PT87998A - Processo para a preparacao de peptidos antagonistas da hormona de libertacao da hormona luteinizante e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de peptidos antagonistas da hormona de libertacao da hormona luteinizante e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT87998A PT87998A PT87998A PT8799888A PT87998A PT 87998 A PT87998 A PT 87998A PT 87998 A PT87998 A PT 87998A PT 8799888 A PT8799888 A PT 8799888A PT 87998 A PT87998 A PT 87998A
- Authority
- PT
- Portugal
- Prior art keywords
- phe
- nal
- hormone
- pro
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/11—Gonadotropin; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/074,126 US4800191A (en) | 1987-07-17 | 1987-07-17 | LHRH antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
PT87998A true PT87998A (pt) | 1989-06-30 |
PT87998B PT87998B (pt) | 1995-03-01 |
Family
ID=22117877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87998A PT87998B (pt) | 1987-07-17 | 1988-07-15 | Processo para a preparacao de peptidos antagonistas da hormona de libertacao da hormona luteinizante e de composicoes farmaceuticas que os contem |
Country Status (18)
Country | Link |
---|---|
US (2) | US4800191A (pt) |
EP (1) | EP0299402B1 (pt) |
JP (1) | JP2944669B2 (pt) |
AT (1) | ATE90362T1 (pt) |
BR (1) | BR1100478A (pt) |
CA (1) | CA1339623C (pt) |
DE (3) | DE19975052I2 (pt) |
DK (1) | DK173375B1 (pt) |
ES (1) | ES2054741T3 (pt) |
FI (1) | FI91075C (pt) |
HK (1) | HK21194A (pt) |
HU (1) | HU206376B (pt) |
IE (1) | IE62744B1 (pt) |
LU (1) | LU90425I2 (pt) |
LV (1) | LV5795B4 (pt) |
NL (1) | NL990029I2 (pt) |
PT (1) | PT87998B (pt) |
ZA (1) | ZA885147B (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
US5171835A (en) * | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
US5169932A (en) * | 1989-10-30 | 1992-12-08 | The Salk Institute For Biological Studies | Gnrh analogs |
US5064939A (en) * | 1990-02-06 | 1991-11-12 | The Salk Institute For Biological Studies | Cyclic gnrh antagonists |
NO309428B1 (no) * | 1990-02-20 | 2001-01-29 | Syntex Inc | Fremgangsmåte for fast fase-syntese av en nona- og dekapeptid LH-RH analog |
DE593491T1 (de) * | 1991-04-25 | 1994-11-17 | Romano S.-Cergue Deghenghi | LHRH-Antagonisten. |
DE4117507A1 (de) * | 1991-05-24 | 1992-11-26 | Schering Ag | Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten |
CH683149A5 (fr) * | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
WO1993003752A1 (en) * | 1991-08-19 | 1993-03-04 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Decapeptide having dopamine stimulating activity |
US6468959B1 (en) * | 1991-12-05 | 2002-10-22 | Alfatec-Pharm Gmbh | Peroral dosage form for peptide containing medicaments, in particular insulin |
BE1005720A3 (fr) * | 1992-03-20 | 1993-12-28 | Solvay | Procede de synthese peptidique et nouveaux intermediaires de synthese. |
DE4305225A1 (de) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | Neues Herstellverfahren für Cetrorelix Lyophilisat |
US6828415B2 (en) | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
DE4320201A1 (de) * | 1993-06-18 | 1995-01-12 | Asta Medica Ag | Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation |
BE1007183A3 (fr) | 1993-06-18 | 1995-04-18 | Solvay | Ureines derivees d'alpha, omega-diaminoacides et procede pour leur preparation. |
US5413990A (en) * | 1993-08-06 | 1995-05-09 | Tap Pharmaceuticals Inc. | N-terminus modified analogs of LHRH |
CA2167834A1 (en) * | 1993-08-06 | 1995-02-16 | Fortuna Haviv | N-terminus modified analogs of lhrh |
US5502035A (en) * | 1993-08-06 | 1996-03-26 | Tap Holdings Inc. | N-terminus modified analogs of LHRH |
US6080429A (en) * | 1993-10-25 | 2000-06-27 | Genentech, Inc. | Method for drying microspheres |
US5643605A (en) * | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
US6913767B1 (en) | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
CA2178592C (en) * | 1993-12-09 | 2009-07-28 | Jurgen Engel | Long-acting injection suspensions and a process for their preparation |
DE4342091A1 (de) * | 1993-12-09 | 1995-06-14 | Asta Medica Ag | Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten |
US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
US5916582A (en) * | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
US5932547A (en) | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
US5981489A (en) * | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
DE19644994A1 (de) * | 1996-10-30 | 1998-05-07 | Asta Medica Ag | Diagnostisches Mittel |
US5821230A (en) * | 1997-04-11 | 1998-10-13 | Ferring Bv | GnRH antagonist decapeptides |
US5925730A (en) * | 1997-04-11 | 1999-07-20 | Ferring Bv | GnRH antagonists |
US6407205B1 (en) * | 1997-06-04 | 2002-06-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | FSH-releasing peptides |
DE19728737C1 (de) * | 1997-07-04 | 1999-02-11 | Johannes Christian Groeninghen | Verfahren zur Erkennung und Bestimmung von GnRH-Rezeptoren und die Verwendung von GnRH-Agonisten und GnRH-Antagonisten zur Behandlung eines Tumors ausgehend vom Hirn und/oder Nervensystem und/oder den Hirnhäuten |
US5941844A (en) * | 1997-11-17 | 1999-08-24 | Alza Corporation | Method and device for controlling mammalian reproductive cycle |
US6191115B1 (en) * | 1998-08-12 | 2001-02-20 | Abbott Laboratories | C-terminus modified heptapeptide LHRH analogs |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
DE19911771B4 (de) * | 1999-03-17 | 2006-03-30 | Zentaris Gmbh | LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung |
DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
DE10040700A1 (de) * | 2000-08-17 | 2002-02-28 | Asta Medica Ag | Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung |
AU1996802A (en) | 2000-12-15 | 2002-06-24 | Wrigley W M Jun Co | Encapsulated acid mixtures and products including same |
DE10157628A1 (de) * | 2001-11-26 | 2003-06-12 | Zentaris Ag | Injektionslösung eines LHRH-Antagonisten |
US7214662B2 (en) | 2001-11-27 | 2007-05-08 | Zentaris Gmbh | Injectable solution of an LHRH antagonist |
CN101647772A (zh) * | 2008-08-12 | 2010-02-17 | 中国人民解放军军事医学科学院毒物药物研究所 | Lhrh拮抗剂类物质的注射用缓释制剂及其制备 |
WO2010085145A1 (en) | 2009-01-22 | 2010-07-29 | Maatschap Interne Geneeskunde Rijnstate | Method for the prophylaxis or treatment of flushing |
CN101863960B (zh) * | 2009-04-15 | 2013-03-06 | 无锡市凯利药业有限公司 | 西曲瑞克的制备方法 |
EP2266567A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
US20130303464A1 (en) | 2010-12-06 | 2013-11-14 | Astron Research Limited | Stable ready-to-use cetrorelix injection |
JP2022537957A (ja) | 2019-06-17 | 2022-08-31 | インタス ファーマシューティカルズ リミテッド | セトロレリクスの安定な製剤 |
CN111875673B (zh) * | 2020-07-31 | 2022-03-11 | 江苏莱森生物科技研究院有限公司 | 一种具有抗肿瘤活性的多肽及其用途 |
CN112175043A (zh) * | 2020-10-12 | 2021-01-05 | 湖南津安生物科技有限公司 | 一种改进的鲑鱼促性腺激素释放激素的固相合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3250759A (en) * | 1961-08-18 | 1966-05-10 | Olin Mathieson | Citrulline containing peptides |
AU9102582A (en) * | 1981-12-10 | 1983-06-16 | David Howard Coy | Lh-rh antagonists |
FI832053L (fi) * | 1982-06-10 | 1983-12-11 | Syntex Inc | Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande |
EP0145032B1 (en) * | 1983-08-16 | 1987-11-04 | Akzo N.V. | Lh- rh antagonists |
US4565804A (en) * | 1984-09-07 | 1986-01-21 | The Salk Institute For Biological Studies | GnRH Antagonists VI |
US4690916A (en) * | 1984-11-13 | 1987-09-01 | Syntex (U.S.A.) Inc. | Nona and decapeptide analogs of LHRH useful as LHRH antagonists |
US4677193A (en) * | 1985-02-22 | 1987-06-30 | The Salk Institute For Biological Studies | Peptides containing an aliphatic-aromatic ketone side chain |
AU5638886A (en) * | 1985-04-19 | 1986-10-23 | Syntex (U.S.A.) Inc. | Contraceptive methods for dogs using the decapeptide lhrh |
US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
-
1987
- 1987-07-17 US US07/074,126 patent/US4800191A/en not_active Expired - Lifetime
-
1988
- 1988-05-23 US US07/197,153 patent/US5198533A/en not_active Expired - Lifetime
- 1988-07-11 AT AT88111031T patent/ATE90362T1/de active
- 1988-07-11 EP EP88111031A patent/EP0299402B1/de not_active Expired - Lifetime
- 1988-07-11 ES ES88111031T patent/ES2054741T3/es not_active Expired - Lifetime
- 1988-07-11 DE DE19975052C patent/DE19975052I2/de active Active
- 1988-07-11 DE DE8888111031T patent/DE3881592D1/de not_active Expired - Lifetime
- 1988-07-12 DE DE3823590A patent/DE3823590A1/de not_active Withdrawn
- 1988-07-15 CA CA000572236A patent/CA1339623C/en not_active Expired - Lifetime
- 1988-07-15 DK DK198803956A patent/DK173375B1/da not_active IP Right Cessation
- 1988-07-15 ZA ZA885147A patent/ZA885147B/xx unknown
- 1988-07-15 FI FI883388A patent/FI91075C/fi active IP Right Grant
- 1988-07-15 IE IE218588A patent/IE62744B1/en not_active IP Right Cessation
- 1988-07-15 HU HU883701A patent/HU206376B/hu unknown
- 1988-07-15 PT PT87998A patent/PT87998B/pt not_active IP Right Cessation
- 1988-07-18 JP JP63177288A patent/JP2944669B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-10 HK HK211/94A patent/HK21194A/xx not_active IP Right Cessation
-
1996
- 1996-07-22 LV LV960300A patent/LV5795B4/xx unknown
-
1997
- 1997-05-06 BR BR1100478-9A patent/BR1100478A/pt active IP Right Grant
-
1999
- 1999-08-04 LU LU90425C patent/LU90425I2/fr unknown
- 1999-09-24 NL NL990029C patent/NL990029I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
ATE90362T1 (de) | 1993-06-15 |
FI883388A (fi) | 1989-01-18 |
IE882185L (en) | 1989-01-17 |
ES2054741T3 (es) | 1994-08-16 |
CA1339623C (en) | 1998-01-06 |
EP0299402A3 (en) | 1990-06-06 |
FI883388A0 (fi) | 1988-07-15 |
DK173375B1 (da) | 2000-09-11 |
FI91075B (fi) | 1994-01-31 |
HU206376B (en) | 1992-10-28 |
BR1100478A (pt) | 2000-03-14 |
JPS6434997A (en) | 1989-02-06 |
DK395688A (da) | 1989-01-18 |
DE3881592D1 (de) | 1993-07-15 |
DK395688D0 (da) | 1988-07-15 |
NL990029I2 (nl) | 2000-03-01 |
JP2944669B2 (ja) | 1999-09-06 |
EP0299402B1 (de) | 1993-06-09 |
LV5795A4 (lv) | 1997-02-20 |
ZA885147B (en) | 1989-04-26 |
HK21194A (en) | 1994-03-18 |
EP0299402A2 (de) | 1989-01-18 |
IE62744B1 (en) | 1995-02-22 |
LU90425I2 (fr) | 1999-10-04 |
HUT47311A (en) | 1989-02-28 |
DE19975052I2 (de) | 2009-01-02 |
DE3823590A1 (de) | 1989-01-26 |
LV5795B4 (lv) | 1997-08-20 |
US5198533A (en) | 1993-03-30 |
FI91075C (fi) | 1994-05-10 |
US4800191A (en) | 1989-01-24 |
PT87998B (pt) | 1995-03-01 |
NL990029I1 (nl) | 1999-12-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19940817 |
|
TE3A | Change of address (patent) |
Owner name: ASTA MEDICA AKTIENGESELLSCHAFT Effective date: 19990929 |
|
PC3A | Transfer or assignment |
Free format text: 20020311 ZENTARIS AG DE |
|
PD3A | Change of proprietorship |
Owner name: ASTA MEDICA GMBH Effective date: 20020311 |
|
PC3A | Transfer or assignment |
Free format text: ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND US Effective date: 20030606 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090817 |