FI89172B - Nya oligosackarider och deras anvaendning foer framstaellning av immunogener - Google Patents

Nya oligosackarider och deras anvaendning foer framstaellning av immunogener Download PDF

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Publication number
FI89172B
FI89172B FI875727A FI875727A FI89172B FI 89172 B FI89172 B FI 89172B FI 875727 A FI875727 A FI 875727A FI 875727 A FI875727 A FI 875727A FI 89172 B FI89172 B FI 89172B
Authority
FI
Finland
Prior art keywords
compound
group
formula
oligosaccharide
groups
Prior art date
Application number
FI875727A
Other languages
English (en)
Finnish (fi)
Other versions
FI875727A (fi
FI875727A0 (fi
FI89172C (sv
Inventor
Boeckel Constant Adriaan A Van
Jan Theunis Poolman
Peter Hoogerhout
Eduard Coen Beuvery
Adolf Evenberg
Boom Jacobus Hubertus Van
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Publication of FI875727A0 publication Critical patent/FI875727A0/fi
Publication of FI875727A publication Critical patent/FI875727A/fi
Publication of FI89172B publication Critical patent/FI89172B/fi
Application granted granted Critical
Publication of FI89172C publication Critical patent/FI89172C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Claims (6)

1. Oligosackarid, kännetecknad därav, att den har följande formel 5 —: ovT r0/ wnA 'd V N -«f r > rM o W f-«r 0 W io H1 L JL It -1 m n q i vilken k = 0 eller 1, om 1=1, 15 k = 0, om 1 = 0, 1=0 eller 1, m = 2, 3 ... 19 eller 20, förutsatt att m kan vara 1, om k, 1 och n = 1 eller om 1, n och q = 1, n = 0 eller 1, 20 q = 0 eller 1, om n = 1, q = 0, om n = 0, X = väte, en reaktiv grupp som förmär, direkt eller indi-rekt, bilda en blndning med en bärare, eller en grupp som innehäller en hydrofob kedja i den obundna ändan, eller 25 ändgruppen X0- har ersatts av en reaktiv grupp H2N- eller HS-, och Y = väte, en reaktiv grupp som förmär, direkt eller indi-rekt, bilda en bindning med en bärare, eller en grupp som innehäller en hydrofob kedja i den obundna ändan, eller 30 ändgruppen -OY har ersatts av en reaktiv grupp -NH2 eller -SH, förutsatt att Y = väte, om X / väte och att X = väte, om Y i väte, och salter av denna.
2. Oligosackarid enligt patentkravet 1, k ä n n e-35 tecknad därav, att m = 2, 3, 4, 5 eller 6. 52 89172
3. Oligosackarid enligt patentkravet 1 eller 2, kännetecknad därav, att X = väte och Y φ väte.
4. Oligosackarid enligt patentkravet 1 eller 2, kännetecknad därav, att Y = väte och X Φ 5 väte.
5. Oligosackarid enligt nägot av patentkraven 1 -4, kännetecknad därav, att den reaktiva grup-pen är en grupp som innehäller nägon av följande reaktiva funktionella grupper 10 f -NH2, -SH, -S-S-Λ Λ , -N | , tai -C-R, N=/ 15 ° jossa R = OH, -N3, -0-alkyyli(C1_12), -OCgF^ 0 Λη -H, -Br, -Cl tai -0-N
20 V
6. Användning av en oligosackarid enligt patentkravet 1 för framställning av en immunogen. Il
FI875727A 1986-12-31 1987-12-28 Nya oligosackarider och deras användning för framställning av immunoge ner FI89172C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8603325 1986-12-31
NL8603325 1986-12-31

Publications (4)

Publication Number Publication Date
FI875727A0 FI875727A0 (fi) 1987-12-28
FI875727A FI875727A (fi) 1988-07-01
FI89172B true FI89172B (fi) 1993-05-14
FI89172C FI89172C (sv) 1993-08-25

Family

ID=19849078

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875727A FI89172C (sv) 1986-12-31 1987-12-28 Nya oligosackarider och deras användning för framställning av immunoge ner

Country Status (15)

Country Link
US (1) US5034519A (sv)
EP (1) EP0276516B1 (sv)
JP (1) JPS63190896A (sv)
KR (1) KR880007557A (sv)
AT (1) ATE87003T1 (sv)
AU (1) AU603405B2 (sv)
CA (1) CA1335405C (sv)
DE (1) DE3784907T2 (sv)
DK (1) DK694687A (sv)
ES (1) ES2054657T3 (sv)
FI (1) FI89172C (sv)
IE (1) IE59734B1 (sv)
NO (1) NO169775C (sv)
NZ (1) NZ223009A (sv)
PT (1) PT86484B (sv)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0320942A3 (en) * 1987-12-18 1989-10-04 American Cyanamid Company Novel polysaccharides novel macromolecular conjugates of the polysaccharides
ATE105189T1 (de) * 1988-04-19 1994-05-15 American Cyanamid Co Haemophilus influenzae typ b polysaccharidaussermembranprotein-konjugat als impfstoff.
US7118757B1 (en) * 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
CA2006587C (en) * 1988-12-23 2000-01-18 Robert W. Tolan Membrane proteins and peptides of haemophilus influenzae type b
GB8924473D0 (en) * 1989-10-31 1989-12-20 Connaught Lab Outer membrane protein p1 and peptides of haemophilus influenzae b
NZ239643A (en) * 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
US5153312A (en) * 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
ATE176989T1 (de) * 1990-12-21 1999-03-15 Antex Biolog Inc Adhesin-oligosaccharid-impfstoffkonjugate für - i(haemophilus influenza)
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
EP0514588B1 (en) * 1991-05-20 1997-06-11 Kao Corporation Novel phosphobetaine and detergent and cosmetic containing the same
US5371197A (en) * 1991-09-24 1994-12-06 Merck & Co., Inc. Protein-dimeric polysaccharide conjugate vaccine
GB9202219D0 (en) * 1992-02-03 1992-03-18 Connaught Lab A synthetic heamophilus influenzae conjugate vaccine
ATE380871T1 (de) * 1992-06-25 2007-12-15 Univ Georgetown Papillomavirus vakzine
US7148031B2 (en) 1994-07-26 2006-12-12 The Mitre Corporation Sequestering of glycoprotein molecules and oligosaccharide moieties in lipo-glycoprotein membranes and micelles
US5782396A (en) 1995-08-28 1998-07-21 United States Surgical Corporation Surgical stapler
US5762256A (en) 1995-08-28 1998-06-09 United States Surgical Corporation Surgical stapler
US6032849A (en) * 1995-08-28 2000-03-07 United States Surgical Surgical stapler
SE9601158D0 (sv) * 1996-03-26 1996-03-26 Stefan Svenson Method of producing immunogenic products and vaccines
JP4162267B2 (ja) * 1996-08-27 2008-10-08 カイロン コーポレイション Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ血清型Ｂ複合糖質およびその使用法
US6267961B1 (en) * 1996-11-22 2001-07-31 Baxter International Inc. Direct methods for molar-mass determination of fragments of Haemophilus influenzae type b capsular polysaccharides and vaccine preparation
CU22904A1 (es) * 1999-08-30 2004-01-23 Univ De Ottawa Oligosacáridos derivados de ribosa- ribitol-fosfato, métodos para prepararlos, inmunógenos que los comprenden y vacunas que comprenden dichos inmunógenos
US8785134B2 (en) 2008-11-10 2014-07-22 The Mitre Corporation Glycoprotein vesicles and their methods of use
US11014952B2 (en) 2016-07-28 2021-05-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against Haemophilus influenzae type b
CN108776223B (zh) * 2018-04-19 2021-04-06 广州质量监督检测研究院 紫外吸收剂uv-326检测试剂盒及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220717A (en) * 1977-12-22 1980-09-02 American Cyanamid Company Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
US4264764A (en) * 1979-01-12 1981-04-28 Merck & Co., Inc. Meningitis vaccine
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4451446A (en) * 1982-03-04 1984-05-29 Smithkline-Rit Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
US4459286A (en) * 1983-01-31 1984-07-10 Merck & Co., Inc. Coupled H. influenzae type B vaccine

Also Published As

Publication number Publication date
FI875727A (fi) 1988-07-01
IE59734B1 (en) 1994-03-23
EP0276516B1 (en) 1993-03-17
KR880007557A (ko) 1988-08-27
IE873510L (en) 1988-06-30
NO169775C (no) 1992-08-05
NO875442D0 (no) 1987-12-28
PT86484A (en) 1988-01-01
AU8314587A (en) 1988-07-07
ES2054657T3 (es) 1994-08-16
NZ223009A (en) 1990-06-26
DE3784907T2 (de) 1993-06-24
EP0276516A3 (en) 1988-08-17
NO875442L (no) 1988-07-01
DE3784907D1 (de) 1993-04-22
FI875727A0 (fi) 1987-12-28
DK694687A (da) 1988-07-01
JPS63190896A (ja) 1988-08-08
NO169775B (no) 1992-04-27
AU603405B2 (en) 1990-11-15
ATE87003T1 (de) 1993-04-15
CA1335405C (en) 1995-04-25
EP0276516A2 (en) 1988-08-03
PT86484B (pt) 1990-11-20
DK694687D0 (da) 1987-12-30
FI89172C (sv) 1993-08-25
US5034519A (en) 1991-07-23

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