FI892012A - Förfarande för framställning av nya terapeutiskt användbara 4-fenylpiperidinföreningar - Google Patents

Förfarande för framställning av nya terapeutiskt användbara 4-fenylpiperidinföreningar Download PDF

Info

Publication number
FI892012A
FI892012A FI892012A FI892012A FI892012A FI 892012 A FI892012 A FI 892012A FI 892012 A FI892012 A FI 892012A FI 892012 A FI892012 A FI 892012A FI 892012 A FI892012 A FI 892012A
Authority
FI
Finland
Prior art keywords
alkoxy
alkyl
cyano
aryl
halogen
Prior art date
Application number
FI892012A
Other languages
English (en)
Finnish (fi)
Other versions
FI92822B (sv
FI92822C (sv
FI892012A0 (sv
Inventor
Palle Jakobsen
Joergen Drejer
Original Assignee
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan As filed Critical Ferrosan As
Publication of FI892012A0 publication Critical patent/FI892012A0/sv
Publication of FI892012A publication Critical patent/FI892012A/sv
Publication of FI92822B publication Critical patent/FI92822B/sv
Application granted granted Critical
Publication of FI92822C publication Critical patent/FI92822C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
FI892012A 1988-04-28 1989-04-27 Förfarande för framställning av nya terapeutiskt användbara 4-fenylpiperidinföreningar FI92822C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK231088A DK231088D0 (da) 1988-04-28 1988-04-28 Piperidinforbindelser, deres fremstilling og anvendelse
DK231088 1988-04-28

Publications (4)

Publication Number Publication Date
FI892012A0 FI892012A0 (sv) 1989-04-27
FI892012A true FI892012A (sv) 1989-10-29
FI92822B FI92822B (sv) 1994-09-30
FI92822C FI92822C (sv) 1995-01-10

Family

ID=8111522

Family Applications (1)

Application Number Title Priority Date Filing Date
FI892012A FI92822C (sv) 1988-04-28 1989-04-27 Förfarande för framställning av nya terapeutiskt användbara 4-fenylpiperidinföreningar

Country Status (17)

Country Link
EP (1) EP0339579B1 (sv)
JP (1) JP2857414B2 (sv)
KR (1) KR900016175A (sv)
CN (1) CN1037332A (sv)
AT (1) ATE168375T1 (sv)
AU (1) AU631121B2 (sv)
DE (1) DE68928735T2 (sv)
DK (1) DK231088D0 (sv)
ES (1) ES2118708T3 (sv)
FI (1) FI92822C (sv)
HU (1) HUT55387A (sv)
IL (1) IL89903A0 (sv)
NO (1) NO173826C (sv)
NZ (1) NZ228895A (sv)
PT (1) PT90412B (sv)
ZA (1) ZA893003B (sv)
ZW (1) ZW4889A1 (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK640289D0 (da) * 1989-12-18 1989-12-18 Ferrosan As Ny heterocyklisk kemi
IL98757A (en) * 1990-07-18 1997-01-10 Novo Nordisk As Piperidine derivatives their preparation and pharmaceutical compositions containing them
GB9226111D0 (en) * 1992-12-15 1993-02-10 Smithkline Beecham Plc Madicaments
US5859001A (en) * 1996-01-11 1999-01-12 University Of Florida Research Foundation, Inc. Neuroprotective effects of polycyclic phenolic compounds
US6197833B1 (en) 1995-07-24 2001-03-06 Apollo Biopharmaceutics, Inc. Neuroprotective effects of polycyclic phenolic compounds
US6319914B1 (en) 1993-11-05 2001-11-20 Apollo Biopharmaceuticals, Inc. Cytoprotective effect of polycyclic phenolic compounds
ES2102295B1 (es) * 1994-03-18 1998-04-01 Ferrer Int Nuevos compuestos derivados de la n-benzoilmetil-piperidina.
US5723475A (en) * 1995-02-28 1998-03-03 Suntory Limited Arylpiperidine and arylpiperazine derivatives and medicament containing the same
JPH11510144A (ja) * 1995-07-24 1999-09-07 ユニバーシティー・オブ・フロリダ・リサーチ・ファンデーション・インコーポレーテッド 細胞に神経保護を付与するための薬剤の製造のための非エストロゲン多環式フェノール化合物の使用
ES2117557B1 (es) * 1996-02-29 1999-07-01 Ferrer Int Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.
WO1998003172A1 (fr) * 1996-07-22 1998-01-29 Suntory Limited Derives arylpiperidinol et arylpiperidine et medicaments les contenant
US6455549B1 (en) 1996-07-22 2002-09-24 Suntory Limited Arylpiperidinol and arylpiperidine derivatives and drugs containing the same
US6180648B1 (en) 1997-04-07 2001-01-30 Biostream Therapeutics, Inc. Analogs of cocaine
US6376672B1 (en) 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
WO2001032178A1 (en) * 1999-10-29 2001-05-10 Novo Nordisk A/S Use of 3,4-substituted piperidines
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
US20070142389A1 (en) * 2005-12-20 2007-06-21 Pfizer Inc. Piperidine derivatives
SI3344248T1 (sl) * 2015-09-02 2022-07-29 Trevena, Inc. 6-členske aza-heterociklične spojine za modulacijo, ki vsebujejo delta-opioidne receptorje, metode uporabe in izdelave
CA3052479A1 (en) 2017-02-17 2018-08-23 Trevena, Inc. 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
EP3582779B1 (en) 2017-02-17 2024-04-17 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0190496A3 (en) * 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
DE3688827T2 (de) * 1985-10-25 1994-03-31 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel.
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use

Also Published As

Publication number Publication date
IL89903A0 (en) 1989-12-15
DE68928735T2 (de) 1998-11-19
AU3336689A (en) 1989-11-02
NO891762D0 (no) 1989-04-27
AU631121B2 (en) 1992-11-19
EP0339579B1 (en) 1998-07-15
JP2857414B2 (ja) 1999-02-17
DK231088D0 (da) 1988-04-28
NO173826B (no) 1993-11-01
ZA893003B (en) 1989-12-27
ATE168375T1 (de) 1998-08-15
KR900016175A (ko) 1990-11-12
EP0339579A2 (en) 1989-11-02
JPH01313461A (ja) 1989-12-18
EP0339579A3 (en) 1991-12-18
NO891762L (no) 1989-10-30
NZ228895A (en) 1992-05-26
DE68928735D1 (de) 1998-08-20
HUT55387A (en) 1991-05-28
NO173826C (no) 1994-02-09
FI92822B (sv) 1994-09-30
CN1037332A (zh) 1989-11-22
FI92822C (sv) 1995-01-10
ZW4889A1 (en) 1989-08-09
PT90412B (pt) 1994-09-30
FI892012A0 (sv) 1989-04-27
PT90412A (pt) 1989-11-10
ES2118708T3 (es) 1998-10-01

Similar Documents

Publication Publication Date Title
FI892012A (sv) Förfarande för framställning av nya terapeutiskt användbara 4-fenylpiperidinföreningar
CA2106200A1 (en) Stereoselective preparation of substituted piperidines
DK314487A (da) Benzoxepinderivat
FI885592A (fi) Aryloxifenylpropylaminer, deras framstaellning och anvaendning.
ES2068216T3 (es) Compuestos de tienotriazolodiazepina y usos farmaceuticos de los mismos.
IT8619230A0 (it) Composti piperidinici atti all'impiego come stabilizzanti per polimeri sintetici.
IN164615B (sv)
DK0488345T3 (da) Optisk aktive 1,4-dihydropyridinderivater og fremgangsmåder til fremstilling deraf
IT8420449A0 (it) Composti piperidinici ad attivita'stabilizzante per polimeri sintetici.
DE69015324D1 (de) Herstellung von gegebenenfalls substituierten Chinolincopolymeren.
FR2640032B1 (fr) Methode de production d'oxygene ultra-pur
ATE76407T1 (de) T-butyl ergolinderivate.
DK187689A (da) Piperidine forbindelser, deres fremstilling og anvendelse
FR2633289B1 (fr) Procede de fabrication de l'acetate de vinyle
DE69004974D1 (de) Herstellung von 2-Chlorterephthalsäurechlorid.
ES2033859T3 (es) Acidos y esteres 2-amino-3-aroil-gamma-oxobencenbutanoicos.
DK560887A (da) Piperidin forbindelser, deres fremstilling og anvendelse
ATE27805T1 (de) Fluorierte verbindungen mit analgetischer und entzuendungshemmender wirkung.

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: NOVO NORDISK A/S