FI885670A - 3-hydroxi-2- (4-metoxifenyl) -5- (2-metylaminoetyl) -2,3-dihydro-5h-1,5-benzotiazepin-4-on derivat, deras framstaellning och terapeutiska anvaendning. - Google Patents

3-hydroxi-2- (4-metoxifenyl) -5- (2-metylaminoetyl) -2,3-dihydro-5h-1,5-benzotiazepin-4-on derivat, deras framstaellning och terapeutiska anvaendning. Download PDF

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Publication number
FI885670A
FI885670A FI885670A FI885670A FI885670A FI 885670 A FI885670 A FI 885670A FI 885670 A FI885670 A FI 885670A FI 885670 A FI885670 A FI 885670A FI 885670 A FI885670 A FI 885670A
Authority
FI
Finland
Prior art keywords
benzotiazepin
methoxifenyl
anvaendning
methylaminoethyl
dihydro
Prior art date
Application number
FI885670A
Other languages
English (en)
Other versions
FI885670A0 (fi
Inventor
Alistair Lochead
Jean-Claude Muller
Christian Hoornaert
Colombe Denys
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of FI885670A0 publication Critical patent/FI885670A0/fi
Publication of FI885670A publication Critical patent/FI885670A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
FI885670A 1987-12-08 1988-12-07 3-hydroxi-2- (4-metoxifenyl) -5- (2-metylaminoetyl) -2,3-dihydro-5h-1,5-benzotiazepin-4-on derivat, deras framstaellning och terapeutiska anvaendning. FI885670A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8717044A FR2624117B1 (fr) 1987-12-08 1987-12-08 Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FI885670A0 FI885670A0 (fi) 1988-12-07
FI885670A true FI885670A (fi) 1989-06-09

Family

ID=9357609

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885670A FI885670A (fi) 1987-12-08 1988-12-07 3-hydroxi-2- (4-metoxifenyl) -5- (2-metylaminoetyl) -2,3-dihydro-5h-1,5-benzotiazepin-4-on derivat, deras framstaellning och terapeutiska anvaendning.

Country Status (13)

Country Link
EP (2) EP0320362A1 (fi)
JP (2) JPH01190674A (fi)
KR (1) KR890009901A (fi)
AU (1) AU609681B2 (fi)
DK (1) DK681088A (fi)
FI (1) FI885670A (fi)
FR (1) FR2624117B1 (fi)
HU (1) HU201538B (fi)
IL (1) IL88608A0 (fi)
NO (1) NO167802C (fi)
NZ (1) NZ227235A (fi)
PT (1) PT89182A (fi)
ZA (1) ZA889169B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2630109B1 (fr) * 1988-04-19 1991-11-29 Synthelabo Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
US4963545A (en) * 1988-05-24 1990-10-16 Marion Laboratories, Inc. Benzothiazepine anti-seizure method
US5134139A (en) * 1989-08-31 1992-07-28 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and preparation thereof
FR2653122B1 (fr) * 1989-10-17 1994-04-15 Synthelabo Derives de 5-[2-[[2-amino-2-oxoethyl]methylamino]ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepine-4-one, leur preparation et leur application en therapeutique.
CA2030160A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Benzothiazepine metastasis treatment
CA2030159A1 (en) * 1989-11-22 1991-05-23 Nahed K. Ahmed Anti-cancer drug potentiators
FR2670785B1 (fr) * 1990-12-20 1993-07-09 Synthelabo Derives de (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique.
EP0702009B1 (en) * 1994-09-16 1998-07-01 Orion Corporation Fermion Method for the preparation of pharmaceutically active benzothiazepine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4585768A (en) * 1984-04-10 1986-04-29 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and processes for preparing the same
US4594342A (en) * 1984-04-10 1986-06-10 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivative
ES2038668T3 (es) * 1986-08-20 1993-08-01 Mcneilab, Inc. Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica.
US4729994A (en) * 1986-08-20 1988-03-08 Mcneilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
FR2630109B1 (fr) * 1988-04-19 1991-11-29 Synthelabo Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2624117A1 (fr) 1989-06-09
KR890009901A (ko) 1989-08-04
EP0320361A1 (fr) 1989-06-14
JPH01190674A (ja) 1989-07-31
FI885670A0 (fi) 1988-12-07
PT89182A (pt) 1989-12-29
NO167802C (no) 1991-12-11
AU609681B2 (en) 1991-05-02
IL88608A0 (en) 1989-07-31
HU201538B (en) 1990-11-28
NO885435L (no) 1989-06-09
ZA889169B (en) 1990-05-30
NO885435D0 (no) 1988-12-07
FR2624117B1 (fr) 1991-02-22
AU2659588A (en) 1989-06-08
DK681088A (da) 1989-06-09
NZ227235A (en) 1990-06-26
DK681088D0 (da) 1988-12-07
JPH01190632A (ja) 1989-07-31
EP0320362A1 (fr) 1989-06-14
HUT50797A (en) 1990-03-28
NO167802B (no) 1991-09-02

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Owner name: SYNTHELABO