FI905701A - Fluoresenssienergiansiirtoon perustuva biosensori ja menetelmä analyyttimolekyylien havaitsemiseksi sen avulla - Google Patents
Fluoresenssienergiansiirtoon perustuva biosensori ja menetelmä analyyttimolekyylien havaitsemiseksi sen avulla Download PDFInfo
- Publication number
- FI905701A FI905701A FI905701A FI905701A FI905701A FI 905701 A FI905701 A FI 905701A FI 905701 A FI905701 A FI 905701A FI 905701 A FI905701 A FI 905701A FI 905701 A FI905701 A FI 905701A
- Authority
- FI
- Finland
- Prior art keywords
- receptor
- energy transfer
- ligand
- film
- fluorescence energy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/552—Glass or silica
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19893938598 DE3938598A1 (de) | 1989-11-21 | 1989-11-21 | Optischer biosensor |
DE3938598 | 1989-11-21 | ||
DE4013713 | 1990-04-28 | ||
DE19904013713 DE4013713A1 (de) | 1990-04-28 | 1990-04-28 | Optischer biosensor |
Publications (4)
Publication Number | Publication Date |
---|---|
FI905701A0 FI905701A0 (fi) | 1990-11-19 |
FI905701A true FI905701A (fi) | 1991-05-22 |
FI98570B FI98570B (fi) | 1997-03-27 |
FI98570C FI98570C (fi) | 1997-07-10 |
Family
ID=25887278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI905701A FI98570C (fi) | 1989-11-21 | 1990-11-19 | Fluoresenssienergiansiirtoon perustuva biosensori ja menetelmä analyyttimolekyylien havaitsemiseksi sen avulla |
Country Status (8)
Country | Link |
---|---|
US (1) | US5194393A (fi) |
EP (1) | EP0429907B1 (fi) |
JP (1) | JPH03176662A (fi) |
AT (1) | ATE106566T1 (fi) |
CA (1) | CA2030244A1 (fi) |
DE (1) | DE59005928D1 (fi) |
DK (1) | DK0429907T3 (fi) |
FI (1) | FI98570C (fi) |
Families Citing this family (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4121426A1 (de) * | 1991-06-28 | 1993-01-14 | Basf Ag | Chemischer sensor |
US5587472A (en) * | 1991-08-13 | 1996-12-24 | Bayer Corporation | Coumarin-labeled nucleoside 5'-triphosphates |
US5246867A (en) * | 1992-01-17 | 1993-09-21 | University Of Maryland At Baltimore | Determination and quantification of saccharides by luminescence lifetimes and energy transfer |
EP0552107A1 (en) * | 1992-01-17 | 1993-07-21 | The University Of Maryland At Baltimore | pH and pCO2, sensing by luminescent lifetimes and energy transfer |
DE4208645A1 (de) * | 1992-03-18 | 1993-09-23 | Bayer Ag | Optischer festphasenbiosensor auf basis fluoreszenzfarbstoffmarkierter polyionischer schichten |
US5512328A (en) * | 1992-08-07 | 1996-04-30 | Hitachi, Ltd. | Method for forming a pattern and forming a thin film used in pattern formation |
DE4319037A1 (de) * | 1993-06-08 | 1994-12-15 | Bayer Ag | Beschichtete Träger, Verfahren zu ihrer Herstellung und ihre Verwendung zur Immobilisierung von Biomolekülen an Oberlfächen von Festkörpern |
US5552272A (en) * | 1993-06-10 | 1996-09-03 | Biostar, Inc. | Detection of an analyte by fluorescence using a thin film optical device |
US7083984B2 (en) | 1993-09-24 | 2006-08-01 | Biosite, Inc. | Hybrid phthalocyanine derivatives and their uses |
US5824799A (en) * | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
US6251687B1 (en) | 1993-09-24 | 2001-06-26 | Biosite Diagnostics, Inc. | Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds |
US6238931B1 (en) * | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
US7322927B2 (en) | 1993-09-24 | 2008-01-29 | Biosite, Inc. | Hybrid phthalocyanine derivatives and their uses |
US5496522A (en) * | 1994-02-07 | 1996-03-05 | Martin Marietta Energy Systems, Inc. | Biosensor and chemical sensor probes for calcium and other metal ions |
US5577137A (en) * | 1995-02-22 | 1996-11-19 | American Research Corporation Of Virginia | Optical chemical sensor and method using same employing a multiplicity of fluorophores contained in the free volume of a polymeric optical waveguide or in pores of a ceramic waveguide |
US5871915A (en) * | 1995-03-13 | 1999-02-16 | Research Development Corporation Of Japan | Method for detecting nucleic acid polymer |
US5591407A (en) * | 1995-04-21 | 1997-01-07 | American Research Corporation Of Virginia | Laser diode sensor |
US5690894A (en) | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5661035A (en) * | 1995-06-07 | 1997-08-26 | The Regents Of The University Of California | Voltage sensing by fluorescence resonance energy transfer |
US6596522B2 (en) | 1997-05-08 | 2003-07-22 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
US6342379B1 (en) | 1995-06-07 | 2002-01-29 | The Regents Of The University Of California | Detection of transmembrane potentials by optical methods |
US5792621A (en) * | 1995-06-28 | 1998-08-11 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Fiber-optic chemiluminescent biosensors for monitoring aqueous alcohols and other water quality parameters |
DE19530078A1 (de) * | 1995-08-16 | 1997-02-20 | Bayer Ag | Optischer Festphasenbiosensor auf Basis von Streptavidin und Biotin |
US5837196A (en) * | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5854863A (en) * | 1996-03-15 | 1998-12-29 | Erb; Judith | Surface treatment and light injection method and apparatus |
US5671303A (en) * | 1996-04-17 | 1997-09-23 | Motorola, Inc. | Molecular detection apparatus and method using optical waveguide detection |
US6251691B1 (en) * | 1996-04-25 | 2001-06-26 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
US6103535A (en) * | 1996-05-31 | 2000-08-15 | University Of Maryland | Optical fiber evanescent field excited fluorosensor and method of manufacture |
FI102922B (fi) * | 1996-06-28 | 1999-03-15 | Valtion Teknillinen | Fluoresenssiin perustuva immunomääritysmenetelmä |
DE19628002C1 (de) * | 1996-07-11 | 1997-12-18 | Inst Chemo Biosensorik | Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests |
US6348322B1 (en) * | 1997-10-17 | 2002-02-19 | Duke University | Method of screening for specific binding interactions |
US6475722B1 (en) * | 1997-12-03 | 2002-11-05 | Curagen Corporation | Surface treatments for DNA processing devices |
US6289229B1 (en) | 1998-01-20 | 2001-09-11 | Scimed Life Systems, Inc. | Readable probe array for in vivo use |
US6051437A (en) * | 1998-05-04 | 2000-04-18 | American Research Corporation Of Virginia | Optical chemical sensor based on multilayer self-assembled thin film sensors for aquaculture process control |
US20050147534A1 (en) * | 1998-05-05 | 2005-07-07 | Massachusetts Institute Of Technology | Emissive sensors and devices incorporating these sensors |
US8198096B2 (en) * | 1998-05-05 | 2012-06-12 | Massachusetts Institute Of Technology | Emissive polymers and devices incorporating these polymers |
ATE409215T1 (de) * | 1998-05-05 | 2008-10-15 | Massachusetts Inst Technology | Emittierende polymere und vorrichtungen diese polymere enthaltend |
US6297059B1 (en) | 1998-06-22 | 2001-10-02 | The Regents Of The University Of California | Triggered optical biosensor |
US6277651B1 (en) | 1998-07-09 | 2001-08-21 | Calspan Srl Corporation | Diode laser electrochemical sensor for detecting chemical and biological analytes |
US7166475B2 (en) * | 1999-02-26 | 2007-01-23 | Cyclacel Ltd. | Compositions and methods for monitoring the modification state of a pair of polypeptides |
US7167615B1 (en) | 1999-11-05 | 2007-01-23 | Board Of Regents, The University Of Texas System | Resonant waveguide-grating filters and sensors and methods for making and using same |
EP1122535A3 (en) * | 2000-01-31 | 2004-09-22 | The Penn State Research Foundation | Interrogation of changes in the contents of a sealed container |
US6743640B2 (en) * | 2000-05-08 | 2004-06-01 | Qtl Biosystems Llc | Fluorescent polymer-QTL approach to biosensing |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
DE60117556T2 (de) | 2000-06-21 | 2006-11-02 | Bioarray Solutions Ltd. | Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays |
WO2002016463A2 (en) * | 2000-08-21 | 2002-02-28 | Massachusetts Institute Of Technology | Polymers with high internal free volume |
US6706479B2 (en) | 2000-10-05 | 2004-03-16 | Virginia Tech Intellectual Properties, Inc. | Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips |
US20030045005A1 (en) * | 2000-10-17 | 2003-03-06 | Michael Seul | Light-controlled electrokinetic assembly of particles near surfaces |
AT410601B (de) * | 2000-12-29 | 2003-06-25 | Hoffmann La Roche | Sensor zur lumineszenz-optischen bestimmung eines analyten sowie reagens, das nach dem fret-prinzip arbeitet |
US20040243093A1 (en) * | 2001-01-10 | 2004-12-02 | Ron Berenson | System for growth, analysis, storage, validation and distribution of cells and tissues used for biomedical purposes |
US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
US7297311B2 (en) * | 2001-06-29 | 2007-11-20 | Sysmex Corporation | Automatic smear preparing apparatus and automatic sample analysis system having the same |
US7723113B2 (en) * | 2001-08-20 | 2010-05-25 | Bayer Healthcare Llc | Packaging system for test sensors |
NZ532947A (en) | 2001-10-15 | 2006-01-27 | Bioarray Solutions Ltd | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
US7462325B2 (en) * | 2001-11-30 | 2008-12-09 | Nomadics, Inc. | Luminescent polymer particles |
CA2419905C (en) | 2002-03-18 | 2016-01-05 | Bayer Healthcare, Llc | Storage cartridge for biosensors |
AU2003269913A1 (en) * | 2002-07-15 | 2004-02-02 | Massachusetts Institute Of Technology | Emissive, high charge transport polymers |
AU2003298655A1 (en) | 2002-11-15 | 2004-06-15 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
US20040121337A1 (en) * | 2002-12-19 | 2004-06-24 | Nomadics, Inc. | Luminescent polymers and methods of use thereof |
WO2004081570A1 (fr) * | 2003-03-13 | 2004-09-23 | Chengdu Kuachang Medical Industrial Limited | Matrice de puce, puce comprenant une matrice et leur preparation et application |
US7364699B2 (en) * | 2003-06-18 | 2008-04-29 | Bayer Healthcare Llc | Containers for reading and handling diagnostic reagents and methods of using the same |
US20040267299A1 (en) * | 2003-06-30 | 2004-12-30 | Kuriger Rex J. | Lancing devices and methods of using the same |
WO2005029705A2 (en) | 2003-09-18 | 2005-03-31 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
ATE532066T1 (de) | 2003-09-22 | 2011-11-15 | Bioarray Solutions Ltd | Oberflächenimmobilisierter polyelektrolyt mit mehreren, zur kovalenten bindung an biomoleküle fähigen funktionellen gruppen |
WO2005042763A2 (en) | 2003-10-28 | 2005-05-12 | Bioarray Solutions Ltd. | Optimization of gene expression analysis using immobilized capture probes |
EP1694859B1 (en) | 2003-10-29 | 2015-01-07 | Bioarray Solutions Ltd | Multiplexed nucleic acid analysis by fragmentation of double-stranded dna |
GB0329161D0 (en) * | 2003-12-16 | 2004-01-21 | Precisense As | Reagant for detecting an analyte |
EP1544602B1 (en) * | 2003-12-19 | 2008-05-07 | STMicroelectronics Limited | Bio-optical sensors |
WO2005064337A1 (en) * | 2003-12-22 | 2005-07-14 | Koninklijke Philips Electronics N.V. | Optical nanowire biosensor based on energy transfer |
GB0329849D0 (en) * | 2003-12-23 | 2004-01-28 | Precisense As | Fluorometers |
EP1714147B1 (en) * | 2004-02-06 | 2014-07-23 | Bayer HealthCare LLC | Fluid testing sensor having vents for directing fluid flow |
WO2006096185A2 (en) * | 2004-03-25 | 2006-09-14 | The Government Of The United States Of American, As Represented By The Secretary Of The Navy | Reagentless and reusable biosensors with tunable differential binding affinites and methods of making |
GB0411162D0 (en) * | 2004-05-19 | 2004-06-23 | Precisense As | Optical sensor for in vivo detection of analyte |
GB0416732D0 (en) * | 2004-07-27 | 2004-09-01 | Precisense As | A method and apparatus for measuring the phase shift induced in a light signal by a sample |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
WO2006034081A2 (en) * | 2004-09-17 | 2006-03-30 | Massachusetts Institute Of Technology | Polymers for analyte detection |
RU2007118686A (ru) * | 2004-10-20 | 2008-11-27 | БАЙЕР ХЕЛТКЭА ЭлЭлСи (US) | Картридж для хранения и выдачи тестовых датчиков |
US8329390B2 (en) | 2004-10-21 | 2012-12-11 | Anaspec Incorporated | Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols |
DE102004051830B4 (de) * | 2004-10-25 | 2007-12-13 | Roche Diagnostics Gmbh | Multifunktionales Referenzsystem bei Analytbestimmungen durch Fluoreszenz |
GB0426822D0 (en) * | 2004-12-07 | 2005-01-12 | Precisense As | Sensor for detection of glucose |
GB0426823D0 (en) * | 2004-12-07 | 2005-01-12 | Precisense As | Sensor for detection of glucose |
DE602005027907D1 (de) | 2004-12-13 | 2011-06-16 | Bayer Healthcare Llc | Transmissionspektroskopiesystem zur verwendung bei der bestimmung von analyten in körperflüssigkeit |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
CA2624059C (en) | 2005-09-30 | 2019-04-02 | Intuity Medical, Inc. | Multi-site body fluid sampling and analysis cartridge |
US8158437B2 (en) * | 2006-08-04 | 2012-04-17 | Massachusetts Institute Of Technology | Luminescent detection of hydrazine and hydrazine derivatives |
WO2008042289A2 (en) | 2006-09-29 | 2008-04-10 | Massachusetts Institute Of Technology | Polymer synthetic technique |
US8802447B2 (en) * | 2006-10-05 | 2014-08-12 | Massachusetts Institute Of Technology | Emissive compositions with internal standard and related techniques |
US7797987B2 (en) * | 2006-10-11 | 2010-09-21 | Bayer Healthcare Llc | Test sensor with a side vent and method of making the same |
US20090215189A1 (en) | 2006-10-27 | 2009-08-27 | Massachusetts Institute Of Technology | Sensor of species including toxins and chemical warfare agents |
WO2008057479A2 (en) * | 2006-11-07 | 2008-05-15 | Bayer Healthcare Llc | Method of making an auto-calibrating test sensor |
US20090288964A1 (en) * | 2006-12-13 | 2009-11-26 | Sung-Kwon Jung | Biosensor with coded information and method for manufacturing the same |
US20080248581A1 (en) | 2007-04-06 | 2008-10-09 | Bayer Healthcare Llc | Method for performing correction of blood glucose assay bias using blood hemoglobin concentration |
MX2010001470A (es) * | 2007-08-06 | 2010-03-01 | Bayer Healthcare Llc | Sistema y metodo para la calibracion automatica. |
US8241488B2 (en) | 2007-11-06 | 2012-08-14 | Bayer Healthcare Llc | Auto-calibrating test sensors |
US20090205399A1 (en) * | 2008-02-15 | 2009-08-20 | Bayer Healthcare, Llc | Auto-calibrating test sensors |
EP2293719B1 (en) | 2008-05-30 | 2015-09-09 | Intuity Medical, Inc. | Body fluid sampling device -- sampling site interface |
WO2009148624A1 (en) | 2008-06-06 | 2009-12-10 | Intuity Medical, Inc. | Detection meter and mode of operation |
US8424763B2 (en) * | 2008-10-07 | 2013-04-23 | Bayer Healthcare Llc | Method of forming an auto-calibration circuit or label |
EP2344863A2 (en) | 2008-10-21 | 2011-07-20 | Bayer HealthCare LLC | Optical auto-calibration method |
DK2380009T3 (en) | 2008-12-18 | 2015-05-04 | Bayer Healthcare Llc | Device for determining the temperature of a test sensor |
WO2011065981A1 (en) | 2009-11-30 | 2011-06-03 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
EP3750480B1 (en) | 2011-08-03 | 2022-02-02 | Intuity Medical, Inc. | Body fluid sampling arrangement |
US9417229B2 (en) | 2011-12-20 | 2016-08-16 | Ascensia Diabetes Care Holdings Ag | Linear, cartridge-based glucose measurement system |
CN104244944B (zh) | 2011-12-30 | 2018-06-08 | Ptc医疗公司 | 用于治疗脊髓性肌萎缩症的化合物 |
EP3588086B1 (en) | 2012-05-31 | 2022-08-03 | Ascensia Diabetes Care Holdings AG | Replaceable multistrip cartridge and biosensor meter |
CN104520709B (zh) | 2012-05-31 | 2016-12-07 | 安晟信医疗科技控股公司 | 多条盒 |
JP6396411B2 (ja) | 2013-03-12 | 2018-09-26 | アセンシア・ディアベティス・ケア・ホールディングス・アーゲー | テストストリップを光学式読み取り装置に押し付ける機構を有するテストストリップ測定器 |
US9376708B2 (en) | 2013-03-13 | 2016-06-28 | Ascensia Diabetes Care Holdings Ag | Bottled glucose sensor with no handling |
CA2951540A1 (en) | 2014-06-19 | 2015-12-23 | Ascensia Diabetes Care Holdings Ag | Sensor clip for stacked sensor dispensing system, and systems, methods and devices for making and using the same |
US20200166456A1 (en) * | 2018-09-27 | 2020-05-28 | Cornell University | Super-resolution optical imaging of non-fluorescent species |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4261968A (en) * | 1979-05-10 | 1981-04-14 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
EP0150905A3 (en) * | 1984-01-05 | 1987-01-14 | Ortho Diagnostic Systems Inc. | Anti-idiotype assay using fluorescent energy transfer |
US4666862A (en) * | 1984-08-14 | 1987-05-19 | Ortho Diagnostic Systems Inc. | Fluorescent energy transfer with phycobiliproteins |
US4777128A (en) * | 1986-05-27 | 1988-10-11 | Ethigen Corporation | Fluorescence immunoassay involving energy transfer between two fluorophores |
JPS62294085A (ja) * | 1986-06-13 | 1987-12-21 | Seiko Instr & Electronics Ltd | 有機薄膜、その製造方法および有機薄膜を利用した素子 |
CA1317206C (en) * | 1986-09-22 | 1993-05-04 | Takeyuki Kawaguchi | Method for detecting a component of a biological system and detection device and kit therefor |
US5037615A (en) * | 1987-10-30 | 1991-08-06 | Cordis Corporation | Tethered pair fluorescence energy transfer indicators, chemical sensors, and method of making such sensors |
-
1990
- 1990-11-08 AT AT90121347T patent/ATE106566T1/de not_active IP Right Cessation
- 1990-11-08 EP EP90121347A patent/EP0429907B1/de not_active Expired - Lifetime
- 1990-11-08 DE DE59005928T patent/DE59005928D1/de not_active Expired - Lifetime
- 1990-11-08 DK DK90121347.0T patent/DK0429907T3/da active
- 1990-11-08 US US07/611,197 patent/US5194393A/en not_active Expired - Lifetime
- 1990-11-15 JP JP2307346A patent/JPH03176662A/ja active Pending
- 1990-11-19 FI FI905701A patent/FI98570C/fi not_active IP Right Cessation
- 1990-11-19 CA CA002030244A patent/CA2030244A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0429907A3 (en) | 1991-10-16 |
EP0429907B1 (de) | 1994-06-01 |
CA2030244A1 (en) | 1991-05-22 |
US5194393A (en) | 1993-03-16 |
FI98570C (fi) | 1997-07-10 |
EP0429907A2 (de) | 1991-06-05 |
FI905701A0 (fi) | 1990-11-19 |
DE59005928D1 (de) | 1994-07-07 |
JPH03176662A (ja) | 1991-07-31 |
DK0429907T3 (da) | 1994-10-03 |
FI98570B (fi) | 1997-03-27 |
ATE106566T1 (de) | 1994-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI98570B (fi) | Fluoresenssienergiansiirtoon perustuva biosensori ja menetelmä analyyttimolekyylien havaitsemiseksi sen avulla | |
US6335205B1 (en) | Method and test strip for determining an analyte | |
CA2198958C (en) | Method for amplification of the response signal in a sandwich immunoassay | |
US20030032199A1 (en) | Device and method for carrying out fluorescence immunotests | |
Wadkins et al. | Detection of multiple toxic agents using a planar array immunosensor | |
US5827748A (en) | Chemical sensor using two-dimensional lens array | |
DE59308625D1 (de) | Optischer Festphasenbiosensor auf Basis fluoreszenzfarbstoffmarkierter polyionischer Schichten | |
NL7509587A (nl) | Werkwijze voor het in een azolyseoplossing bepalen van de aanwezigheid van een ligand in een onbekende waarvan vermoed wordt dat deze de ligand bevat. | |
JP2003503732A (ja) | センサープラットホーム、そのプラットホームを組み込んだ器具、およびそのプラットホームを使用する方法 | |
KR970074793A (ko) | 올리고머화된 수용체를 사용한 결정 방법 | |
ATE302412T1 (de) | Fluoreszierende markierungskomplexe mit grossem stokes-shift die durch verbindung von cyaninen und anderen resonanzenergieübertragungsfähigen fluorochromen zusammengestellt sind | |
JPH01113662A (ja) | 特異的結合アッセイ装置および方法 | |
DE69716454D1 (de) | Nachweisverfahren mit hilfe von fluoreszent-energietransferliganden auf lipidfilmen | |
ATE113962T1 (de) | Von polypeptiden induzierte monoklonale antikörper gegen oncoproteine. | |
CA2019980C (en) | Analytical assay method | |
Takmakov et al. | Application of anodized aluminum in fluorescence detection of biological species | |
RU2194972C2 (ru) | Устройство и способ для проведения иммунофлуоресцентных анализов | |
Wadkins et al. | Patterned planar array immunosensor for multianalyte detection | |
KR101432073B1 (ko) | 다중-표적분자 동시검출용 고감도 복합-나노바이오칩 및 이를 이용한 질병진단의 정보제공방법 | |
Miller | Luminescence measurements on surfaces | |
GR920100123A (el) | Αντιδραστήριο πολυχρωματικής κηλίδωσης και μέ?οδος ανάλυσης. | |
Kawai et al. | Inkjet Printing-Based Immobilization Method for a Single-Step and Homogeneous Competitive Immunoassay in Microchannel Arrays | |
EP2252878A1 (en) | Biosensor and a related manufacturing method | |
JPH01321361A (ja) | 乾式免疫分析要素 | |
JPH01237455A (ja) | 乾式免疫分析要素 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Owner name: BAYER AKTIENGESELLSCHAFT |
|
BB | Publication of examined application | ||
MM | Patent lapsed | ||
MM | Patent lapsed |
Owner name: BAYER AKTIENGESELLSCHAFT |