FI901678A0 - Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita - Google Patents

Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita

Info

Publication number
FI901678A0
FI901678A0 FI901678A FI901678A FI901678A0 FI 901678 A0 FI901678 A0 FI 901678A0 FI 901678 A FI901678 A FI 901678A FI 901678 A FI901678 A FI 901678A FI 901678 A0 FI901678 A0 FI 901678A0
Authority
FI
Finland
Prior art keywords
deoxy
preparation
substituted methyl
intermediates used
methyl nucleosides
Prior art date
Application number
FI901678A
Other languages
English (en)
Swedish (sv)
Other versions
FI95384C (fi
FI95384B (fi
Inventor
Roman Z Sterzycki
Muzammil M Mansuri
John C Martin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of FI901678A0 publication Critical patent/FI901678A0/fi
Priority to FI942677A priority Critical patent/FI942677A0/fi
Priority to FI942676A priority patent/FI942676A/fi
Priority to FI942678A priority patent/FI942678A0/fi
Application granted granted Critical
Publication of FI95384B publication Critical patent/FI95384B/fi
Publication of FI95384C publication Critical patent/FI95384C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI901678A 1989-04-06 1990-04-03 Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita FI95384C (fi)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI942677A FI942677A0 (fi) 1989-04-06 1994-06-07 Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi
FI942676A FI942676A (fi) 1989-04-06 1994-06-07 Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi
FI942678A FI942678A0 (fi) 1989-04-06 1994-06-07 Menetelmä 3'-deoksi-3-'fluorimetyylinukleosidijohdannaisten valmistamiseksi

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33403489A 1989-04-06 1989-04-06
US33403489 1989-04-06
US49245090A 1990-03-13 1990-03-13
US49245090 1990-03-13

Publications (3)

Publication Number Publication Date
FI901678A0 true FI901678A0 (fi) 1990-04-03
FI95384B FI95384B (fi) 1995-10-13
FI95384C FI95384C (fi) 1996-01-25

Family

ID=26989019

Family Applications (1)

Application Number Title Priority Date Filing Date
FI901678A FI95384C (fi) 1989-04-06 1990-04-03 Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita

Country Status (6)

Country Link
EP (1) EP0391411A3 (fi)
KR (1) KR930005991B1 (fi)
AU (1) AU633065B2 (fi)
CA (1) CA2013874A1 (fi)
FI (1) FI95384C (fi)
PT (1) PT93691B (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5272152A (en) * 1990-07-02 1993-12-21 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl tetrahydrofurans
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
WO1995032983A1 (en) * 1994-05-31 1995-12-07 Medivir Ab Post exposure prevention of hiv
US5612319A (en) * 1994-05-31 1997-03-18 Medivir Ab Postexposure prevention of HIV infection or seroconversion
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
PL186888B1 (pl) * 1997-01-24 2004-03-31 Conpharma As Pochodne gemcytabiny
ES2325088T3 (es) 2004-12-30 2009-08-25 Medivir Ab Compuestos utiles en el tratamiento de hiv.
CN102952104A (zh) * 2011-08-17 2013-03-06 黑龙江省松花江药业有限公司 一种呋喃类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
US4908440A (en) * 1987-11-12 1990-03-13 Bristol Myers Company 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides
CA1312599C (en) * 1988-02-16 1993-01-12 Larry Wayne Hertel 2',3'dideoxy-2',2'difluoronucleosides
GB8920534D0 (en) * 1989-09-11 1989-10-25 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
KR900016249A (ko) 1990-11-13
FI95384C (fi) 1996-01-25
CA2013874A1 (en) 1990-10-06
AU633065B2 (en) 1993-01-21
EP0391411A2 (en) 1990-10-10
EP0391411A3 (en) 1991-04-10
AU5256090A (en) 1990-10-11
FI95384B (fi) 1995-10-13
PT93691B (pt) 1996-08-30
PT93691A (pt) 1990-11-20
KR930005991B1 (ko) 1993-07-01

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: BRISTOL-MYERS SQUIBB COMPANY