FI893361A - Menetelmä ACAT-inhiboivien kinoliinijohdannaisten valmistamiseksi - Google Patents

Menetelmä ACAT-inhiboivien kinoliinijohdannaisten valmistamiseksi Download PDF

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Publication number
FI893361A
FI893361A FI893361A FI893361A FI893361A FI 893361 A FI893361 A FI 893361A FI 893361 A FI893361 A FI 893361A FI 893361 A FI893361 A FI 893361A FI 893361 A FI893361 A FI 893361A
Authority
FI
Finland
Prior art keywords
preparation
quinoline derivatives
acat inhibiting
acat
inhibiting
Prior art date
Application number
FI893361A
Other languages
English (en)
Swedish (sv)
Other versions
FI93353B (fi
FI93353C (fi
FI893361A0 (fi
Inventor
Kanji Meguro
Hitoshi Ikeda
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FI893361A0 publication Critical patent/FI893361A0/fi
Publication of FI893361A publication Critical patent/FI893361A/fi
Publication of FI93353B publication Critical patent/FI93353B/fi
Application granted granted Critical
Publication of FI93353C publication Critical patent/FI93353C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
FI893361A 1988-07-12 1989-07-11 Menetelmä ACAT-inhiboivien kinoliinijohdannaisten valmistamiseksi FI93353C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP17413788 1988-07-12
JP17413788 1988-07-12
JP21426688 1988-08-29
JP21426688 1988-08-29
JP7592589 1989-03-27
JP7592589 1989-03-27

Publications (4)

Publication Number Publication Date
FI893361A0 FI893361A0 (fi) 1989-07-11
FI893361A true FI893361A (fi) 1990-01-13
FI93353B FI93353B (fi) 1994-12-15
FI93353C FI93353C (fi) 1995-03-27

Family

ID=27301993

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893361A FI93353C (fi) 1988-07-12 1989-07-11 Menetelmä ACAT-inhiboivien kinoliinijohdannaisten valmistamiseksi

Country Status (17)

Country Link
US (1) US5254565A (fi)
EP (1) EP0354994B1 (fi)
KR (1) KR900001656A (fi)
AT (1) ATE117681T1 (fi)
AU (1) AU616542B2 (fi)
CA (1) CA1333068C (fi)
DE (1) DE68920796T2 (fi)
DK (1) DK345989A (fi)
ES (1) ES2066808T3 (fi)
FI (1) FI93353C (fi)
GR (1) GR3015554T3 (fi)
HU (1) HU210861B (fi)
IE (1) IE892088L (fi)
IL (1) IL90815A (fi)
NO (1) NO177300C (fi)
NZ (1) NZ229911A (fi)
PT (1) PT91121B (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205037B (fi) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
JPH03181465A (ja) * 1989-12-11 1991-08-07 Takeda Chem Ind Ltd キノリン誘導体
DE4014171A1 (de) * 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
US5256782A (en) * 1990-08-17 1993-10-26 Takeda Chemical Industries, Ltd. Thienopyridine derivatives which are intermediates
US5143919A (en) * 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
JPH059179A (ja) * 1990-09-27 1993-01-19 Takeda Chem Ind Ltd 複素環化合物、その製造法及びａｃａｔ阻害剤
EP0590094A1 (en) * 1991-04-26 1994-04-06 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatives
IL101785A0 (en) * 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ATE175196T1 (de) * 1992-01-23 1999-01-15 Pfizer 4-phenyl-3-(heteroarylureido)-1,2-dihydro-2- oxochinolin derivate, als antihypercholesterolemische und antiatherosklerotische mittel
US5364875A (en) * 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5310748A (en) * 1992-05-11 1994-05-10 The Du Pont Merck Pharmaceutical Company Imidazoles for the treatment of atherosclerosis
US5462958A (en) * 1992-07-20 1995-10-31 Eisai Co., Ltd. Benzene derivatives and method of treating arteriosclerosis with benzene derivatives
DE69315920T2 (de) * 1992-09-04 1998-06-10 Takeda Chemical Industries Ltd Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung
US5565472A (en) * 1992-12-21 1996-10-15 Pfizer Inc. 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
GB9302275D0 (en) * 1993-02-05 1993-03-24 Smithkline Beecham Plc Novel compounds
NZ264063A (en) * 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5596001A (en) * 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
TW263498B (fi) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
US5491152A (en) * 1994-03-23 1996-02-13 The Du Pont Merck Pharmaceutical Company Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
JP3720395B2 (ja) * 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
CA2222687A1 (en) * 1995-05-31 1996-12-05 Masami Muraoka Novel naphthyridine derivatives
EP0866059B1 (en) 1995-10-05 2001-12-05 Kyoto Pharmaceutical Industries, Ltd. Novel heterocyclic derivatives and medicinal use thereof
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
DE19627430A1 (de) * 1996-07-08 1998-01-15 Bayer Ag Bicyclisch kondensierte Pyridine
DE60332851D1 (de) * 2002-07-17 2010-07-15 Kyoto Pharma Ind Indolinverbindung und deren medizinische verwendung
CA2603345C (en) 2005-04-01 2017-05-02 Insa Rouen New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
US20160332971A1 (en) * 2015-05-15 2016-11-17 University Of Kentucky Research Foundation Arylquinoline, arylquinolone and arylthioquinolone derivatives and use thereof to treat cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO133758C (fi) * 1970-04-04 1976-06-23 Takeda Chemical Industries Ltd
US3819634A (en) * 1970-07-23 1974-06-25 Takeda Chemical Industries Ltd 4-phenyl-3-thioacrylaminoquinolines
JPS555502B1 (fi) * 1971-07-31 1980-02-07

Also Published As

Publication number Publication date
DE68920796T2 (de) 1995-07-06
NZ229911A (en) 1991-08-27
AU3802589A (en) 1990-01-18
ATE117681T1 (de) 1995-02-15
EP0354994A3 (en) 1991-05-15
NO892851L (no) 1990-01-15
DE68920796D1 (de) 1995-03-09
GR3015554T3 (en) 1995-06-30
IE892088L (en) 1990-01-12
HU210861B (en) 1995-08-28
EP0354994B1 (en) 1995-01-25
AU616542B2 (en) 1991-10-31
DK345989A (da) 1990-01-13
FI93353B (fi) 1994-12-15
FI93353C (fi) 1995-03-27
ES2066808T3 (es) 1995-03-16
EP0354994A2 (en) 1990-02-21
NO177300C (no) 1995-08-23
PT91121B (pt) 1995-01-31
FI893361A0 (fi) 1989-07-11
HUT52059A (en) 1990-06-28
NO892851D0 (no) 1989-07-10
CA1333068C (en) 1994-11-15
KR900001656A (ko) 1990-02-27
IL90815A (en) 1993-07-08
IL90815A0 (en) 1990-01-18
NO177300B (no) 1995-05-15
DK345989D0 (da) 1989-07-12
US5254565A (en) 1993-10-19
PT91121A (pt) 1990-02-08

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: TAKEDA CHEMICAL INDUSTRIES, LTD.