FI89056B - Nya 11-arylsteroidfoereningar - Google Patents
Nya 11-arylsteroidfoereningar Download PDFInfo
- Publication number
- FI89056B FI89056B FI885717A FI885717A FI89056B FI 89056 B FI89056 B FI 89056B FI 885717 A FI885717 A FI 885717A FI 885717 A FI885717 A FI 885717A FI 89056 B FI89056 B FI 89056B
- Authority
- FI
- Finland
- Prior art keywords
- group
- hydroxyl
- carbon atoms
- compounds
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Gyroscopes (AREA)
- Fats And Perfumes (AREA)
Claims (7)
1 I \l6 4 5 6 7 R4 varl Rj är en fenylgrupp, vilken innefattar gruppen -N-X 15 Y som substituent; X och Y betecknar bäda skilt för sig väte eller en kolvätegrupp eller tillsammans en C2_6-kolvätegrupp som med kväveatomen bildar en ring med 3-7 led;
20 R2 är en mättad eller omättad kolvätegrupp med 1-8 kol-atomer, väri minst en hydroxylgrupp är ansluten till kol-vätegruppen; R3 är hydroxyl; eller R2 och R3 tillsammans bildar ett 5- eller 6-ledat 25 ringsystem med en syreatom; och R4 är en metyl- eller etylgrupp; och a- och β-bindningar är betecknade med streckad linje (---) respektive kilformiga ( ) streck.
2. Föreningar enligt patentkravet 1, k ä n n e -30 tecknade därav, att Rx är en aminofenylgrupp med strukturen 35 ΧΥ väri x och Y betecknar skilt för sig en mättad alkylgrupp med 1-3 kolatomer. 21 89056
3. Föreningar enligt patentkravet 1 eller 2, kännetecknade därav, att R2 är en mättad eller omättad alkylgrupp som innehäller 1-4 kolatomer och som är substituerad med ätminstone en hydroxylgrupp. 5
4. Förening enligt patentkravet 1 eller 2, k ä n - netecknad därav, att R2 och R3 bildar ett 5- eller 6-ledat ringsystem.
5. Föreningar enligt nägot av patentkraven 1-4, kännetecknade därav, att R4 är en metylgrupp. 10
6. Förfarande för framställning av föreningar en ligt patentkravet 1, kännetecknat därav, att en förening med formeln r5o^K^/>r4 OR, OH 20 6 väri Rj, R2, R3 och R4 betecknar Samina som ovan, förutsatt att grupper som betecknar grupperna R2 och R3 och innehäller syre kan även beteckna en syre innehällande grupp, väri syreatomen är skyddad med en hydrolyserbar grupp, och 25 väri R5 och R6 betecknar en alkylgrupp som innehäller 1 -4 kolatomer, eller R5 och R6 tillsammans betecknar en alky-lengrupp som innehäller 2-5 kolatomer, hydrolyseras och dehydreras för bildande av önskad förening och att de erhällna föreningarnas i 17p-position 30 belägna hydroxylgrupp förestras om sä önskas eller att de erhällna föreningarnas i 17p-position belägna hydroxylgrupp cykleras om sä önskas med en i 17a-position belägen grupp som innehäller syre.
7. Preventivmedelsprodukt, känneteck-35 n a d därav, att den aktiva beständsdelen bestär av en — eller flera föreningar enligt patentkravet 1 blandade i en fysiologiskt acceptabel bärare.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8703008 | 1987-12-12 | ||
| NL8703008 | 1987-12-12 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI885717A0 FI885717A0 (fi) | 1988-12-09 |
| FI885717A FI885717A (fi) | 1989-06-13 |
| FI89056B true FI89056B (fi) | 1993-04-30 |
| FI89056C FI89056C (sv) | 1993-08-10 |
Family
ID=19851082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI885717A FI89056C (sv) | 1987-12-12 | 1988-12-09 | Nya 11-arylsteroidföreningar |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4921845A (sv) |
| EP (1) | EP0321010B1 (sv) |
| JP (1) | JP2768707B2 (sv) |
| KR (1) | KR970009592B1 (sv) |
| CN (1) | CN1019807B (sv) |
| AT (1) | ATE85342T1 (sv) |
| AU (1) | AU613433B2 (sv) |
| CA (1) | CA1301162C (sv) |
| DE (1) | DE3878198T2 (sv) |
| DK (1) | DK168444B1 (sv) |
| ES (1) | ES2053714T3 (sv) |
| FI (1) | FI89056C (sv) |
| IE (1) | IE61848B1 (sv) |
| NZ (1) | NZ227269A (sv) |
| PT (1) | PT89185B (sv) |
| ZA (1) | ZA888996B (sv) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0411733B1 (de) * | 1989-08-04 | 1998-10-21 | Schering Aktiengesellschaft | 11 Beta-Aryl-gona-4,9-dien-3-one |
| FR2650748B1 (fr) * | 1989-08-08 | 1991-11-08 | Roussel Uclaf | Nouveaux esters d'acides organiques avec des alcools derives de 19-nor steroides et leurs sels, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions les renfermant |
| DE4018168A1 (de) * | 1990-06-01 | 1991-12-05 | Schering Ag | Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen |
| US5407928A (en) * | 1990-08-15 | 1995-04-18 | Schering Aktiengesellschaft | 11β-aryl-gona-4,9-dien-3-ones |
| ZA929315B (en) * | 1991-12-20 | 1993-05-24 | Akzo Nv | 17-spirofuran-3'-ylidene steroids. |
| CA2100514C (en) * | 1992-07-29 | 2005-03-29 | Johannes A. M. Hamersma | 17-spiromethylene steroids |
| EP0683172B1 (en) * | 1994-05-19 | 1997-08-13 | Akzo Nobel N.V. | 11,21-Bisphenyl-19-norpregnane derivatives |
| DE4434488A1 (de) * | 1994-09-14 | 1996-03-21 | Schering Ag | Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| IL115659A (en) * | 1994-10-27 | 2000-06-01 | Akzo Nobel Nv | Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them |
| ZA9510926B (en) | 1994-12-23 | 1996-07-03 | Schering Ag | Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception |
| US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
| DK0900234T3 (da) * | 1996-05-01 | 2000-11-06 | Us Gov Health & Human Serv | 21-substituerede progesteronderivater anvendt som nye antigestagener |
| US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| US5962444A (en) * | 1998-05-29 | 1999-10-05 | Research Triangle Institute | 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| US6262042B1 (en) * | 1998-05-29 | 2001-07-17 | Research Triangle Institute | 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
| FR2789393B1 (fr) * | 1999-02-05 | 2001-10-12 | Centre Nat Rech Scient | Lactol steroidique |
| JP4845320B2 (ja) * | 2000-03-31 | 2011-12-28 | アメリカ合衆国 | （７α，１１β）−ジメチル−１７β−ヒドロキシ−４−エストレン−３−オンの４−Ｎ−ブチルシクロヘキサン酸エステル及びウンデカン酸エステルの製造方法及びそれらの医学用途 |
| AU2004217988C1 (en) * | 2003-02-28 | 2010-06-03 | Southwest Foundation For Biomedical Research | Method for preparing 17 alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates |
| SI3263112T1 (sl) | 2006-10-24 | 2020-10-30 | Allergan Pharmaceuticals International Limited | Sestavki in metode za zaviranje endometrijskih proliferacij |
| TWI539953B (zh) | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
| KR102166867B1 (ko) | 2010-03-22 | 2020-10-19 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | 항프로게스틴의 비독성 전달을 위한 조성물들과 그 방법들 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA8231B (en) * | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| US4780461A (en) * | 1983-06-15 | 1988-10-25 | Schering Aktiengesellschaft | 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same |
| DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
| AU580843B2 (en) * | 1985-02-07 | 1989-02-02 | Schering Aktiengesellschaft | 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them |
| GB8513723D0 (en) * | 1985-05-31 | 1985-07-03 | Erba Farmitalia | 11-beta substituted steroids |
-
1988
- 1988-11-25 DE DE8888202678T patent/DE3878198T2/de not_active Expired - Fee Related
- 1988-11-25 ES ES88202678T patent/ES2053714T3/es not_active Expired - Lifetime
- 1988-11-25 EP EP88202678A patent/EP0321010B1/en not_active Expired - Lifetime
- 1988-11-25 AT AT88202678T patent/ATE85342T1/de not_active IP Right Cessation
- 1988-11-29 IE IE356588A patent/IE61848B1/en not_active IP Right Cessation
- 1988-11-30 ZA ZA888996A patent/ZA888996B/xx unknown
- 1988-12-01 AU AU26469/88A patent/AU613433B2/en not_active Ceased
- 1988-12-07 PT PT89185A patent/PT89185B/pt not_active IP Right Cessation
- 1988-12-08 CA CA000585297A patent/CA1301162C/en not_active Expired - Fee Related
- 1988-12-08 US US07/281,582 patent/US4921845A/en not_active Expired - Fee Related
- 1988-12-09 NZ NZ227269A patent/NZ227269A/xx unknown
- 1988-12-09 DK DK688088A patent/DK168444B1/da not_active IP Right Cessation
- 1988-12-09 FI FI885717A patent/FI89056C/sv not_active IP Right Cessation
- 1988-12-10 KR KR88016480A patent/KR970009592B1/ko not_active IP Right Cessation
- 1988-12-12 CN CN88108484A patent/CN1019807B/zh not_active Expired
- 1988-12-12 JP JP63313643A patent/JP2768707B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT89185A (pt) | 1989-12-29 |
| IE61848B1 (en) | 1994-11-30 |
| NZ227269A (en) | 1990-06-26 |
| ZA888996B (en) | 1989-08-30 |
| DK688088A (da) | 1989-06-13 |
| CA1301162C (en) | 1992-05-19 |
| KR890009968A (ko) | 1989-08-05 |
| ES2053714T3 (es) | 1994-08-01 |
| ATE85342T1 (de) | 1993-02-15 |
| AU2646988A (en) | 1989-06-15 |
| EP0321010B1 (en) | 1993-02-03 |
| JPH01211597A (ja) | 1989-08-24 |
| IE883565L (en) | 1989-06-12 |
| DE3878198T2 (de) | 1993-06-24 |
| DE3878198D1 (de) | 1993-03-18 |
| FI885717A (fi) | 1989-06-13 |
| KR970009592B1 (en) | 1997-06-14 |
| EP0321010A1 (en) | 1989-06-21 |
| FI885717A0 (fi) | 1988-12-09 |
| DK168444B1 (da) | 1994-03-28 |
| US4921845A (en) | 1990-05-01 |
| JP2768707B2 (ja) | 1998-06-25 |
| FI89056C (sv) | 1993-08-10 |
| CN1019807B (zh) | 1992-12-30 |
| AU613433B2 (en) | 1991-08-01 |
| DK688088D0 (da) | 1988-12-09 |
| CN1034731A (zh) | 1989-08-16 |
| PT89185B (pt) | 1993-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: AKZO N.V. |