FI892946A - Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi Download PDF

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Publication number
FI892946A
FI892946A FI892946A FI892946A FI892946A FI 892946 A FI892946 A FI 892946A FI 892946 A FI892946 A FI 892946A FI 892946 A FI892946 A FI 892946A FI 892946 A FI892946 A FI 892946A
Authority
FI
Finland
Prior art keywords
bridge
tetrahydro
preparation
therapeutically useful
benzazepine derivatives
Prior art date
Application number
FI892946A
Other languages
English (en)
Swedish (sv)
Other versions
FI93354C (fi
FI892946A0 (fi
FI93354B (fi
Inventor
Frederik Christian Groenwald
Peter Hoengaard Andersen
Peter Faarup
Erling Guddal
Kristian Tage Hansen
Erik Bardum Nielsen
Louis Brammer Hansen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of FI892946A0 publication Critical patent/FI892946A0/fi
Publication of FI892946A publication Critical patent/FI892946A/fi
Application granted granted Critical
Publication of FI93354B publication Critical patent/FI93354B/fi
Publication of FI93354C publication Critical patent/FI93354C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI892946A 1988-06-15 1989-06-15 Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi FI93354C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK325188A DK325188D0 (da) 1988-06-15 1988-06-15 Hidtil ukendte benzazepinderivater
DK325188 1988-06-15

Publications (4)

Publication Number Publication Date
FI892946A0 FI892946A0 (fi) 1989-06-15
FI892946A true FI892946A (fi) 1989-12-16
FI93354B FI93354B (fi) 1994-12-15
FI93354C FI93354C (fi) 1995-03-27

Family

ID=8120790

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892946A FI93354C (fi) 1988-06-15 1989-06-15 Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi

Country Status (15)

Country Link
US (2) US5010074A (fi)
EP (1) EP0347672B1 (fi)
JP (1) JP2769718B2 (fi)
AT (1) ATE102188T1 (fi)
AU (1) AU622911B2 (fi)
CA (1) CA1317938C (fi)
DE (1) DE68913367T2 (fi)
DK (1) DK325188D0 (fi)
ES (1) ES2061794T3 (fi)
FI (1) FI93354C (fi)
IE (1) IE891932L (fi)
IL (1) IL90533A (fi)
NO (1) NO173865C (fi)
NZ (1) NZ229521A (fi)
PT (1) PT90883B (fi)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
US5158948A (en) * 1990-11-16 1992-10-27 Abbott Laboratories Tetracyclic spirobenzazepine dopamine antagonists
US5470850A (en) * 1992-02-24 1995-11-28 Novo Nordisk A/S 2,3,4,5-tetrahydro-1H-3-benzazepines
DK23392D0 (da) * 1992-02-24 1992-02-24 Novo Nordisk As Heterocykliske forbindelser, deres anvendelse og fremstilling
CA2283083C (en) 1997-03-12 2007-09-04 Novo Nordisk A/S Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
US7211574B2 (en) * 2002-08-29 2007-05-01 Schering Corporation Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders
US7696193B2 (en) 2002-12-20 2010-04-13 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
CA2526017A1 (en) * 2003-05-22 2005-04-21 Schering Corporation 5-h-benzo[d]naphth[2,1-b]azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268243A (en) * 1968-03-11 1972-03-22 Wallace & Tiernan Inc 0,2,4,5,-tetrahydro-3h,3-benzazepines
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
ZA792042B (en) * 1978-05-08 1980-05-28 Scherico Ltd Substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4327023A (en) * 1980-01-31 1982-04-27 Smithkline Corporation Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
JPH0681745B2 (ja) * 1986-01-16 1994-10-19 シェリング・コ−ポレ−ション 縮合ベンゾアゼピン
EP0244088A3 (en) * 1986-04-03 1989-03-15 Smithkline Beecham Corporation 1-phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders

Also Published As

Publication number Publication date
IL90533A (en) 1994-05-30
ES2061794T3 (es) 1994-12-16
NO173865C (no) 1994-02-16
IE891932L (en) 1989-12-15
ATE102188T1 (de) 1994-03-15
FI93354C (fi) 1995-03-27
FI892946A0 (fi) 1989-06-15
NZ229521A (en) 1991-12-23
EP0347672A1 (en) 1989-12-27
JPH0240364A (ja) 1990-02-09
DE68913367T2 (de) 1994-06-01
FI93354B (fi) 1994-12-15
CA1317938C (en) 1993-05-18
NO892476D0 (no) 1989-06-14
PT90883B (pt) 1994-12-30
NO892476L (no) 1989-12-18
US5010074A (en) 1991-04-23
US5025009A (en) 1991-06-18
JP2769718B2 (ja) 1998-06-25
DE68913367D1 (de) 1994-04-07
NO173865B (no) 1993-11-08
IL90533A0 (en) 1990-01-18
AU3635989A (en) 1989-12-21
EP0347672B1 (en) 1994-03-02
AU622911B2 (en) 1992-04-30
PT90883A (pt) 1989-12-29
DK325188D0 (da) 1988-06-15

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FG Patent granted

Owner name: ADDEX PHARMACEUTICALS SA