FI90415B - Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner - Google Patents

Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner Download PDF

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Publication number
FI90415B
FI90415B FI882001A FI882001A FI90415B FI 90415 B FI90415 B FI 90415B FI 882001 A FI882001 A FI 882001A FI 882001 A FI882001 A FI 882001A FI 90415 B FI90415 B FI 90415B
Authority
FI
Finland
Prior art keywords
formula
ethoxycarbonyl
methoxycarbonyl
chlorophenyl
methyl
Prior art date
Application number
FI882001A
Other languages
English (en)
Finnish (fi)
Other versions
FI882001A (sv
FI90415C (sv
FI882001A0 (sv
Inventor
Simon Fraser Campbell
Alan Stobie
Michael John Humphrey
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of FI882001A0 publication Critical patent/FI882001A0/sv
Publication of FI882001A publication Critical patent/FI882001A/sv
Publication of FI90415B publication Critical patent/FI90415B/sv
Application granted granted Critical
Publication of FI90415C publication Critical patent/FI90415C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (5)

1. Framställningsförfarande för ett terapeutiskt ' användbart dihydropyridinderivat, eller ett farmaceutiskt 5 godtagbart sait därav, med formeln I H ίο / COOC.H,. ( 1 ) j li Tr 2 5 A JO f2 CH3 n CH2CXa2CH2NHCOCH2CH2CHCOR1 a 15 väri R1 är -OR2 eller -NH2, väri R2 är H, C1.6-alkyl, fenyl eller bensyl, kännetecknat därav, att amino-skyddsgruppen R avlägsnas frän en förening med formeln 20 V/C1 (A) CH COOCH J Tl Γτ 2 5 25. f® CH3 f C^20C^2C^',N^^'0<'ii2C‘^^<'iiC'0R ^ H väri R är en aminoskyddsgrupp och R1 betecknar samma som i 30 formeln I; efter nämnda förfarande omvandlas produkten med formeln I om sä önskas tili ett farmaceutiskt godtagbart sait.
2. Framställningsförfarande enligt patentkrav 1, 35 kännetecknat därav, att R1 är -OH. 26 9 0 4 1 5
3. Framställningsförfarande enligt patentkrav 1 eller 2, kännetecknat därav, att R är bensyl-oxikarbonyl eller t-butoxikarbonyl.
4. Framställningsförfarande enligt patentkrav 3, 5 kännetecknat därav, att bensyloxikarbonylgrup- pen avlägsnas genom katalytisk hydrering och t-butoxikar-bonylgruppen genom syrabehandling.
5. Framställningsförfarande enligt patentkrav 4, kännetecknat därav, att syran är väteklorid- 10 gas.
FI882001A 1987-05-02 1988-04-28 Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner FI90415C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8710493 1987-05-02
GB878710493A GB8710493D0 (en) 1987-05-02 1987-05-02 Dihydropyridines

Publications (4)

Publication Number Publication Date
FI882001A0 FI882001A0 (sv) 1988-04-28
FI882001A FI882001A (sv) 1988-11-03
FI90415B true FI90415B (sv) 1993-10-29
FI90415C FI90415C (sv) 1994-02-10

Family

ID=10616773

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882001A FI90415C (sv) 1987-05-02 1988-04-28 Förfarande för framställning av terapeutiskt användbara substituerade 2-(2-aminoetoximetyl)-4-(2-klorfenyl)-3-etoxikarbonyl-5-metoxikarbonyl-6-metyl-1,4-dihydropyridiner

Country Status (13)

Country Link
US (1) US4806557A (sv)
EP (1) EP0290211B1 (sv)
JP (1) JPS63297365A (sv)
AT (1) ATE66915T1 (sv)
CA (1) CA1326672C (sv)
DE (1) DE3864573D1 (sv)
DK (1) DK172094B1 (sv)
ES (1) ES2031595T3 (sv)
FI (1) FI90415C (sv)
GB (1) GB8710493D0 (sv)
GR (1) GR3002767T3 (sv)
IE (1) IE60055B1 (sv)
PT (1) PT87361B (sv)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
JP4773010B2 (ja) * 1999-06-25 2011-09-14 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｍｐｄｈのカーバメート阻害剤のプロドラッグ
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
GB0008332D0 (en) * 2000-04-04 2000-05-24 Pfizer Ltd Treament
CA2433191A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Aspartate derivative of amlodipine as calcium channel antagonist
EP1309556B1 (en) 2000-12-29 2004-11-24 Pfizer Limited Amlodipine fumarate
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
BR0116554A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para o tratamento da angina ou hipertensão, processo, processo para o tratamento ou prevenção da angina ou hipertensão, composição do ingrediente farmaceuticamente ativo e composição farmacêutica para o tratamento ou prevenção da angina ou hipertensão
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
CA2433284A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
MXPA03005885A (es) 2000-12-29 2005-04-19 Pfizer Ltd Procedimiento para fabricar maleato de amlodipina.
ATE315026T1 (de) 2000-12-29 2006-02-15 Pfizer Ltd Amlodipin-hemimaleat
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
KR20040011751A (ko) * 2002-07-30 2004-02-11 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100496436B1 (ko) * 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR100462304B1 (ko) * 2002-07-30 2004-12-17 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
BR112012028153A2 (pt) 2010-05-03 2018-08-07 Tsh Biopharm Corporation Ltd composição farmacêutica e método para o tratamento de hipertensão

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
US4447613A (en) * 1979-08-24 1984-05-08 Zoecon Corporation Pyridyl esters and thiolesters of aminoalkanoic acids
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
PT87361B (pt) 1992-08-31
CA1326672C (en) 1994-02-01
DE3864573D1 (en) 1991-10-10
IE881283L (en) 1988-11-02
ATE66915T1 (de) 1991-09-15
JPS63297365A (ja) 1988-12-05
DK172094B1 (da) 1997-10-20
ES2031595T3 (es) 1992-12-16
IE60055B1 (en) 1994-05-18
GR3002767T3 (en) 1993-01-25
GB8710493D0 (en) 1987-06-03
EP0290211B1 (en) 1991-09-04
PT87361A (pt) 1989-05-31
JPH0581588B2 (sv) 1993-11-15
DK234388A (da) 1989-01-19
DK234388D0 (da) 1988-04-28
US4806557A (en) 1989-02-21
FI882001A (sv) 1988-11-03
FI90415C (sv) 1994-02-10
FI882001A0 (sv) 1988-04-28
EP0290211A1 (en) 1988-11-09

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Owner name: PFIZER LIMITED