FI91075B - Förfarande för framställning av nya terapeutiskt användbara peptider - Google Patents

Förfarande för framställning av nya terapeutiskt användbara peptider Download PDF

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Publication number
FI91075B
FI91075B FI883388A FI883388A FI91075B FI 91075 B FI91075 B FI 91075B FI 883388 A FI883388 A FI 883388A FI 883388 A FI883388 A FI 883388A FI 91075 B FI91075 B FI 91075B
Authority
FI
Finland
Prior art keywords
phe
peptide
nal
pro
cit
Prior art date
Application number
FI883388A
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English (en)
Finnish (fi)
Other versions
FI883388A (sv
FI91075C (sv
FI883388A0 (sv
Inventor
Andrew V Schally
Sandor Bajusz
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of FI883388A0 publication Critical patent/FI883388A0/sv
Publication of FI883388A publication Critical patent/FI883388A/sv
Priority to FI933629A priority Critical patent/FI101884B/sv
Application granted granted Critical
Publication of FI91075B publication Critical patent/FI91075B/sv
Publication of FI91075C publication Critical patent/FI91075C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/11—Gonadotropin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (7)

1. Förfarande för framställning av en terapeutiskt användbar peptid med formeln 5 X-R1-R2-R3-Ser-Tyr-R6-Leu-Arg-Pro-R10-NH2 (I) i vilken X är en acylgrupp, som har erh&llits frän ogrenade 10 eller grenade kedjor av alifatlska eller alicykliska kar-boxylsyror som innehäller 1-7 kolatomer, eller en kar-bamoylgrupp, R1 är D- eller L-Pro, D- eller L-A3-Pro, D-Phe, D-Phe(4-H1), D-Ser, D-Thr, D-Ala, D-Nal(l) eller 15 D-Nal(2), R2 är D-Phe eller D-Phe(4-Hl), R3 är D-Trp, D-Phe, D-Pal(3), D-Nal(l) eller D-Nal(2), R6 är D-Cit, D-Hci, D-Cit(Q) eller D-Hci(Q) och 20 R10 är Gly eller D-Ala, varvid Hl är fluor, klor eller brom och Q är C1.3-alkyl, eller för framställning av ett farmaceutiskt godtagbart syraadditionssalt därav, kännetecknat därav, att 25 motsvarande peptidfragment kondenseras med hjälp av 1 peptidkeml vanlig fragmentkondensation eller peptiden bildas gradvis av utgängsaminosyror med hjälp av i peptidkemi vanlig fragmentkondensation eller 1 peptiden med formeln I, i vilken R6 är D-Orn el-30 ler D-Lys, förvandlas den fria aminogruppen av D-Orn eller D-Lys genom att bringa den att reagera med alkalicya-nat eller med en förening som alstrar cyanat, eller med C1.3-alkyl-isocyanat tili en ureidogrupp och de erhällna peptiderna acyleras eventuellt och/el-i 35 ler förvandlas tili amider och II 91075 förvandlas eventuellt till fysiologiskt ofarliga syrasalt.
2. Förfarande enligt patentkrav 1, känne- t e c k n a t därav, att ett gradvist bildande utförs, 5 varvid aminosyran i karboxyländan, glysin eller D-alanin, eller en amid därav, i vilka den stabila a-aminogruppen har skyddats, binds först kovalent pä en för detta ända-mäl konventionell syntetisk bärare, skyddsgruppen i α-amino-gruppen spjälks av, pä den sä erhällna fria ami-10 nogruppen binds den närmast följande skyddade aminosyran via dess karboxylgrupp, därefter spjälks skyddsgruppen i a-amino i denna andra aminosyra av, pä denna binds den närmast följande aminosyran ooh pä detta sätt steg för steg kopplas de övriga aminosyrorna i peptiden som skall 15 syntetiseras i rätt ordning, och när alla aminosyror har kopplats, spjälks den färdiga peptiden frän bäraren och eventuellt spjälks även de närvarande skyddsgrupperna i sidogrupperna av.
3. Förfarande enligt patentkrav 1, känne-20 tecknat därav, att X är en acetyl- eller karba- moylgrupp, R1 är D-Nal(2), D- eller L-Pro, D-Phe eller D-Phe(4-C1), R2 är D-Phe(4-Cl) eller D-Phe(4-F) och R3 är D-Trp eller D-Pal(3).
4. Förfarande enligt nägot av patentkraven 1-3, 25 kännetecknat därav, att X är acetyl, R1 är D-Nal(2) eller D-Phe(4-Cl), R2 är D-Phe(4-Cl), R3 är D-Trp eller D-Pal(3) och R10 är D-Ala.
5. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att X är acetyl. 30
6. Förfarande enligt nägot av patentkraven 1-4, kännetecknat därav, att X är karbamoyl.
7. Förfarande enligt nägot av patentkraven 1-6, kännetecknat därav, att R6 är D-Cit eller D-Hci.
FI883388A 1987-07-17 1988-07-15 Förfarande för framställning av nya terapeutiskt användbara peptider FI91075C (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI933629A FI101884B (sv) 1987-07-17 1993-08-17 Antagonistpeptider till hormon som frigör luteiniserande hormon (LHRH)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7412687 1987-07-17
US07/074,126 US4800191A (en) 1987-07-17 1987-07-17 LHRH antagonists

Publications (4)

Publication Number Publication Date
FI883388A0 FI883388A0 (sv) 1988-07-15
FI883388A FI883388A (sv) 1989-01-18
FI91075B true FI91075B (sv) 1994-01-31
FI91075C FI91075C (sv) 1994-05-10

Family

ID=22117877

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883388A FI91075C (sv) 1987-07-17 1988-07-15 Förfarande för framställning av nya terapeutiskt användbara peptider

Country Status (18)

Country Link
US (2) US4800191A (sv)
EP (1) EP0299402B1 (sv)
JP (1) JP2944669B2 (sv)
AT (1) ATE90362T1 (sv)
BR (1) BR1100478A (sv)
CA (1) CA1339623C (sv)
DE (3) DE3881592D1 (sv)
DK (1) DK173375B1 (sv)
ES (1) ES2054741T3 (sv)
FI (1) FI91075C (sv)
HK (1) HK21194A (sv)
HU (1) HU206376B (sv)
IE (1) IE62744B1 (sv)
LU (1) LU90425I2 (sv)
LV (1) LV5795B4 (sv)
NL (1) NL990029I2 (sv)
PT (1) PT87998B (sv)
ZA (1) ZA885147B (sv)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
HU208158B (en) * 1990-02-20 1993-08-30 Syntex Inc Process for the synthesis of 1h-rh analogs by temporary protection
US5516887A (en) * 1991-04-25 1996-05-14 Romano Deghenghi Luteinizing hormone releasing hormone antagonist peptides
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
WO1993003752A1 (en) * 1991-08-19 1993-03-04 The Arizona Board Of Regents On Behalf Of The University Of Arizona Decapeptide having dopamine stimulating activity
US6468959B1 (en) * 1991-12-05 2002-10-22 Alfatec-Pharm Gmbh Peroral dosage form for peptide containing medicaments, in particular insulin
BE1005720A3 (fr) * 1992-03-20 1993-12-28 Solvay Procede de synthese peptidique et nouveaux intermediaires de synthese.
US6828415B2 (en) 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE4305225A1 (de) * 1993-02-19 1994-08-25 Asta Medica Ag Neues Herstellverfahren für Cetrorelix Lyophilisat
BE1007183A3 (fr) * 1993-06-18 1995-04-18 Solvay Ureines derivees d'alpha, omega-diaminoacides et procede pour leur preparation.
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
WO1995004541A1 (en) * 1993-08-06 1995-02-16 Abbott Laboratories N-terminus modified analogs of lhrh
US5502035A (en) * 1993-08-06 1996-03-26 Tap Holdings Inc. N-terminus modified analogs of LHRH
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5643605A (en) * 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US6080429A (en) * 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
CA2178592C (en) * 1993-12-09 2009-07-28 Jurgen Engel Long-acting injection suspensions and a process for their preparation
DE4342091A1 (de) * 1993-12-09 1995-06-14 Asta Medica Ag Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
US5916582A (en) * 1996-07-03 1999-06-29 Alza Corporation Aqueous formulations of peptides
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
DE19644994A1 (de) * 1996-10-30 1998-05-07 Asta Medica Ag Diagnostisches Mittel
US5925730A (en) 1997-04-11 1999-07-20 Ferring Bv GnRH antagonists
US5821230A (en) * 1997-04-11 1998-10-13 Ferring Bv GnRH antagonist decapeptides
US6407205B1 (en) * 1997-06-04 2002-06-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FSH-releasing peptides
DE19728737C1 (de) * 1997-07-04 1999-02-11 Johannes Christian Groeninghen Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten
US5941844A (en) * 1997-11-17 1999-08-24 Alza Corporation Method and device for controlling mammalian reproductive cycle
US6191115B1 (en) * 1998-08-12 2001-02-20 Abbott Laboratories C-terminus modified heptapeptide LHRH analogs
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
DE19911771B4 (de) * 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
DE10024451A1 (de) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
DE10040700A1 (de) * 2000-08-17 2002-02-28 Asta Medica Ag Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
WO2002047489A1 (en) 2000-12-15 2002-06-20 Wm. Wrigley Jr. Company Encapsulated acid mixtures and products including same
DE10157628A1 (de) * 2001-11-26 2003-06-12 Zentaris Ag Injektionslösung eines LHRH-Antagonisten
US7214662B2 (en) 2001-11-27 2007-05-08 Zentaris Gmbh Injectable solution of an LHRH antagonist
CN101647772A (zh) * 2008-08-12 2010-02-17 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂类物质的注射用缓释制剂及其制备
EP2379099A1 (en) 2009-01-22 2011-10-26 Maatschap Interne Geneeskunde Rijnstate Method for the prophylaxis or treatment of flushing
CN101863960B (zh) * 2009-04-15 2013-03-06 无锡市凯利药业有限公司 西曲瑞克的制备方法
EP2266567A1 (en) 2009-05-26 2010-12-29 Æterna Zentaris GmbH Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders
JP2014502282A (ja) 2010-12-06 2014-01-30 アストロン リサーチ リミテッド 安定な使用準備済みセトロレリックス注射液
US20220233631A1 (en) 2019-06-17 2022-07-28 Intas Pharmaceuticals Ltd. Stable formulation of cetrorelix
CN111875673B (zh) * 2020-07-31 2022-03-11 江苏莱森生物科技研究院有限公司 一种具有抗肿瘤活性的多肽及其用途
CN112175043A (zh) * 2020-10-12 2021-01-05 湖南津安生物科技有限公司 一种改进的鲑鱼促性腺激素释放激素的固相合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250759A (en) * 1961-08-18 1966-05-10 Olin Mathieson Citrulline containing peptides
AU9102582A (en) * 1981-12-10 1983-06-16 David Howard Coy Lh-rh antagonists
FI832053L (fi) * 1982-06-10 1983-12-11 Syntex Inc Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
EP0145032B1 (en) * 1983-08-16 1987-11-04 Akzo N.V. Lh- rh antagonists
US4565804A (en) * 1984-09-07 1986-01-21 The Salk Institute For Biological Studies GnRH Antagonists VI
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
EP0199302A2 (en) * 1985-04-19 1986-10-29 Syntex (U.S.A.) Inc. Contraception in dogs with luteinizing hormone releasing hormone antagonists
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists

Also Published As

Publication number Publication date
US5198533A (en) 1993-03-30
BR1100478A (pt) 2000-03-14
FI883388A (sv) 1989-01-18
IE882185L (en) 1989-01-17
HUT47311A (en) 1989-02-28
US4800191A (en) 1989-01-24
LV5795A4 (lv) 1997-02-20
JPS6434997A (en) 1989-02-06
DK395688A (da) 1989-01-18
DK173375B1 (da) 2000-09-11
FI91075C (sv) 1994-05-10
DE19975052I2 (de) 2009-01-02
HK21194A (en) 1994-03-18
JP2944669B2 (ja) 1999-09-06
DE3881592D1 (de) 1993-07-15
LV5795B4 (lv) 1997-08-20
HU206376B (en) 1992-10-28
EP0299402B1 (de) 1993-06-09
EP0299402A2 (de) 1989-01-18
ZA885147B (en) 1989-04-26
PT87998A (pt) 1989-06-30
DK395688D0 (da) 1988-07-15
NL990029I2 (nl) 2000-03-01
DE3823590A1 (de) 1989-01-26
NL990029I1 (nl) 1999-12-01
CA1339623C (en) 1998-01-06
ES2054741T3 (es) 1994-08-16
LU90425I2 (fr) 1999-10-04
PT87998B (pt) 1995-03-01
FI883388A0 (sv) 1988-07-15
ATE90362T1 (de) 1993-06-15
EP0299402A3 (en) 1990-06-06
IE62744B1 (en) 1995-02-22

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