICROBATCHERS FOR CULTURE OF ANCHORING-DEPENDENT CELLS
CA1206900A (en) * 1981-12-21 1986-07-02 Raymond L. Downs Hollow glass shell microcarrier for growth of cell cultures, and method of shell manufacture
AT385203B (en) * 1985-04-26 1988-03-10 Immuno Ag METHOD FOR PRODUCING AN EARLY SUMMER MENINGOCEPHALITIS VIRUS (TBE VIRUS) VACCINE
DD274336A3 (en) * 1985-10-03 1989-12-20 Npo Biolar Process for obtaining a microcarrier substance for cell cultivation

Also Published As

Publication number Publication date
HRP921354A2 (en) 1996-02-29
CZ281804B6 (en) 1997-02-12
HU213886B (en) 1997-11-28
NO922422D0 (en) 1992-06-19
SK279236B6 (en) 1998-08-05
EP0506714A1 (en) 1992-10-07
WO1991009935A1 (en) 1991-07-11
HUT65410A (en) 1994-06-28
JP2633391B2 (en) 1997-07-23
FI98377C (en) 1997-06-10
CZ659090A3 (en) 1996-11-13
DE59007659D1 (en) 1994-12-08
YU242390A (en) 1993-05-28
JPH05502581A (en) 1993-05-13
FI922851A0 (en) 1992-06-18
DK0506714T3 (en) 1995-04-18
HU9202009D0 (en) 1992-10-28
ATE113652T1 (en) 1994-11-15
CA2071954A1 (en) 1991-06-23
SK659090A3 (en) 1998-08-05
FI98377B (en) 1997-02-28
NO922422L (en) 1992-08-17
EP0506714B1 (en) 1994-11-02
RU2082757C1 (en) 1997-06-27
CA2071954C (en) 1996-06-18
ES2067916T3 (en) 1995-04-01
NO310305B1 (en) 2001-06-18
ATA292889A (en) 1991-03-15
AT393356B (en) 1991-10-10

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