FI921595A7 - Rapamysiinikarbamaatteja - Google Patents

Rapamysiinikarbamaatteja Download PDF

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Publication number
FI921595A7
FI921595A7 FI921595A FI921595A FI921595A7 FI 921595 A7 FI921595 A7 FI 921595A7 FI 921595 A FI921595 A FI 921595A FI 921595 A FI921595 A FI 921595A FI 921595 A7 FI921595 A7 FI 921595A7
Authority
FI
Finland
Prior art keywords
rapamycin
carbamates
rapamycin carbamates
Prior art date
Application number
FI921595A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI921595A0 (fi
FI921595L (fi
Inventor
Wenling Kao
John Henry Musser
Robert Lewis Vogel
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/686,728 external-priority patent/US5118678A/en
Priority claimed from US07/837,048 external-priority patent/US5194447A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of FI921595A0 publication Critical patent/FI921595A0/fi
Publication of FI921595L publication Critical patent/FI921595L/fi
Publication of FI921595A7 publication Critical patent/FI921595A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI921595A 1991-04-17 1992-04-10 Rapamysiinikarbamaatteja FI921595A7 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/686,728 US5118678A (en) 1991-04-17 1991-04-17 Carbamates of rapamycin
US07/837,048 US5194447A (en) 1992-02-18 1992-02-18 Sulfonylcarbamates of rapamycin

Publications (3)

Publication Number Publication Date
FI921595A0 FI921595A0 (fi) 1992-04-10
FI921595L FI921595L (fi) 1992-10-18
FI921595A7 true FI921595A7 (fi) 1992-10-18

Family

ID=27103855

Family Applications (1)

Application Number Title Priority Date Filing Date
FI921595A FI921595A7 (fi) 1991-04-17 1992-04-10 Rapamysiinikarbamaatteja

Country Status (12)

Country Link
EP (1) EP0509795A2 (OSRAM)
JP (1) JPH05112573A (OSRAM)
KR (1) KR920019798A (OSRAM)
AU (1) AU642592B2 (OSRAM)
CZ (1) CZ117392A3 (OSRAM)
FI (1) FI921595A7 (OSRAM)
HU (1) HU9201254D0 (OSRAM)
IE (1) IE921249A1 (OSRAM)
MX (1) MX9201710A (OSRAM)
NO (1) NO921449L (OSRAM)
NZ (1) NZ242367A (OSRAM)
SK (1) SK117392A3 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776943A (en) * 1991-05-14 1998-07-07 American Home Products Corporation Rapamycin metabolites
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
MX9301188A (es) * 1992-03-05 1994-07-29 American Home Prod Nuevos sulfonatos y 42-(n-carboalcoxi)sulfamatos en posicion 42 de la rapamicina, procedimiento para su preparacion y composicion farmaceutica que los comprende.
GB9307491D0 (en) * 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
ATE538794T1 (de) 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1210350B1 (en) * 1999-08-18 2004-07-14 Wyeth Water soluble sdz-rad esters
SI1478358T1 (sl) 2002-02-11 2013-09-30 Bayer Healthcare Llc Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
EP1626714B1 (en) 2003-05-20 2007-07-04 Bayer Pharmaceuticals Corporation Diaryl ureas for diseases mediated by pdgfr
EP1663978B1 (en) 2003-07-23 2007-11-28 Bayer Pharmaceuticals Corporation Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
CA2544731A1 (en) 2003-11-03 2005-05-12 Altachem Pharma Ltd. Rapamycin peptides conjugates: synthesis and uses thereof
US8021849B2 (en) 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
CA2602010A1 (en) 2005-03-07 2006-09-14 Wyeth Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
SG11202107653RA (en) * 2019-01-25 2021-08-30 Nodthera Ltd Carbamate derivatives and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885171A (en) * 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
US4316885A (en) * 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
EP0487593A1 (en) * 1989-08-18 1992-06-03 FISONS plc Macrocyclic compounds
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin

Also Published As

Publication number Publication date
EP0509795A3 (OSRAM) 1994-03-23
KR920019798A (ko) 1992-11-20
FI921595A0 (fi) 1992-04-10
AU1488092A (en) 1992-10-22
NO921449L (no) 1992-10-19
JPH05112573A (ja) 1993-05-07
HU9201254D0 (en) 1992-07-28
FI921595L (fi) 1992-10-18
SK117392A3 (en) 1995-04-12
IE921249A1 (en) 1992-10-21
NZ242367A (en) 1994-07-26
CZ117392A3 (en) 1993-09-15
NO921449D0 (no) 1992-04-10
MX9201710A (es) 1993-01-01
EP0509795A2 (en) 1992-10-21
AU642592B2 (en) 1993-10-21

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