ATE176989T1 - Adhesin-oligosaccharid-impfstoffkonjugate für - i(haemophilus influenza) - Google Patents

Adhesin-oligosaccharid-impfstoffkonjugate für - i(haemophilus influenza)

Info

Publication number
ATE176989T1
ATE176989T1 AT92902826T AT92902826T ATE176989T1 AT E176989 T1 ATE176989 T1 AT E176989T1 AT 92902826 T AT92902826 T AT 92902826T AT 92902826 T AT92902826 T AT 92902826T AT E176989 T1 ATE176989 T1 AT E176989T1
Authority
AT
Austria
Prior art keywords
influenzae
adhesin
prp
proteins
conjugates
Prior art date
Application number
AT92902826T
Other languages
English (en)
Inventor
Howard C Krivan
James E Samuel
Nils Thomas Norberg
Original Assignee
Antex Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antex Biolog Inc filed Critical Antex Biolog Inc
Application granted granted Critical
Publication of ATE176989T1 publication Critical patent/ATE176989T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT92902826T 1990-12-21 1991-12-20 Adhesin-oligosaccharid-impfstoffkonjugate für - i(haemophilus influenza) ATE176989T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63169890A 1990-12-21 1990-12-21

Publications (1)

Publication Number Publication Date
ATE176989T1 true ATE176989T1 (de) 1999-03-15

Family

ID=24532360

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92902826T ATE176989T1 (de) 1990-12-21 1991-12-20 Adhesin-oligosaccharid-impfstoffkonjugate für - i(haemophilus influenza)

Country Status (8)

Country Link
EP (1) EP0565590B1 (de)
JP (1) JP3330935B2 (de)
AT (1) ATE176989T1 (de)
CA (1) CA2098598A1 (de)
DE (1) DE69130955T2 (de)
DK (1) DK0565590T3 (de)
ES (1) ES2131066T3 (de)
WO (1) WO1992010936A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2805174B2 (ja) * 1992-06-22 1998-09-30 アンテックス バイオロジックス，インコーポレーテッド ヘモフィルス・インフルエンザ用アドヘシン−オリゴ糖複合体ワクチン
US5506139A (en) * 1994-07-21 1996-04-09 Connaught Laboratories Limited Analog of haemophilus Hin47 with reduced protease activity
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity
US5981503A (en) * 1994-06-07 1999-11-09 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
US6147057A (en) * 1994-07-21 2000-11-14 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
NZ291750A (en) * 1994-07-21 1997-10-24 Connaught Lab Analogues of haemophilus influenzae hin47 protein with reduced protease activity
US5681570A (en) 1995-01-12 1997-10-28 Connaught Laboratories Limited Immunogenic conjugate molecules
US5646259A (en) 1995-03-24 1997-07-08 St. Louis University DNA encoding haemophilus adhesion proteins
US5780606A (en) * 1995-06-07 1998-07-14 Connaught Laboratories Limited Neisseria meningitidis capsular polysaccharide conjugates
US9134303B1 (en) 1998-08-25 2015-09-15 Alere Scarborough, Inc. ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto
US6824997B1 (en) 1998-09-18 2004-11-30 Binax, Inc. Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
JP4856836B2 (ja) * 2000-03-01 2012-01-18 バイナックス インコーポレイティッド 標的細菌またはその標的糖質抗原成分の存在を検出する方法
US11014952B2 (en) 2016-07-28 2021-05-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Stable hydrolysis-resistant synthetic polyribosylribitolphosphate derivatives as vaccines against Haemophilus influenzae type b

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
US5173294A (en) * 1986-11-18 1992-12-22 Research Foundation Of State University Of New York Dna probe for the identification of haemophilus influenzae
NZ223009A (en) * 1986-12-31 1990-06-26 Nl Rivm Of Thoven Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens
EP0320942A3 (de) * 1987-12-18 1989-10-04 American Cyanamid Company Polysaccharide und makromolekulare Verbindungen davon
DE68915046T2 (de) * 1988-04-19 1994-12-08 American Cyanamid Co Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
EP0378929A3 (de) * 1988-12-23 1990-08-01 Connaught Laboratories Limited Membran-Proteine und Peptide von Haemophilus influenzae Typ B
GB8924473D0 (en) * 1989-10-31 1989-12-20 Connaught Lab Outer membrane protein p1 and peptides of haemophilus influenzae b

Also Published As

Publication number Publication date
DE69130955T2 (de) 1999-07-01
EP0565590A1 (de) 1993-10-20
WO1992010936A1 (en) 1992-07-09
CA2098598A1 (en) 1992-06-22
EP0565590A4 (de) 1995-07-05
DE69130955D1 (de) 1999-04-08
JP3330935B2 (ja) 2002-10-07
DK0565590T3 (da) 1999-09-27
EP0565590B1 (de) 1999-03-03
JPH06508346A (ja) 1994-09-22
ES2131066T3 (es) 1999-07-16

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Legal Events

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